Identification
HMDB Protein ID CDBP01379
Secondary Accession Numbers Not Available
Name V-type proton ATPase subunit e 1
Description Not Available
Synonyms
  1. V-ATPase 9.2 kDa membrane accessory protein
  2. V-ATPase M9.2 subunit
  3. V-ATPase subunit e 1
  4. Vacuolar proton pump subunit e 1
Gene Name ATP6V0E1
Protein Type Enzyme
Biological Properties
General Function Involved in hydrogen ion transmembrane transporter activity
Specific Function Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells
GO Classification
Component
macromolecular complex
protein complex
proton-transporting two-sector atpase complex, proton-transporting domain
proton-transporting v-type atpase, v0 domain
Function
hydrogen ion transmembrane transporter activity
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
Process
establishment of localization
transport
purine nucleotide metabolic process
energy coupled proton transport, against electrochemical gradient
purine nucleotide biosynthetic process
atp hydrolysis coupled proton transport
purine nucleoside triphosphate biosynthetic process
atp biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
atp synthesis coupled proton transport
hydrogen transport
proton transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:5
Locus 5q35.1
SNPs ATP6V0E1
Gene Sequence
>246 bp
ATGGCGTATCACGGCCTCACTGTGCCTCTCATTGTGATGAGCGTGTTCTGGGGCTTCGTC
GGCTTCTTGGTGCCTTGGTTCATCCCTAAGGGTCCTAACCGGGGAGTTATCATTACCATG
TTGGTGACCTGTTCAGTTTGCTGCTATCTCTTTTGGCTGATTGCAATTCTGGCCCAACTC
AACCCTCTCTTTGGACCGCAATTGAAAAATGAAACCATCTGGTATCTGAAGTATCATTGG
CCTTGA
Protein Properties
Number of Residues 81
Molecular Weight 9374.3
Theoretical pI 8.87
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["8-28", "36-56"]
Protein Sequence
>V-type proton ATPase subunit e 1
MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQL
NPLFGPQLKNETIWYLKYHWP
GenBank ID Protein 2584789
UniProtKB/Swiss-Prot ID O15342
UniProtKB/Swiss-Prot Entry Name VA0E1_HUMAN
PDB IDs Not Available
GenBank Gene ID Y15286
GeneCard ID ATP6V0E1
GenAtlas ID ATP6V0E1
HGNC ID HGNC:863
References
General References Not Available