| Identification |
|---|
| HMDB Protein ID
| CDBP01169 |
| Secondary Accession Numbers
| Not Available |
| Name
| Insulin receptor-related protein |
| Description
| Not Available |
| Synonyms
|
- IR-related receptor
- IRR
- Insulin receptor-related protein alpha chain
- Insulin receptor-related protein beta chain
|
| Gene Name
| INSRR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane receptor protein tyrosine kinase activity |
| Specific Function
| This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2 |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein binding |
| protein kinase activity |
| protein tyrosine kinase activity |
| transmembrane receptor protein tyrosine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| Process |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| phosphorylation |
| phosphorus metabolic process |
| phosphate metabolic process |
| enzyme linked receptor protein signaling pathway |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| metabolic process |
| protein amino acid autophosphorylation |
| cellular metabolic process |
| protein amino acid phosphorylation |
| signaling |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21-q23 |
| SNPs
| INSRR |
| Gene Sequence
|
>3894 bp
ATGGCAGTGCCTAGTCTGTGGCCCTGGGGAGCATGCCTGCCTGTGATCTTCCTCTCCTTG
GGATTTGGCCTGGATACAGTAGAGGTGTGCCCCAGCCTGGATATTCGCTCAGAGGTGGCA
GAGCTTCGTCAGCTGGAGAACTGCAGCGTGGTGGAGGGCCACCTGCAGATCCTGCTCATG
TTCACAGCCACCGGGGAGGACTTCCGCGGCCTCAGCTTCCCTCGCCTCACCCAGGTCACC
GACTACCTGCTGCTCTTCCGTGTCTACGGACTGGAGAGCCTGCGCGACCTCTTCCCCAAC
CTAGCAGTCATCCGCGGGACGCGCCTCTTCCTGGGCTATGCACTGGTCATCTTTGAGATG
CCACATCTGCGTGACGTGGCACTGCCTGCACTTGGGGCCGTGCTGCGTGGGGCTGTGCGT
GTGGAGAAGAACCAGGAGCTCTGCCACCTCTCCACCATTGACTGGGGACTGCTGCAGCCA
GCACCTGGCGCCAACCACATCGTGGGCAACAAGCTGGGCGAGGAGTGTGCTGACGTGTGC
CCTGGTGTGCTGGGTGCTGCTGGTGAGCCCTGTGCCAAGACCACCTTCAGCGGGCACACT
GACTACAGATGCTGGACCTCCAGCCACTGCCAGAGAGTGTGCCCCTGCCCCCATGGGATG
GCTTGCACAGCGAGGGGCGAGTGCTGCCACACCGAATGCCTGGGGGGCTGCAGCCAGCCA
GAAGACCCTCGTGCCTGTGTAGCTTGCCGCCACCTCTACTTCCAGGGTGCCTGCCTGTGG
GCCTGCCCGCCAGGCACCTACCAGTATGAGTCCTGGCGCTGTGTCACAGCTGAGCGCTGT
GCCAGCCTGCACTCTGTGCCCGGCCGTGCCTCCACCTTCGGCATACACCAGGGCAGTTGC
CTGGCCCAGTGCCCTTCTGGCTTCACCCGTAATAGCAGCAGCATATTCTGCCACAAGTGC
GAGGGGCTGTGCCCTAAAGAGTGCAAGGTAGGCACCAAGACCATCGACTCCATCCAGGCG
GCACAGGATCTTGTGGGCTGCACGCATGTGGAGGGAAGCCTCATCCTCAACCTTCGCCAG
GGCTACAACCTGGAGCCACAGCTGCAGCACAGCCTGGGGCTGGTAGAAACCATTACTGGC
TTCCTCAAAATCAAGCACTCCTTTGCCCTCGTGTCCCTGGGCTTTTTCAAGAACCTCAAA
CTAATCCGGGGAGACGCCATGGTGGATGGGAACTACACTCTCTACGTGCTGGACAACCAG
AACCTACAACAGCTAGGGTCCTGGGTGGCCGCGGGGCTCACCATTCCCGTGGGCAAGATC
TACTTCGCCTTCAACCCGCGCCTCTGCTTGGAACACATCTACCGACTGGAGGAGGTGACA
GGCACGCGAGGTCGGCAGAACAAGGCTGAGATCAACCCCCGCACCAACGGAGACCGCGCC
GCCTGCCAGACTCGCACCCTGCGCTTCGTGTCCAACGTGACGGAGGCAGACCGCATCCTG
CTACGCTGGGAGCGCTATGAGCCACTGGAGGCCCGCGACCTGCTCAGCTTCATCGTGTAC
TACAAGGAGTCCCCATTCCAGAACGCCACAGAGCACGTGGGTCCAGATGCTTGTGGAACC
CAGAGCTGGAACCTGCTGGATGTGGAGCTGCCCCTAAGCCGCACCCAGGAGCCAGGGGTG
ACCCTAGCCTCCCTCAAGCCTTGGACACAGTACGCAGTGTTTGTGCGGGCCATCACGCTA
ACCACTGAGGAGGACAGCCCTCATCAAGGAGCCCAGAGTCCCATCGTCTACCTCCGAACG
CTGCCTGCAGCTCCCACGGTGCCCCAAGACGTCATCTCCACGTCCAACTCCTCCTCCCAC
CTCCTGGTGCGCTGGAAGCCACCGACCCAGCGCAATGGGAACCTCACCTACTACCTGGTG
CTGTGGCAGCGGCTGGCAGAGGACGGCGACCTCTACCTCAATGACTACTGCCACCGCGGC
TTGCGGCTGCCCACCAGCAACAACGATCCGCGCTTCGACGGCGAAGACGGGGATCCTGAG
GCCGAGATGGAGTCCGACTGCTGCCCTTGCCAGCACCCACCTCCTGGTCAGGTTCTGCCC
CCGCTGGAGGCGCAAGAGGCCTCGTTCCAGAAGAAGTTTGAAAACTTTCTACACAACGCG
ATCACCATCCCCATATCCCCTTGGAAGGTGACGTCCATCAACAAGAGCCCCCAAAGGGAC
TCAGGGCGGCACCGCCGGGCAGCTGGGCCCCTCCGGCTGGGGGGCAACAGCTCGGATTTC
GAGATCCAGGAGGACAAGGTGCCCCGTGAGCGAGCGGTGCTGAGCGGCCTGCGCCACTTC
ACGGAATACCGGATCGACATCCATGCCTGCAACCACGCGGCGCACACCGTGGGCTGCAGC
GCCGCCACCTTCGTCTTTGCGCGCACCATGCCCCACAGAGAGGCTGATGGTATTCCAGGA
AAGGTGGCCTGGGAGGCCTCCAGCAAGAACAGTGTCCTTCTGCGCTGGCTCGAGCCACCA
GACCCCAACGGACTCATCCTCAAGTACGAAATCAAGTACCGCCGCTTGGGAGAGGAGGCC
ACAGTGCTGTGTGTGTCCCGTCTTCGATATGCGAAGTTTGGGGGAGTCCACCTGGCCCTG
CTGCCCCCTGGAAACTACTCTGCCAGGGTTAGGGCAACCTCACTGGCTGGCAATGGCTCT
TGGACAGACAGTGTTGCCTTCTACATCCTTGGCCCAGAGGAGGAGGATGCTGGGGGGCTG
CATGTCCTCCTCACTGCCACCCCTGTGGGGCTCACGCTGCTCATCGTTCTTGCTGCCCTT
GGTTTCTTCTACGGCAAGAAGAGAAACAGAACCCTGTATGCTTCTGTGAATCCAGAGTAC
TTCAGCGCCTCTGATATGTATGTCCCTGATGAATGGGAGGTGCCTCGGGAGCAGATCTCG
ATAATCCGGGAACTGGGCCAGGGCTCTTTTGGGATGGTATATGAGGGGCTGGCACGAGGA
CTTGAGGCTGGAGAGGAGTCCACACCCGTGGCCCTGAAGACGGTGAATGAGCTGGCCAGC
CCACGGGAATGCATTGAGTTCCTCAAGGAAGCTTCTGTCATGAAAGCCTTCAAGTGTCAC
CATGTGGTGCGTCTCCTGGGTGTGGTATCTCAGGGCCAGCCAACTCTGGTCATCATGGAG
TTAATGACCCGTGGGGACCTCAAGAGCCATCTTCGATCTTTGCGGCCTGAGGCAGAGAAC
AACCCTGGGCTCCCACAGCCAGCATTGGGGGAAATGATCCAAATGGCTGGTGAGATTGCA
GACGGCATGGCCTACCTTGCTGCCAACAAGTTTGTGCACCGAGATCTAGCAGCCCGCAAC
TGCATGGTGTCCCAGGACTTCACCGTCAAGATCGGGGACTTCGGGATGACTCGGGACGTG
TATGAGACAGACTATTACCGCAAGGGTGGGAAGGGGCTGCTGCCCGTGCGCTGGATGGCC
CCCGAGTCCCTCAAAGATGGGATCTTCACCACCCACTCGGATGTCTGGTCCTTTGGCGTG
GTACTCTGGGAGATTGTGACCCTGGCAGAACAACCCTACCAGGGCCTGTCCAATGAGCAG
GTGCTGAAGTTCGTCATGGATGGCGGGGTCCTGGAGGAGCTGGAGGGCTGTCCCCTTCAG
CTGCAGGAGCTGATGAGCCGCTGCTGGCAGCCGAACCCACGCCTGCGCCCATCTTTCACA
CACATTCTGGACAGCATACAGGAGGAGCTGCGGCCCTCCTTCCGCCTCCTCTCCTTCTAC
TACAGCCCGGAATGCCGGGGGGCCCGGGGCTCCCTGCCTACCACCGATGCAGAGCCTGAC
TCCTCACCCACTCCAAGAGACTGCAGCCCTCAAAATGGGGGTCCAGGGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1297 |
| Molecular Weight
| 143718.7 |
| Theoretical pI
| 6.44 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Insulin receptor-related protein
MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLM
FTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEM
PHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVC
PGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQP
EDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSC
LAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQ
GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ
NLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRA
ACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGT
QSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRT
LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRG
LRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNA
ITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHF
TEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPP
DPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGS
WTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEY
FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELAS
PRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN
NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV
YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQ
VLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFY
YSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH
|
| External Links |
|---|
| GenBank ID Protein
| 31657140 |
| UniProtKB/Swiss-Prot ID
| P14616 |
| UniProtKB/Swiss-Prot Entry Name
| INSRR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014215.1 |
| GeneCard ID
| INSRR |
| GenAtlas ID
| INSRR |
| HGNC ID
| HGNC:6093 |
| References |
|---|
| General References
| Not Available |