Identification
HMDB Protein ID CDBP01347
Secondary Accession Numbers Not Available
Name Probable phospholipid-transporting ATPase IIB
Description Not Available
Synonyms
  1. ATPase class II type 9B
Gene Name ATP9B
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
GO Classification
Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
atp binding
magnesium ion binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion binding
substrate-specific transporter activity
cation binding
lipid transporter activity
metal ion binding
phospholipid transporter activity
binding
phospholipid-translocating atpase activity
catalytic activity
atpase activity, coupled to transmembrane movement of ions
hydrolase activity
atpase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
nucleoside binding
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
purine nucleoside binding
hydrolase activity, acting on acid anhydrides
adenyl nucleotide binding
adenyl ribonucleotide binding
Process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
establishment of localization
transport
lipid transport
phospholipid transport
atp biosynthetic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 18q23
SNPs ATP9B
Gene Sequence
>3444 bp
ATGGCGGACCAGATCCCGCTTTACCCGGTGCGTAGCGCAGCGGCGGCCGCAGCCAACCGC
AAACGCGCGGCCTACTACAGCGCCGCGGGGCCCAGGCCGGGAGCCGACCGGCACAGCAGG
TACCAGCTGGAGGATGAGTCTGCGCATTTGGATGAAATGCCACTAATGATGTCTGAAGAA
GGCTTTGAGAATGAGGAAAGTGATTACCACACCTTACCACGAGCCAGGATAATGCAAAGG
AAAAGAGGACTGGAGTGGTTTGTCTGTGATGGCTGGAAGTTCCTCTGTACCAGTTGCTGT
GGTTGGCTGATAAATATTTGTCGAAGAAAGAAAGAGCTGAAAGCTCGCACAGTATGGCTT
GGATGTCCTGAAAAGTGTGAAGAAAAACATCCCAGGAATTCTATAAAAAATCAAAAATAC
AATGTGTTTACCTTTATACCTGGGGTTTTGTATGAACAATTCAAGTTTTTCTTGAATCTC
TATTTTCTAGTAATATCCTGCTCACAGTTTGTACCAGCATTGAAAATAGGCTATCTCTAC
ACCTACTGGGCTCCTCTGGGATTTGTCTTGGCTGTTACTATGACACGGGAAGCAATTGAT
GAATTTCGGCGTTTTCAGCGTGACAAGGAAGTGAATTCACAACTATATAGCAAGCTTACA
GTAAGAGGTAAAGTGCAAGTTAAGAGTTCAGACATACAAGTTGGAGACCTCATCATAGTG
GAAAAGAATCAAAGAATTCCATCGGACATGGTGTTTCTTAGGACTTCAGAAAAAGCAGGT
TCGTGTTTTATTCGAACTGATCAACTAGATGGTGAAACTGACTGGAAGCTGAAGGTGGCA
GTGAGCTGCACGCAACAGCTGCCGGCTCTGGGGGACCTTTTTTCTATCAGTGCTTATGTT
TATGCTCAGAAACCACAAATGGACATTCACAGTTTCGAAGGCACATTTACCAGGGAAGAC
AGTGACCCGCCCATTCATGAAAGTCTCAGCATAGAAAATACATTGTGGGCAAGCACCATT
GTTGCATCAGGTACTGTAATAGGTGTTGTCATTTATACCGGAAAAGAGACTCGAAGTGTA
ATGAACACATCCAATCCAAAAAATAAGGTTGGTTTGTTGGACCTTGAACTCAATCGGCTG
ACGAAAGCGCTATTTTTGGCTTTAGTTGCTCTTTCCATTGTTATGGTAACCTTACAAGGA
TTTGTGGGTCCATGGTACCGCAATCTTTTTCGGTTCCTTCTCCTCTTTTCTTACATCATT
CCCATAAGTTTGCGTGTGAACTTGGACATGGGCAAAGCGGTGTATGGATGGATGATGATG
AAAGATGAGAACATCCCTGGCACGGTCGTTCGGACCAGCACTATCCCAGAGGAACTTGGG
CGCCTGGTGTATTTATTGACAGACAAAACAGGAACCCTCACCCAGAATGAAATGATATTT
AAGCGGCTGCACCTGGGCACCGTGTCCTATGGCGCCGACACGATGGATGAGATCCAGAGC
CATGTCAGGGACTCCTACTCACAGATGCAGTCTCAAGCTGGTGGAAACAATACTGGTTCA
ACTCCACTAAGAAAAGCCCAATCTTCAGCTCCCAAAGTTAGGAAAAGTGTCAGTAGTCGA
ATCCATGAAGCCGTGAAAGCCATCGTGCTGTGTCACAACGTGACCCCCGTGTATGAGTCT
CGGGCCGGCGTTACTGAGGAGACTGAGTTCGCAGAGGCTGACCAAGACTTCAGTGATGAG
AATCGCACCTACCAGGCTTCCAGCCCGGATGAGGTCGCTCTGGTGCAGTGGACAGAGAGT
GTGGGCCTCACGCTGGTCAGCAGGGACCTCACCTCCATGCAGCTGAAGACCCCCAGTGGC
CAGGTCCTCAGCTTCTGCATTCTGCAGCTGTTTCCCTTCACCTCCGAGAGCAAGCGGATG
GGCGTCATCGTCAGGGATGAATCCACGGCAGAAATCACATTCTACATGAAGGGCGCTGAC
GTGGCCATGTCTCCTATCGTGCAGTATAATGACTGGCTGGAAGAGGAGTGCGGAAACATG
GCTCGCGAAGGACTGCGGACCCTCGTGGTTGCAAAGAAGGCGTTGACAGAGGAGCAGTAC
CAGGACTTTGAGAGCCGATACACTCAAGCCAAGCTGAGCATGCACGACAGGTCCCTCAAG
GTGGCCGCGGTAGTCGAGAGCCTGGAGAGGGAGATGGAACTGCTGTGCCTCACCGGCGTG
GAGGACCAGCTGCAGGCAGACGTGCGGCCCACGCTGGAGATGCTGCGCAACGCCGGGATC
AAGATATGGATGCTAACAGGCGATAAACTCGAGACAGCTACCTGCATTGCCAAAAGTTCA
CATCTCGTGTCTAGAACACAAGATATTCATATTTTCAGACAGGTAACCAGTCGGGGAGAG
GCACATTTGGAGCTGAATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCATATCTGGG
GACTCTCTGGAGGTTTGTCTAAAGTACTACGAGCATGAATTTGTGGAGCTGGCCTGCCAG
TGCCCTGCCGTGGTTTGCTGCCGCTGCTCACCCACCCAGAAGGCCCGCATTGTGACACTG
CTGCAGCAGCACACAGGGAGACGCACCTGCGCCATCGGTGATGGAGGAAATGATGTCAGC
ATGATTCAGGCAGCAGACTGTGGGATTGGGATTGAGGGAAAGGAGGGTAAACAGGCCTCG
CTGGCGGCCGACTTCTCCATCACGCAGTTCCGGCACATAGGCAGGCTGCTCATGGTGCAC
GGGCGGAACAGCTACAAGAGGTCGGCGGCACTCGGCCAGTTCGTCATGCACAGGGGCCTT
ATCATCTCCACCATGCAGGCTGTGTTTTCCTCAGTCTTCTACTTCGCATCCGTCCCTTTG
TATCAGGGCTTCCTCATGGTGGGGTATGCCACCATATACACCATGTTCCCAGTGTTCTCC
TTAGTGCTGGACCAGGACGTGAAGCCAGAGATGGCGATGCTCTACCCGGAGCTGTACAAG
GACCTCACCAAGGGAAGATCCTTGTCCTTCAAAACCTTCCTCATCTGGGTTTTAATAAGT
ATTTACCAAGGCGGCATCCTCATGTATGGGGCCCTGGTGCTCTTCGAGTCTGAGTTCGTC
CACGTGGTGGCCATCTCCTTCACCGCACTGATCCTGACCGAGCTGCTGATGGTGGCGCTG
ACCGTCCGCACGTGGCACTGGCTGATGGTGGTGGCCGAGTTCCTCAGCTTAGGCTGCTAC
GTGTCCTCACTCGCTTTTCTCAATGAATATTTTGGTATAGGCAGAGTGTCTTTTGGAGCT
TTCTTAGATGTTGCCTTTATCACCACCGTGACCTTCCTGTGGAAAGTGTCGGCGATCACC
GTGGTCAGCTGCCTCCCGCTGTATGTCCTCAAGTACCTGAGGCGCAAGCTCTCTCCTCCC
AGCTACTGCAAGCTGGCCTCCTAA
Protein Properties
Number of Residues 1147
Molecular Weight 129302.4
Theoretical pI 7.64
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["147-168", "174-196", "381-401", "410-431", "931-951", "964-982", "1013-1031", "1039-1061", "1068-1088", "1106-1130"]
Protein Sequence
>Probable phospholipid-transporting ATPase IIB
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEE
GFENEESDYHTLPRARIMQRKRGLEWFVCDGWKFLCTSCCGWLINICRRKKELKARTVWL
GCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIV
EKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQQLPALGDLFSISAYV
YAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYII
PISLRVNLDMGKAVYGWMMMKDENIPGTVVRTSTIPEELGRLVYLLTDKTGTLTQNEMIF
KRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSR
IHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTES
VGLTLVSRDLTSMQLKTPSGQVLSFCILQLFPFTSESKRMGVIVRDESTAEITFYMKGAD
VAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLK
VAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSS
HLVSRTQDIHIFRQVTSRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEHEFVELACQ
CPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQAS
LAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPL
YQGFLMVGYATIYTMFPVFSLVLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVLIS
IYQGGILMYGALVLFESEFVHVVAISFTALILTELLMVALTVRTWHWLMVVAEFLSLGCY
VSSLAFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKYLRRKLSPP
SYCKLAS
GenBank ID Protein 41327760
UniProtKB/Swiss-Prot ID O43861
UniProtKB/Swiss-Prot Entry Name ATP9B_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_198531.3
GeneCard ID ATP9B
GenAtlas ID ATP9B
HGNC ID HGNC:13541
References
General References Not Available