Identification
HMDB Protein ID CDBP01260
Secondary Accession Numbers Not Available
Name V-type proton ATPase subunit d 1
Description Not Available
Synonyms
  1. 32 kDa accessory protein
  2. V-ATPase 40 kDa accessory protein
  3. V-ATPase AC39 subunit
  4. V-ATPase subunit d 1
  5. Vacuolar proton pump subunit d 1
  6. p39
Gene Name ATP6V0D1
Protein Type Enzyme
Biological Properties
General Function Involved in hydrogen ion transmembrane transporter activity
Specific Function Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis
GO Classification
Component
macromolecular complex
protein complex
proton-transporting two-sector atpase complex, proton-transporting domain
proton-transporting v-type atpase, v0 domain
Function
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
transmembrane transporter activity
Process
nucleoside phosphate metabolic process
nucleotide metabolic process
atp synthesis coupled proton transport
atp biosynthetic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16q22.1
SNPs ATP6V0D1
Gene Sequence
>1056 bp
ATGTCGTTCTTCCCGGAGCTTTACTTTAACGTGGACAATGGCTACTTGGAGGGACTGGTG
CGCGGCCTGAAGGCCGGGGTGCTCAGCCAGGCCGACTACCTCAACCTGGTGCAGTGCGAG
ACGCTAGAGGACTTGAAACTGCATCTGCAGAGCACTGATTATGGTAACTTCCTGGCCAAC
GAGGCATCACCTCTGACGGTGTCAGTCATCGATGACCGGCTCAAGGAGAAGATGGTGGTG
GAGTTCCGCCACATGAGGAACCATGCCTATGAGCCACTCGCCAGCTTCCTAGACTTCATT
ACTTACAGTTACATGATCGACAACGTGATCCTGCTCATCACAGGCACGCTGCACCAGCGC
TCCATCGCTGAGCTCGTGCCCAAGTGCCACCCACTAGGCAGCTTCGAGCAGATGGAGGCC
GTGAACATTGCTCAGACACCTGCTGAGCTCTACAATGCCATTCTGGTGGACACGCCTCTT
GCGGCTTTTTTCCAGGACTGCATTTCAGAGCAGGACCTTGACGAGATGAACATCGAGATC
ATCCGCAACACCCTCTACAAGGCCTACCTGGAGTCCTTCTACAAGTTCTGCACCCTACTG
GGCGGGACTACGGCTGATGCCATGTGCCCCATCCTGGAGTTTGAAGCAGACCGCCGCGCC
TTCATCATCACCATCAATTCTTTCGGCACAGAGCTGTCCAAAGAGGACCGTGCCAAGCTC
TTTCCACACTGTGGGCGGCTCTACCCTGAGGGCCTGGCGCAGCTGGCTCGGGCTGACGAC
TATGAACAGGTCAAGAACGTGGCCGATTACTACCCGGAGTACAAGCTGCTCTTCGAGGGT
GCAGGTAGCAACCCTGGAGACAAGACGCTGGAGGACCGATTCTTTGAGCACGAGGTAAAG
CTGAACAAGTTGGCCTTCCTGAACCAGTTCCACTTTGGTGTCTTCTATGCCTTCGTGAAG
CTCAAGGAGCAGGAGTGTCGCAACATCGTGTGGATCGCTGAATGTATCGCCCAGCGCCAC
CGCGCCAAAATCGACAACTACATCCCTATCTTCTAG
Protein Properties
Number of Residues 351
Molecular Weight 40328.7
Theoretical pI 4.63
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>V-type proton ATPase subunit d 1
MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLAN
EASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQR
SIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEI
IRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKL
FPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVK
LNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
GenBank ID Protein 14250784
UniProtKB/Swiss-Prot ID P61421
UniProtKB/Swiss-Prot Entry Name VA0D1_HUMAN
PDB IDs Not Available
GenBank Gene ID BC008861
GeneCard ID ATP6V0D1
GenAtlas ID ATP6V0D1
HGNC ID HGNC:13724
References
General References Not Available