| Identification |
|---|
| HMDB Protein ID
| CDBP01253 |
| Secondary Accession Numbers
| Not Available |
| Name
| TP53-regulating kinase |
| Description
| Not Available |
| Synonyms
|
- Nori-2
- p53-related protein kinase
|
| Gene Name
| TP53RK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| phosphotransferase activity, alcohol group as acceptor |
| protein kinase activity |
| protein tyrosine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| primary metabolic process |
| lipopolysaccharide biosynthetic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| lipid metabolic process |
| phosphorylation |
| lipid biosynthetic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20q13.2 |
| SNPs
| TP53RK |
| Gene Sequence
|
>762 bp
ATGGCGGCGGCCAGAGCTACTACGCCGGCCGATGGCGAGGAGCCCGCCCCGGAGGCTGAG
GCTCTGGCCGCAGCCCGGGAACGGAGCAGCCGCTTCTTGAGCGGCCTGGAGCTGGTGAAG
CAGGGTGCCGAGGCGCGCGTGTTCCGTGGCCGCTTCCAGGGCCGCGCGGCGGTGATCAAG
CACCGCTTCCCCAAGGGCTACCGGCACCCGGCGCTGGAGGCGCGGCTTGGCAGACGGCGG
ACGGTGCAGGAGGCCCGGGCGCTCCTCCGCTGTCGCCGCGCTGGAATATCTGCCCCAGTT
GTCTTTTTTGTGGACTATGCTTCCAACTGCTTATATATGGAAGAAATTGAAGGCTCAGTG
ACTGTTCGAGATTATATTCAGTCCACTATGGAGACTGAAAAAACTCCCCAGGGTCTCTCC
AACTTAGCCAAGACAATTGGGCAGGTTTTGGCTCGAATGCACGATGAAGACCTCATTCAT
GGTGATCTCACCACCTCCAACATGCTCCTGAAACCCCCCCTGGAACAGCTGAACATTGTG
CTCATAGACTTTGGGCTGAGTTTCATTTCAGCACTTCCAGAGGATAAGGGAGTAGACCTC
TATGTCCTGGAGAAGGCCTTCCTCAGTACCCATCCCAACACTGAAACTGTGTTTGAAGCC
TTTCTGAAGAGCTACTCCACCTCCTCCAAAAAGGCCAGGCCAGTGCTAAAAAAATTAGAT
GAAGTGCGCCTGAGAGGAAGAAAGAGGTCCATGGTTGGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 253 |
| Molecular Weight
| 28160.1 |
| Theoretical pI
| 10.06 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>TP53-regulating kinase
MAAARATTPADGEEPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIK
HRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSV
TVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIV
LIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLD
EVRLRGRKRSMVG
|
| External Links |
|---|
| GenBank ID Protein
| 14715460 |
| UniProtKB/Swiss-Prot ID
| Q96S44 |
| UniProtKB/Swiss-Prot Entry Name
| PRPK_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB017505 |
| GeneCard ID
| TP53RK |
| GenAtlas ID
| TP53RK |
| HGNC ID
| HGNC:16197 |
| References |
|---|
| General References
| Not Available |