Identification |
HMDB Protein ID
| CDBP01230 |
Secondary Accession Numbers
| Not Available |
Name
| ATP synthase protein 8 |
Description
| Not Available |
Synonyms
|
- A6L
- F-ATPase subunit 8
|
Gene Name
| MT-ATP8 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in hydrogen ion transmembrane transporter activity |
Specific Function
| Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane |
GO Classification
|
Component |
cell part |
membrane part |
mitochondrial proton-transporting atp synthase complex, coupling factor f(o) |
mitochondrial membrane part |
Function |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
cation transmembrane transporter activity |
inorganic cation transmembrane transporter activity |
monovalent inorganic cation transmembrane transporter activity |
hydrogen ion transmembrane transporter activity |
transporter activity |
Process |
purine nucleoside triphosphate biosynthetic process |
purine ribonucleoside triphosphate biosynthetic process |
metabolic process |
nitrogen compound metabolic process |
cellular nitrogen compound metabolic process |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
nucleobase, nucleoside and nucleotide metabolic process |
nucleoside phosphate metabolic process |
nucleotide metabolic process |
atp synthesis coupled proton transport |
atp biosynthetic process |
purine nucleotide metabolic process |
purine nucleotide biosynthetic process |
|
Cellular Location
|
- Mitochondrion membrane
- Single-pass membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| MT-ATP8 |
Gene Sequence
|
>207 bp
ATGCCCCAACTAAATACTACCGTATGGCCCACCATAATTACCCCCATACTCCTTACACTA
TTCCTCATCACCCAACTAAAAATATTAAACACAAACTACCACCTACCTCCCTCACCAAAG
CCCATAAAAATAAAAAATTATAACAAACCCTGAGAACCAAAATGAACGAAAATCTGTTCG
CTTCATTCATTGCCCCCACAATCCTAG
|
Protein Properties |
Number of Residues
| 68 |
Molecular Weight
| 7991.6 |
Theoretical pI
| 10.56 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>ATP synthase protein 8
MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKMKNYNKPWEPKWTKICS
LHSLPPQS
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P03928 |
UniProtKB/Swiss-Prot Entry Name
| ATP8_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| J01415 |
GeneCard ID
| MT-ATP8 |
GenAtlas ID
| MT-ATP8 |
HGNC ID
| HGNC:7415 |
References |
General References
| Not Available |