| Identification |
|---|
| HMDB Protein ID
| CDBP01206 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inositol polyphosphate multikinase |
| Description
| Not Available |
| Synonyms
|
- Inositol 1,3,4,6-tetrakisphosphate 5-kinase
|
| Gene Name
| IPMK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in inositol trisphosphate 3-kinase activity |
| Specific Function
| Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).
|
| GO Classification
|
| Biological Process |
| neural tube formation |
| inositol phosphate biosynthetic process |
| Cellular Component |
| nucleus |
| Function |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| inositol or phosphatidylinositol kinase activity |
| inositol trisphosphate kinase activity |
| inositol trisphosphate 3-kinase activity |
| catalytic activity |
| transferase activity |
| Molecular Function |
| ATP binding |
| inositol-1,4,5-trisphosphate 3-kinase activity |
| inositol tetrakisphosphate 3-kinase activity |
| inositol-1,4,5-trisphosphate 6-kinase activity |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Inositol Phosphate Metabolism |    |  | | Inositol Metabolism |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q21.1 |
| SNPs
| IPMK |
| Gene Sequence
|
>1251 bp
ATGGCAACAGAGCCACCATCCCCCCTCCGGGTCGAGGCGCCGGGCCCCCCAGAAATGCGG
ACCTCACCGGCGATCGAGTCCACCCCTGAGGGCACCCCGCAGCCGGCGGGCGGCAGACTC
CGCTTCCTCAACGGCTGCGTGCCCCTCTCGCATCAGGTGGCCGGGCACATGTACGGGAAG
GACAAAGTGGGTATACTGCAACATCCAGATGGCACAGTTTTGAAACAGTTACAACCACCT
CCAAGGGGCCCAAGAGAGCTGGAATTCTATAATATGGTTTATGCTGCTGACTGTTTTGAT
GGTGTTCTTCTAGAGCTACGAAAATATTTGCCAAAATATTATGGCATCTGGTCACCTCCC
ACTGCACCAAACGATTTATACCTAAAACTGGAAGATGTGACCCATAAATTTAATAAGCCC
TGTATAATGGATGTAAAGATAGGGCAAAAAAGCTATGATCCTTTTGCCTCATCTGAGAAG
ATTCAGCAACAGGTCAGCAAGTACCCATTAATGGAAGAGATTGGGTTCTTGGTGCTTGGC
ATGAGGGTTTATCATGTTCATTCCGATAGCTATGAGACAGAAAACCAGCATTACGGAAGA
AGCTTAACAAAAGAAACTATAAAGGATGGAGTCTCCAGATTTTTTCATAATGGGTACTGC
TTAAGAAAAGATGCTGTTGCTGCCAGTATTCAGAAGATTGAGAAAATTCTGCAGTGGTTT
GAAAACCAGAAGCAGCTTAATTTTTACGCAAGTTCATTACTCTTTGTTTATGAAGGTTCA
TCTCAGCCAACCACTACAAAATTGAATGACAGAACTTTGGCAGAAAAGTTTTTGTCCAAA
GGACAACTGTCAGACACAGAAGTACTAGAGTACAATAATAACTTTCATGTGTTAAGTTCC
ACAGCTAATGGAAAAATAGAGTCTTCAGTGGGCAAAAGCTTGTCCAAGATGTATGCGCGT
CACAGGAAAATATATACAAAAAAGCATCACAGTCAGACTTCATTGAAAGTTGAAAATCTG
GAGCAAGACAATGGGTGGAAAAGCATGTCACAGGAACATTTAAATGGAAATGTACTTTCC
CAACTGGAAAAAGTTTTCTACCATCTTCCCACTGGTTGCCAAGAGATTGCTGAAGTAGAA
GTGCGAATGATAGATTTTGCTCATGTGTTCCCTAGCAACACAATAGATGAGGGATATGTT
TATGGGCTAAAGCATTTAATTTCTGTACTTCGAAGTATTTTAGACAATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 416 |
| Molecular Weight
| 47221.455 |
| Theoretical pI
| 7.634 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inositol polyphosphate multikinase
MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLNGCVPLSHQVAGHMYGK
DKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPP
TAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLG
MRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWF
ENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEKFLSKGQLSDTEVLEYNNNFHVLSS
TANGKIESSVGKSLSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQEHLNGNVLS
QLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN
|
| External Links |
|---|
| GenBank ID Protein
| 22532105 |
| UniProtKB/Swiss-Prot ID
| Q8NFU5 |
| UniProtKB/Swiss-Prot Entry Name
| IPMK_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF432853 |
| GeneCard ID
| IPMK |
| GenAtlas ID
| IPMK |
| HGNC ID
| HGNC:20739 |
| References |
|---|
| General References
| Not Available |