Identification |
HMDB Protein ID
| CDBP01141 |
Secondary Accession Numbers
| Not Available |
Name
| ATP synthase subunit delta, mitochondrial |
Description
| Not Available |
Synonyms
|
- F-ATPase delta subunit
|
Gene Name
| ATP5D |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism |
Specific Function
| Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits |
GO Classification
|
Component |
proton-transporting atp synthase complex, catalytic core f(1) |
proton-transporting two-sector atpase complex, catalytic domain |
macromolecular complex |
protein complex |
Function |
proton-transporting atpase activity, rotational mechanism |
hydrogen ion transporting atp synthase activity, rotational mechanism |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
cation transmembrane transporter activity |
inorganic cation transmembrane transporter activity |
monovalent inorganic cation transmembrane transporter activity |
hydrogen ion transmembrane transporter activity |
transporter activity |
Process |
cellular nitrogen compound metabolic process |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
nucleobase, nucleoside and nucleotide metabolic process |
nucleoside phosphate metabolic process |
nucleotide metabolic process |
atp synthesis coupled proton transport |
atp biosynthetic process |
purine nucleotide metabolic process |
purine nucleotide biosynthetic process |
purine nucleoside triphosphate biosynthetic process |
purine ribonucleoside triphosphate biosynthetic process |
metabolic process |
nitrogen compound metabolic process |
|
Cellular Location
|
- Mitochondrion
- Mitochondrion inner membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Mitochondrial Electron Transport Chain | | |
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 19p13.3 |
SNPs
| ATP5D |
Gene Sequence
|
>507 bp
ATGCTGCCCGCCGCGCTGCTCCGCCGCCCGGGACTTGGCCGCCTCGTCCGCCACGCCCGT
GCCTATGCCGAGGCCGCCGCCGCCCCGGCTGCCGCCTCTGGCCCCAACCAGATGTCCTTC
ACCTTCGCCTCTCCCACGCAGGTGTTCTTCAACGGTGCCAACGTCCGGCAGGTGGACGTG
CCCACGCTGACCGGAGCCTTCGGCATCCTGGCGGCCCACGTGCCCACGCTGCAGGTCCTG
CGGCCGGGGCTGGTCGTGGTGCATGCAGAGGACGGCACCACCTCCAAATACTTTGTGAGC
AGCGGTTCCATCGCAGTGAACGCCGACTCTTCGGTGCAGTTGTTGGCCGAAGAGGCCGTG
ACGCTGGACATGTTGGACCTGGGGGCAGCCAAGGCAAACTTGGAGAAGGCCCAGGCGGAG
CTGGTGGGGACAGCTGACGAGGCCACGCGGGCAGAGATCCAGATCCGAATCGAGGCCAAC
GAGGCCCTGGTGAAGGCCCTGGAGTAG
|
Protein Properties |
Number of Residues
| 168 |
Molecular Weight
| 17489.8 |
Theoretical pI
| 5.19 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>ATP synthase subunit delta, mitochondrial
MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFASPTQVFFNGANVRQVDV
PTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSIAVNADSSVQLLAEEAV
TLDMLDLGAAKANLEKAQAELVGTADEATRAEIQIRIEANEALVKALE
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P30049 |
UniProtKB/Swiss-Prot Entry Name
| ATPD_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| S87916 |
GeneCard ID
| ATP5D |
GenAtlas ID
| ATP5D |
HGNC ID
| HGNC:837 |
References |
General References
| Not Available |