Identification
HMDB Protein ID CDBP01253
Secondary Accession Numbers Not Available
Name TP53-regulating kinase
Description Not Available
Synonyms
  1. Nori-2
  2. p53-related protein kinase
Gene Name TP53RK
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation
GO Classification
Component
membrane
cell part
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
phosphotransferase activity, alcohol group as acceptor
protein kinase activity
protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
primary metabolic process
lipopolysaccharide biosynthetic process
cellular metabolic process
protein amino acid phosphorylation
lipid metabolic process
phosphorylation
lipid biosynthetic process
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 20q13.2
SNPs TP53RK
Gene Sequence
>762 bp
ATGGCGGCGGCCAGAGCTACTACGCCGGCCGATGGCGAGGAGCCCGCCCCGGAGGCTGAG
GCTCTGGCCGCAGCCCGGGAACGGAGCAGCCGCTTCTTGAGCGGCCTGGAGCTGGTGAAG
CAGGGTGCCGAGGCGCGCGTGTTCCGTGGCCGCTTCCAGGGCCGCGCGGCGGTGATCAAG
CACCGCTTCCCCAAGGGCTACCGGCACCCGGCGCTGGAGGCGCGGCTTGGCAGACGGCGG
ACGGTGCAGGAGGCCCGGGCGCTCCTCCGCTGTCGCCGCGCTGGAATATCTGCCCCAGTT
GTCTTTTTTGTGGACTATGCTTCCAACTGCTTATATATGGAAGAAATTGAAGGCTCAGTG
ACTGTTCGAGATTATATTCAGTCCACTATGGAGACTGAAAAAACTCCCCAGGGTCTCTCC
AACTTAGCCAAGACAATTGGGCAGGTTTTGGCTCGAATGCACGATGAAGACCTCATTCAT
GGTGATCTCACCACCTCCAACATGCTCCTGAAACCCCCCCTGGAACAGCTGAACATTGTG
CTCATAGACTTTGGGCTGAGTTTCATTTCAGCACTTCCAGAGGATAAGGGAGTAGACCTC
TATGTCCTGGAGAAGGCCTTCCTCAGTACCCATCCCAACACTGAAACTGTGTTTGAAGCC
TTTCTGAAGAGCTACTCCACCTCCTCCAAAAAGGCCAGGCCAGTGCTAAAAAAATTAGAT
GAAGTGCGCCTGAGAGGAAGAAAGAGGTCCATGGTTGGGTAG
Protein Properties
Number of Residues 253
Molecular Weight 28160.1
Theoretical pI 10.06
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>TP53-regulating kinase
MAAARATTPADGEEPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIK
HRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSV
TVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIV
LIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLD
EVRLRGRKRSMVG
GenBank ID Protein 14715460
UniProtKB/Swiss-Prot ID Q96S44
UniProtKB/Swiss-Prot Entry Name PRPK_HUMAN
PDB IDs Not Available
GenBank Gene ID AB017505
GeneCard ID TP53RK
GenAtlas ID TP53RK
HGNC ID HGNC:16197
References
General References Not Available