Identification |
HMDB Protein ID
| CDBP01113 |
Secondary Accession Numbers
| Not Available |
Name
| Ephrin type-B receptor 1 |
Description
| Not Available |
Synonyms
|
- EK6
- ELK
- EPH-like kinase 6
- NET
- Tyrosine-protein kinase receptor EPH-2
- hEK6
|
Gene Name
| EPHB1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in ephrin receptor activity |
Specific Function
| Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system |
GO Classification
|
Component |
integral to plasma membrane |
membrane |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
ephrin receptor activity |
protein binding |
protein kinase activity |
protein tyrosine kinase activity |
transmembrane receptor protein tyrosine kinase activity |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
nucleoside binding |
Process |
cell surface receptor linked signaling pathway |
phosphorylation |
phosphorus metabolic process |
phosphate metabolic process |
enzyme linked receptor protein signaling pathway |
transmembrane receptor protein tyrosine kinase signaling pathway |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
signaling |
signaling pathway |
|
Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:3 |
Locus
| 3q21-q23 |
SNPs
| EPHB1 |
Gene Sequence
|
>2955 bp
ATGGCCCTGGATTATCTACTACTGCTCCTCCTGGCATCCGCAGTGGCTGCGATGGAAGAA
ACGTTAATGGACACCAGAACGGCTACTGCAGAGCTGGGCTGGACGGCCAATCCTGCGTCC
GGGTGGGAAGAAGTCAGTGGCTACGATGAAAACCTGAACACCATCCGCACCTACCAGGTG
TGCAATGTCTTCGAGCCCAACCAGAACAATTGGCTGCTCACCACCTTCATCAACCGGCGG
GGGGCCCATCGCATCTACACAGAGATGCGCTTCACTGTGAGAGACTGCAGCAGCCTCCCT
AATGTCCCAGGATCCTGCAAGGAGACCTTCAACTTGTATTACTATGAGACTGACTCTGTC
ATTGCCACCAAGAAGTCAGCCTTCTGGTCTGAGGCCCCCTACCTCAAAGTAGACACCATT
GCTGCAGATGAGAGCTTCTCCCAGGTGGACTTTGGGGGAAGGCTGATGAAGGTAAACACA
GAAGTCAGGAGCTTTGGGCCTCTTACTCGGAATGGTTTTTACCTCGCTTTTCAGGATTAT
GGAGCCTGTATGTCTCTTCTTTCTGTCCGTGTCTTCTTCAAAAAGTGTCCCAGCATTGTG
CAAAATTTTGCAGTGTTTCCAGAGACTATGACAGGGGCAGAGAGCACATCTCTGGTGATT
GCTCGGGGCACATGCATCCCCAACGCAGAGGAAGTGGACGTGCCCATCAAACTCTACTGC
AACGGGGATGGGGAATGGATGGTGCCTATTGGGCGATGCACCTGCAAGCCTGGCTATGAG
CCTGAGAACAGCGTGGCATGCAAGGCTTGCCCTGCAGGGACATTCAAGGCCAGCCAGGAA
GCTGAAGGCTGCTCCCACTGCCCCTCCAACAGCCGCTCCCCTGCAGAGGCGTCTCCCATC
TGCACCTGTCGGACCGGTTATTACCGAGCGGACTTTGACCCTCCAGAAGTGGCATGCACT
AGCGTCCCATCAGGTCCCCGCAATGTTATCTCCATCGTCAATGAGACGTCCATCATTCTG
GAGTGGCACCCTCCAAGGGAGACAGGTGGGCGGGATGATGTGACCTACAACATCATCTGC
AAAAAGTGCCGGGCAGACCGCCGGAGCTGCTCCCGCTGTGACGACAATGTGGAGTTTGTG
CCCAGGCAGCTGGGCCTGACGGAGTGCCGCGTCTCCATCAGCAGCCTGTGGGCCCACACC
CCCTACACCTTTGACATCCAGGCCATCAATGGAGTCTCCAGCAAGAGTCCCTTCCCCCCA
CAGCACGTCTCTGTCAACATCACCACAAACCAAGCCGCCCCCTCCACCGTTCCCATCATG
CACCAAGTCAGTGCCACTATGAGGAGCATCACCTTGTCATGGCCACAGCCGGAGCAGCCC
AATGGCATCATCCTGGACTATGAGATCCGGTACTATGAGAAGGAACACAATGAGTTCAAC
TCCTCCATGGCCAGGAGTCAGACCAACACAGCAAGGATTGATGGGCTGCGGCCTGGCATG
GTATATGTGGTACAGGTGCGTGCCCGCACTGTTGCTGGCTACGGCAAGTTCAGTGGCAAG
ATGTGCTTCCAGACTCTGACTGACGATGATTACAAGTCAGAGCTGAGGGAGCAGCTGCCC
CTGATTGCTGGCTCGGCAGCGGCCGGGGTCGTGTTCGTTGTGTCCTTGGTGGCCATCTCT
ATCGTCTGTAGCAGGAAACGGGCTTATAGCAAAGAGGCTGTGTACAGCGATAAGCTCCAG
CATTACAGCACAGGCCGAGGCTCCCCAGGGATGAAGATCTACATTGACCCCTTCACTTAC
GAGGATCCCAACGAAGCTGTCCGGGAGTTTGCCAAGGAGATTGATGTATCTTTTGTGAAA
ATTGAAGAGGTCATCGGAGCAGGGGAGTTTGGAGAAGTGTACAAGGGGCGTTTGAAACTG
CCAGGCAAGAGGGAAATCTACGTGGCCATCAAGACCCTGAAGGCAGGGTACTCGGAGAAG
CAGCGTCGGGACTTTCTGAGTGAGGCGAGCATCATGGGCCAGTTCGACCATCCTAACATC
ATTCGCCTGGAGGGTGTGGTCACCAAGAGTCGGCCTGTCATGATCATCACAGAGTTCATG
GAGAATGGTGCATTGGATTCTTTCCTCAGGCAAAATGACGGGCAGTTCACCGTGATCCAG
CTTGTGGGTATGCTCAGGGGCATCGCTGCTGGCATGAAGTACCTGGCTGAGATGAATTAT
GTGCATCGGGACCTGGCTGCTAGGAACATTCTGGTCAACAGTAACCTGGTGTGCAAGGTG
TCCGACTTTGGCCTCTCCCGCTACCTCCAGGATGACACCTCAGATCCCACCTACACCAGC
TCCTTGGGAGGGAAGATCCCTGTGAGATGGACAGCTCCAGAGGCCATCGCCTACCGCAAG
TTCACTTCAGCCAGCGACGTTTGGAGCTATGGGATCGTCATGTGGGAAGTCATGTCATTT
GGAGAGAGACCCTATTGGGATATGTCCAACCAAGATGTCATCAATGCCATCGAGCAGGAC
TACCGGCTGCCCCCACCCATGGACTGTCCAGCTGCTCTACACCAGCTCATGCTGGACTGT
TGGCAGAAGGACCGGAACAGCCGGCCCCGGTTTGCGGAGATTGTCAACACCCTAGATAAG
ATGATCCGGAACCCGGCAAGTCTCAAGACTGTGGCAACCATCACCGCCGTGCCTTCCCAG
CCCCTGCTCGACCGCTCCATCCCAGACTTCACGGCCTTTACCACCGTGGATGACTGGCTC
AGCGCCATCAAAATGGTCCAGTACAGGGACAGCTTCCTCACTGCTGGCTTCACCTCCCTC
CAGCTGGTCACCCAGATGACATCAGAAGACCTCCTGAGAATAGGCATCACCTTGGCAGGC
CATCAGAAGAAGATCCTGAACAGCATTCATTCTATGAGGGTCCAGATAAGTCAGTCACCA
ACGGCAATGGCATGA
|
Protein Properties |
Number of Residues
| 984 |
Molecular Weight
| 109884.2 |
Theoretical pI
| 6.34 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Ephrin type-B receptor 1
MALDYLLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQV
CNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSV
IATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDY
GACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYC
NGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPI
CTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIIC
KKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPP
QHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFN
SSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLP
LIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTY
EDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK
QRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ
LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTS
SLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD
YRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQ
PLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAG
HQKKILNSIHSMRVQISQSPTAMA
|
External Links |
GenBank ID Protein
| 4758284 |
UniProtKB/Swiss-Prot ID
| P54762 |
UniProtKB/Swiss-Prot Entry Name
| EPHB1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| NM_004441.4 |
GeneCard ID
| EPHB1 |
GenAtlas ID
| EPHB1 |
HGNC ID
| HGNC:3392 |
References |
General References
| Not Available |