Identification |
HMDB Protein ID
| CDBP01304 |
Secondary Accession Numbers
| Not Available |
Name
| V-type proton ATPase subunit B, brain isoform |
Description
| Not Available |
Synonyms
|
- Endomembrane proton pump 58 kDa subunit
- HO57
- V-ATPase subunit B 2
- Vacuolar proton pump subunit B 2
|
Gene Name
| ATP6V1B2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in ATP binding |
Specific Function
| Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells |
GO Classification
|
Component |
proton-transporting two-sector atpase complex |
proton-transporting two-sector atpase complex, catalytic domain |
proton-transporting v-type atpase, v1 domain |
macromolecular complex |
protein complex |
Function |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
cation transmembrane transporter activity |
inorganic cation transmembrane transporter activity |
monovalent inorganic cation transmembrane transporter activity |
binding |
hydrogen ion transmembrane transporter activity |
catalytic activity |
transporter activity |
hydrolase activity |
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances |
nucleoside binding |
hydrolase activity, acting on acid anhydrides |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
proton-transporting atpase activity, rotational mechanism |
hydrogen ion transporting atp synthase activity, rotational mechanism |
Process |
cellular nitrogen compound metabolic process |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
nucleobase, nucleoside and nucleotide metabolic process |
nucleoside phosphate metabolic process |
nucleotide metabolic process |
atp synthesis coupled proton transport |
purine nucleoside triphosphate metabolic process |
purine ribonucleoside triphosphate metabolic process |
atp metabolic process |
hydrogen transport |
proton transport |
purine nucleotide metabolic process |
establishment of localization |
purine nucleotide biosynthetic process |
transport |
purine nucleoside triphosphate biosynthetic process |
atp biosynthetic process |
purine ribonucleoside triphosphate biosynthetic process |
metabolic process |
nitrogen compound metabolic process |
|
Cellular Location
|
- Endomembrane system
- Melanosome
- Peripheral membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:8 |
Locus
| 8p21.3 |
SNPs
| ATP6V1B2 |
Gene Sequence
|
>1536 bp
ATGGCGCTGCGGGCGATGCGGGGGATTGTCAACGGGGCCGCACCCGAGCTACCCGTGCCC
ACCGGTGGGCCGGCGGTGGGAGCTCGGGAGCAGGCGCTGGCAGTCAGTCGGAACTACCTC
TCCCAGCCTCGCCTCACATACAAGACAGTATCTGGAGTCAATGGTCCACTAGTGATCTTA
GATCATGTTAAGTTTCCCAGGTATGCTGAAATTGTCCATTTGACCTTACCGGATGGCACA
AAGAGAAGTGGGCAAGTTCTGGAAGTTAGTGGTTCCAAGGCAGTAGTTCAGGTATTTGAA
GGGACTTCAGGTATAGATGCTAAGAAAACGTCCTGTGAGTTTACTGGGGATATTCTCCGA
ACACCGGTGTCTGAGGATATGCTTGGTCGGGTATTCAATGGATCGGGAAAACCCATTGAC
AGAGGTCCTGTTGTACTGGCCGAAGACTTCCTTGATATCATGGGTCAGCCAATCAACCCT
CAATGTCGAATCTACCCAGAGGAAATGATTCAGACTGGCATTTCGGCCATCGATGGGATG
AACAGTATTGCTAGGGGGCAGAAAATTCCTATCTTCTCTGCTGCTGGGCTACCACACAAT
GAGATTGCAGCTCAGATCTGTCGCCAGGCTGGTTTGGTAAAGAAATCCAAAGATGTAGTA
GACTACAGTGAGGAAAATTTTGCAATTGTATTTGCTGCTATGGGTGTAAACATGGAAACT
GCCCGGTTCTTCAAATCTGACTTTGAAGAAAATGGCTCAATGGACAATGTCTGCCTCTTT
TTGAACTTGGCTAATGACCCAACCATTGAGCGAATTATCACTCCTCGCCTGGCTCTAACC
ACAGCTGAATTTCTGGCGTACCAATGTGAGAAACATGTATTGGTTATTCTAACAGACATG
AGTTCTTATGCTGAAGCACTTCGAGAGGTTTCAGCAGCCAGGGAAGAGGTACCTGGTCGA
CGAGGTTTTCCAGGTTACATGTATACAGATTTAGCCACGATATATGAACGCGCTGGGCGA
GTGGAAGGGAGAAACGGCTCGATTACTCAAATCCCTATTCTAACCATGCCTAATGATGAT
ATCACTCACCCCATCCCAGACTTGACTGGCTACATTACAGAGGGGCAGATCTATGTGGAC
AGACAGCTGCACAACAGACAGATTTATCCACCTATCAATGTGCTGCCCTCACTATCACGG
TTAATGAAGTCTGCTATTGGAGAAGGGATGACCAGGAAGGATCATGCCGATGTATCTAAC
CAGCTATATGCGTGCTATGCTATTGGAAAGGATGTGCAAGCCATGAAAGCTGTCGTTGGA
GAAGAAGCCCTTACCTCAGATGATCTTCTCTACTTGGAATTTCTGCAGAAGTTTGAGAGG
AACTTCATTGCTCAGGGTCCTTACGAAAATCGCACTGTCTTTGAGACTTTGGACATTGGC
TGGCAGCTACTCCGAATCTTCCCCAAAGAAATGCTGAAGAGAATCCCTCAGAGCACCCTC
AGCGAATTTTACCCTCGAGACTCTGCAAAGCATTAG
|
Protein Properties |
Number of Residues
| 511 |
Molecular Weight
| 56500.2 |
Theoretical pI
| 5.55 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>V-type proton ATPase subunit B, brain isoform
MALRAMRGIVNGAAPELPVPTGGPAVGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVIL
DHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILR
TPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGM
NSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMET
ARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDM
SSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDD
ITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSN
QLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIG
WQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
|
External Links |
GenBank ID Protein
| 189065451 |
UniProtKB/Swiss-Prot ID
| P21281 |
UniProtKB/Swiss-Prot Entry Name
| VATB2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK312372 |
GeneCard ID
| ATP6V1B2 |
GenAtlas ID
| ATP6V1B2 |
HGNC ID
| HGNC:854 |
References |
General References
| Not Available |