Cannabis Compound Database: Showing Protein Non-receptor tyrosine-protein kinase TNK1 (CDBP01211)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP01211

Secondary Accession Numbers

Not Available

Name

Non-receptor tyrosine-protein kinase TNK1

Description

Not Available

Synonyms

CD38 negative kinase 1

Gene Name

TNK1

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein kinase activity

Specific Function

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction

GO Classification

Component
cell part
intracellular part
cytoplasm
Function
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
Process
regulation of cellular process
signal transduction
protein amino acid phosphorylation
phosphorylation
phosphorus metabolic process
phosphate metabolic process
regulation of growth
regulation of cell growth
metabolic process
protein amino acid autophosphorylation
biological regulation
regulation of biological process
cellular metabolic process
negative regulation of cell growth

Cellular Location

Cytoplasm
Peripheral membrane protein
Membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17p13.1

SNPs

TNK1

Gene Sequence

>2001 bp
ATGCTTCCCGAGGCTGGCTCCCTGTGGCTACTGAAGCTGCTCCGGGACATCCAGTTGGCC
CAGTTTTACTGGCCCATCCTAGAGGAGCTTAATGTCACCCGGCCAGGGCACTTCGACTTT
GTAAAGCCTGAGGACCTGGACGGCATTGGCATGGGCCGGCCTGCCCAACGCAGACTGTCC
GAAGCTCTGAAAAGCCTACGTTCTGGGCCTAAGTCTAAGAACTGGGTCTACAAGATCCTT
GGAGGTTTTGCCCCTGAGCACAAGGAGCCCACCCTGCCCACGGACAGCCCACGGCACCTC
CCTGAGCCAGAGGGGGGCCTCAAGTGTCTGATCCCAGAGGGTGCTGTTTGCAGAGGGGAG
CTGCTGGGTTCAGGCTGCTTCGGTGTGGTGCACCGAGGGCTGTGGACGCTGCCCAGTGGC
AAGAGTGTCCCAGTGGCTGTCAAGTCCCTCCGGGTAGGTCCCGAAGGCCCGATGGGCACA
GAACTGGGGGACTTCCTGCGAGAGGTATCGGTCATGATGAACTTGGAGCACCCACACGTG
CTGCGTCTGCACGGCCTTGTACTGGGCCAGCCTCTGCAGATGGTGATGGAGCTGGCGCCA
CTGGGCTCCCTGCACGCGCGCTTAACGGCCCCGGCCCCGACACCCCCGCTGCTCGTGGCC
CTGCTCTGCCTCTTCCTGCGGCAGCTGGCGGGAGCCATGGCGTACCTGGGGGCCCGCGGG
CTGGTGCACCGAGACCTCGCTACGCGCAACCTACAGCTGGCGTCGCCGCGCACCATCAAG
GTGGCTGACTTCGGGCTGGTGCGGCCTCTGGGCGGTGCCCGGGGCCGCTACGTCATGGGC
GGGCCCCGCCCTATCCCCTACACCTGGTGTGCCCCAGAGAGCCTGCGCCACGGAGCCTTC
TCGTCTGCCTCGGACGTGTGGATGTTTGGGGTGACGCTGTGGGAGATGTTCTCCGGGGGC
GAGGAACCCTGGCCCGGGGTCCCACCGTACCTCATCCTGCAGCGGCTGGAGGACAGAGCC
CGGCTGCCTAGGCCTCCCCCCTCCTCCAGGGCCCTCTACTCCCTCGCCTTGCGCTGCTGG
GCCCCCCACCCTGCCGACCGGCCTAGCTTTTCCCACCTGGAGGGGCTGCTGCAAGAGGCC
GGGCCTTCGGAAGCATGTTGTGTGAGGGATGCCACAGAACCAGGCGCCCTGAGGATGGAG
ACTGGTGACCCCATCACAGTCATCGAGGGCAGCTCCTCTTTCCACAGCCCCGACTCCACA
ATCTGGAAGGACCAGAATGGTCGCACCTTCAAAGTGGGCAGCTTCCCAGCCTCGGCAGTG
ACGCTGACAGATGCGGGGGGCTTGCCAGCCACCCGTCCAGTCCACAGAGGCACCCCTGCC
CGGGGAGATCAACACCCAGGAAGCATAGATGGAGACAGAAAGAAGGCAAATCTTTGGGAT
GCGCCCCCAGCACGGGGCCAGAGGAGGAACATGCCCCTGGAGAGGATGAAAGGCATTTCC
AGGAGTCTGGAGTCAGTTCTGTCCCTCGGTCCTCGTCCCACAGGGGGTGGTTCAAGCCCC
CCTGAAATTCGACAAGCCAGAGCTGTGCCCCAGGGACCTCCAGGCCTGCCTCCACGCCCA
CCTTTATCCTCTAGCTCTCCTCAGCCCAGCCAGCCCTCTAGGGAGAGGCTTCCCTGGCCC
GAAAGAAAACCCCCACACAATCACCCCATGGGAATGCCTGGAGCCCGTAAAGCCGCTGCC
CTCTCTGGAGGCCTCTTGTCCGATCCTGAGTTGCAGAGGAAGATTATGGAAATGGAGCTG
AGTGTGCATTGGGTCACCCACCAGGAGTGCCAGACAGCACTAGGAGCCACTGGGGGAGAT
GTGGCTTCTGCCATCCGGAACCTCAAGGTAGATCAGCTCTTCCTCCTGAGTAGCCGGTCC
AGAGCTGACTGCTGGCGCATCCTGGAGCATTACCAGTGGGACCTCTCAGCTGCCAGCCGT
TATGTCCTGGCCAGGCCCTGA

Protein Properties

Number of Residues

666

Molecular Weight

72467.0

Theoretical pI

9.94

Pfam Domain Function

Pkinase_Tyr (PF07714 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Non-receptor tyrosine-protein kinase TNK1
MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDST
IWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWD
APPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRP
PLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVEL
SVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASR
YVLARP

External Links

GenBank ID Protein

1256003

UniProtKB/Swiss-Prot ID

Q13470

UniProtKB/Swiss-Prot Entry Name

TNK1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

U43408

GeneCard ID