| Identification |
|---|
| HMDB Protein ID
| CDBP01094 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein kinase CLK4 |
| Description
| Not Available |
| Synonyms
|
- CDC-like kinase 4
|
| Gene Name
| CLK4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Required for the regulation of alternative splicing of MAPT/TAU |
| GO Classification
|
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| protein serine/threonine kinase activity |
| binding |
| Process |
| phosphorylation |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q35 |
| SNPs
| CLK4 |
| Gene Sequence
|
>1446 bp
ATGCGGCATTCCAAAAGAACTCACTGTCCTGATTGGGATAGCAGAGAAAGCTGGGGACAT
GAAAGCTATCGTGGAAGTCACAAGCGGAAGAGGAGATCTCATAGTAGCACACAAGAGAAC
AGGCATTGTAAACCACATCACCAGTTTAAAGAATCTGATTGTCATTATTTAGAAGCAAGG
TCCTTGAATGAGCGAGATTATCGGGACCGGAGATACGTTGACGAATACAGGAATGACTAC
TGTGAAGGATATGTTCCTAGACATTATCACAGAGACATTGAAAGCGGGTATCGAATCCAC
TGCAGTAAATCTTCAGTCCGCAGCAGGAGAAGCAGTCCTAAAAGGAAGCGCAATAGACAC
TGTTCAAGTCATCAGTCACGTTCGAAGAGCCACCGAAGGAAAAGATCCAGGAGTATAGAG
GATGATGAGGAGGGTCACCTGATCTGTCAAAGTGGAGACGTTCTAAGAGCAAGATATGAA
ATCGTGGACACTTTGGGTGAAGGAGCCTTTGGCAAAGTTGTAGAGTGCATTGATCATGGC
ATGGATGGCATGCATGTAGCAGTGAAAATCGTAAAAAATGTAGGCCGTTACCGTGAAGCA
GCTCGTTCAGAAATCCAAGTATTAGAGCACTTAAATAGTACTGATCCCAATAGTGTCTTC
CGATGTGTCCAGATGCTAGAATGGTTTGATCATCATGGTCATGTTTGTATTGTGTTTGAA
CTACTGGGACTTAGTACTTACGATTTCATTAAAGAAAACAGCTTTCTGCCATTTCAAATT
GACCACATCAGGCAGATGGCGTATCAGATCTGCCAGTCAATAAATTTTTTACATCATAAT
AAATTAACCCATACAGATCTGAAGCCTGAAAATATTTTGTTTGTGAAGTCTGACTATGTA
GTCAAATATAATTCTAAAATGAAACGTGATGAACGCACACTGAAAAACACAGATATCAAA
GTTGTTGACTTTGGAAGTGCAACGTATGATGATGAACATCACAGTACTTTGGTGTCTACC
CGGCACTACAGAGCTCCCGAGGTCATTTTGGCTTTAGGTTGGTCTCAGCCTTGTGATGTT
TGGAGCATAGGTTGCATTCTTATTGAATATTACCTTGGTTTCACAGTCTTTCAGACTCAT
GATAGTAAAGAGCACCTGGCAATGATGGAACGAATATTAGGACCCATACCACAACACATG
ATTCAGAAAACAAGAAAACGCAAGTATTTTCACCATAACCAGCTAGATTGGGATGAACAC
AGTTCTGCTGGTAGATATGTTAGGAGACGCTGCAAACCGTTGAAGGAATTTATGCTTTGT
CATGATGAAGAACATGAGAAACTGTTTGACCTGGTTCGAAGAATGTTAGAATATGATCCA
ACTCAAAGAATTACCTTGGATGAAGCATTGCAGCATCCTTTCTTTGACTTATTAAAAAAG
AAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 481 |
| Molecular Weight
| 57491.5 |
| Theoretical pI
| 8.82 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dual specificity protein kinase CLK4
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
|
| External Links |
|---|
| GenBank ID Protein
| 9965398 |
| UniProtKB/Swiss-Prot ID
| Q9HAZ1 |
| UniProtKB/Swiss-Prot Entry Name
| CLK4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF294429 |
| GeneCard ID
| CLK4 |
| GenAtlas ID
| CLK4 |
| HGNC ID
| HGNC:13659 |
| References |
|---|
| General References
| Not Available |