| Identification |
|---|
| HMDB Protein ID
| CDBP01164 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein kinase pim-3 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| PIM3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| Able to phosphorylate CDKN1B in vitro. Involved in cell cycle progression and suppression of apoptosis. Implicated in proliferation of human hepatoma cell lines |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| protein serine/threonine kinase activity |
| Process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q13 |
| SNPs
| PIM3 |
| Gene Sequence
|
>981 bp
ATGCTGCTCTCCAAGTTCGGCTCCCTGGCGCACCTCTGCGGGCCCGGCGGCGTGGACCAC
CTCCCGGTGAAGATCCTGCAGCCAGCCAAGGCGGACAAGGAGAGCTTCGAGAAGGCGTAC
CAGGTGGGCGCCGTGCTGGGTAGCGGCGGCTTCGGCACGGTCTACGCGGGTAGCCGCATC
GCCGACGGGCTCCCGGTGGCTGTGAAGCACGTGGTGAAGGAGCGGGTGACCGAGTGGGGC
AGCCTGGGCGGCGCGACCGTGCCCCTGGAGGTGGTGCTGCTGCGCAAGGTGGGCGCGGCG
GGCGGCGCGCGCGGCGTCATCCGCCTGCTGGACTGGTTCGAGCGGCCCGACGGCTTCCTG
CTGGTGCTGGAGCGGCCCGAGCCGGCGCAGGACCTCTTCGACTTTATCACGGAGCGCGGC
GCCCTGGACGAGCCGCTGGCGCGCCGCTTCTTCGCGCAGGTGCTGGCCGCCGTGCGCCAC
TGCCACAGCTGCGGGGTCGTGCACCGCGACATTAAGGACGAAAATCTGCTTGTGGACCTG
CGCTCCGGAGAGCTCAAGCTCATCGACTTCGGTTCGGGTGCGCTGCTCAAGGACACGGTC
TACACCGACTTCGACGGCACCCGAGTGTACAGCCCCCCGGAGTGGATCCGCTACCACCGC
TACCACGGGCGCTCGGCCACCGTGTGGTCGCTGGGCGTGCTTCTCTACGATATGGTGTGT
GGGGACATCCCCTTCGAGCAGGACGAGGAGATCCTCCGAGGCCGCCTGCTCTTCCGGAGG
AGGGTCTCTCCAGAGTGCCAGCAGCTGATCCGGTGGTGCCTGTCCCTGCGGCCCTCAGAG
CGGCCGTCGCTGGATCAGATTGCGGCCCATCCCTGGATGCTGGGGGCTGACGGGGGCGCC
CCGGAGAGCTGTGACCTGCGGCTGTGCACCCTCGACCCTGATGACGTGGCCAGCACCACG
TCCAGCAGCGAGAGCTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 326 |
| Molecular Weight
| 35890.8 |
| Theoretical pI
| 6.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Serine/threonine-protein kinase pim-3
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
|
| External Links |
|---|
| GenBank ID Protein
| 51870677 |
| UniProtKB/Swiss-Prot ID
| Q86V86 |
| UniProtKB/Swiss-Prot Entry Name
| PIM3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB114795 |
| GeneCard ID
| PIM3 |
| GenAtlas ID
| PIM3 |
| HGNC ID
| HGNC:19310 |
| References |
|---|
| General References
| Not Available |