Cannabis Compound Database: Showing Protein Ephrin type-A receptor 3 (CDBP01275)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP01275

Secondary Accession Numbers

Not Available

Name

Ephrin type-A receptor 3

Description

Not Available

Synonyms

EK4
EPH-like kinase 4
HEK
Tyrosine-protein kinase TYRO4
Tyrosine-protein kinase receptor ETK1
hEK4

Gene Name

EPHA3

Protein Type

Enzyme

Biological Properties

General Function

Involved in ephrin receptor activity

Specific Function

Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function

GO Classification

Component
integral to plasma membrane
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
ephrin receptor activity
protein binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
Process
phosphorylation
phosphorus metabolic process
phosphate metabolic process
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
metabolic process
cellular metabolic process
protein amino acid phosphorylation
signaling
signaling pathway
cell surface receptor linked signaling pathway

Cellular Location

Isoform 2:Secreted

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:3

Locus

3p11.2

SNPs

EPHA3

Gene Sequence

>2952 bp
ATGGATTGTCAGCTCTCCATCCTCCTCCTTCTCAGCTGCTCTGTTCTCGACAGCTTCGGG
GAACTGATTCCGCAGCCTTCCAATGAAGTCAATCTACTGGATTCAAAAACAATTCAAGGG
GAGCTGGGCTGGATCTCTTATCCATCACATGGGTGGGAAGAGATCAGTGGTGTGGATGAA
CATTACACACCCATCAGGACTTACCAGGTGTGCAATGTCATGGACCACAGTCAAAACAAT
TGGCTGAGAACAAACTGGGTCCCCAGGAACTCAGCTCAGAAGATTTATGTGGAGCTCAAG
TTCACTCTACGAGACTGCAATAGCATTCCATTGGTTTTAGGAACTTGCAAGGAGACATTC
AACCTGTACTACATGGAGTCTGATGATGATCATGGGGTGAAATTTCGAGAGCATCAGTTT
ACAAAGATTGACACCATTGCAGCTGATGAAAGTTTCACTCAAATGGATCTTGGGGACCGT
ATTCTGAAGCTCAACACTGAGATTAGAGAAGTAGGTCCTGTCAACAAGAAGGGATTTTAT
TTGGCATTTCAAGATGTTGGTGCTTGTGTTGCCTTGGTGTCTGTGAGAGTATACTTCAAA
AAGTGCCCATTTACAGTGAAGAATCTGGCTATGTTTCCAGACACGGTACCCATGGACTCC
CAGTCCCTGGTGGAGGTTAGAGGGTCTTGTGTCAACAATTCTAAGGAGGAAGATCCTCCA
AGGATGTACTGCAGTACAGAAGGCGAATGGCTTGTACCCATTGGCAAGTGTTCCTGCAAT
GCTGGCTATGAAGAAAGAGGTTTTATGTGCCAAGCTTGTCGACCAGGTTTCTACAAGGCA
TTGGATGGTAATATGAAGTGTGCTAAGTGCCCGCCTCACAGTTCTACTCAGGAAGATGGT
TCAATGAACTGCAGGTGTGAGAATAATTACTTCCGGGCAGACAAAGACCCTCCATCCATG
GCTTGTACCCGACCTCCATCTTCACCAAGAAATGTTATCTCTAATATAAACGAGACCTCA
GTTATCCTGGACTGGAGTTGGCCCCTGGACACAGGAGGCCGGAAAGATGTTACCTTCAAC
ATCATATGTAAAAAATGTGGGTGGAATATAAAACAGTGTGAGCCATGCAGCCCAAATGTC
CGCTTCCTCCCTCGACAGTTTGGACTCACCAACACCACGGTGACAGTGACAGACCTTCTG
GCACATACTAACTACACCTTTGAGATTGATGCCGTTAATGGGGTGTCAGAGCTGAGCTCC
CCACCAAGACAGTTTGCTGCGGTCAGCATCACAACTAATCAGGCTGCTCCATCACCTGTC
CTGACGATTAAGAAAGATCGGACCTCCAGAAATAGCATCTCTTTGTCCTGGCAAGAACCT
GAACATCCTAATGGGATCATATTGGACTACGAGGTCAAATACTATGAAAAGCAGGAACAA
GAAACAAGTTATACCATTCTGAGGGCAAGAGGCACAAATGTTACCATCAGTAGCCTCAAG
CCTGACACTATATACGTATTCCAAATCCGAGCCCGAACAGCCGCTGGATATGGGACGAAC
AGCCGCAAGTTTGAGTTTGAAACTAGTCCAGACTCTTTCTCCATCTCTGGTGAAAGTAGC
CAAGTGGTCATGATCGCCATTTCAGCGGCAGTAGCAATTATTCTCCTCACTGTTGTCATC
TATGTTTTGATTGGGAGGTTCTGTGGCTATAAGTCAAAACATGGGGCAGATGAAAAAAGA
CTTCATTTTGGCAATGGGCATTTAAAACTTCCAGGTCTCAGGACTTATGTTGACCCACAT
ACATATGAAGACCCTACCCAAGCTGTTCATGAGTTTGCCAAGGAATTGGATGCCACCAAC
ATATCCATTGATAAAGTTGTTGGAGCAGGTGAATTTGGAGAGGTGTGCAGTGGTCGCTTA
AAACTTCCTTCAAAAAAAGAGATTTCAGTGGCCATTAAGACCCTGAAAGTTGGCTACACA
GAAAAGCAGAGGAGAGACTTCCTGGGAGAAGCAAGCATTATGGGACAGTTTGACCACCCC
AATATCATTCGACTGGAAGGAGTTGTTACCAAAAGTAAGCCAGTTATGATTGTCACAGAA
TACATGGAGAATGGTTCCTTGGATAGTTTCCTACGTAAACACGATGCCCAGTTTACTGTC
ATTCAGCTAGTGGGGATGCTTCGAGGGATAGCATCTGGCATGAAGTACCTGTCAGACATG
GGCTATGTTCACCGAGACCTCGCTGCTCGGAACATCTTGATCAACAGTAACTTGGTGTGT
AAGGTTTCTGATTTCGGACTTTCGCGTGTCCTGGAGGATGACCCAGAAGCTGCTTATACA
ACAAGAGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAAGCTATAGCCTACCGCAAG
TTCACGTCAGCCAGCGATGTATGGAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTAT
GGAGAGAGACCATACTGGGAGATGTCCAATCAGGATGTAATTAAAGCTGTAGATGAGGGC
TATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTATCAGCTGATGCTGGACTGC
TGGCAGAAAGACAGGAACAACAGACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAG
CTTATCCGGAATCCCGGCAGCCTGAAGATCATCACCAGTGCAGCCGCAAGGCCATCAAAC
CTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGCACAACAGGTGACTGGCTT
AATGGTGTCTGGACAGCACACTGCAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGT
GACACAATAGCCAAGATTTCCACAGATGACATGAAAAAGGTTGGTGTCACCGTGGTTGGG
CCACAGAAGAAGATCATCAGTAGCATTAAAGCTCTAGAAACGCAATCAAAGAATGGCCCA
GTTCCCGTGTAA

Protein Properties

Number of Residues

983

Molecular Weight

110129.7

Theoretical pI

6.73

Pfam Domain Function

SAM_2 (PF07647 )
Pkinase_Tyr (PF07714 )
Ephrin_lbd (PF01404 )
fn3 (PF00041 )
GCC2_GCC3 (PF07699 )

Signals

["1-20"]

Transmembrane Regions

["542-565"]

Protein Sequence

>Ephrin type-A receptor 3
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDE
HYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETF
NLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFY
LAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPP
RMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDG
SMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFN
IICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSS
PPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQ
ETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESS
QVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPH
TYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYT
EKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTV
IQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT
TRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG
YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSN
LLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVG
PQKKIISSIKALETQSKNGPVPV

External Links

GenBank ID Protein

12003435

UniProtKB/Swiss-Prot ID

P29320

UniProtKB/Swiss-Prot Entry Name

EPHA3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF213459

GeneCard ID