Identification
HMDB Protein ID CDBP01230
Secondary Accession Numbers Not Available
Name ATP synthase protein 8
Description Not Available
Synonyms
  1. A6L
  2. F-ATPase subunit 8
Gene Name MT-ATP8
Protein Type Enzyme
Biological Properties
General Function Involved in hydrogen ion transmembrane transporter activity
Specific Function Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane
GO Classification
Component
cell part
membrane part
mitochondrial proton-transporting atp synthase complex, coupling factor f(o)
mitochondrial membrane part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
Process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
atp synthesis coupled proton transport
atp biosynthetic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
Cellular Location
  1. Mitochondrion membrane
  2. Single-pass membrane protein
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs MT-ATP8
Gene Sequence
>207 bp
ATGCCCCAACTAAATACTACCGTATGGCCCACCATAATTACCCCCATACTCCTTACACTA
TTCCTCATCACCCAACTAAAAATATTAAACACAAACTACCACCTACCTCCCTCACCAAAG
CCCATAAAAATAAAAAATTATAACAAACCCTGAGAACCAAAATGAACGAAAATCTGTTCG
CTTCATTCATTGCCCCCACAATCCTAG
Protein Properties
Number of Residues 68
Molecular Weight 7991.6
Theoretical pI 10.56
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["8-24"]
Protein Sequence
>ATP synthase protein 8
MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKMKNYNKPWEPKWTKICS
LHSLPPQS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P03928
UniProtKB/Swiss-Prot Entry Name ATP8_HUMAN
PDB IDs Not Available
GenBank Gene ID J01415
GeneCard ID MT-ATP8
GenAtlas ID MT-ATP8
HGNC ID HGNC:7415
References
General References Not Available