| Identification |
|---|
| HMDB Protein ID
| CDBP01093 |
| Secondary Accession Numbers
| Not Available |
| Name
| Katanin p60 ATPase-containing subunit A1 |
| Description
| Not Available |
| Synonyms
|
- Katanin p60 subunit A1
- p60 katanin
|
| Gene Name
| KATNA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity).
|
| GO Classification
|
| Biological Process |
| cell division |
| cytoplasmic microtubule organization |
| interphase of mitotic cell cycle |
| microtubule bundle formation |
| microtubule severing |
| neuron migration |
| protein localization |
| negative regulation of neuron projection development |
| mitosis |
| Cellular Component |
| spindle pole |
| axon |
| microtubule |
| centrosome |
| growth cone |
| plasma membrane |
| nucleus |
| lipid particle |
| neuronal cell body |
| Function |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| Molecular Function |
| ATP binding |
| microtubule binding |
| microtubule-severing ATPase activity |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm
- Cytoplasm
- cytoskeleton
- cytoskeleton
- centrosome
- spindle pole
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q25.1 |
| SNPs
| KATNA1 |
| Gene Sequence
|
>1476 bp
ATGAGTCTTCTTATGATTAGTGAGAATGTAAAATTGGCTCGTGAATATGCATTGCTGGGA
AACTATGACTCTGCGATGGTCTATTATCAGGGAGTTCTTGACCAAATGAACAAGTATCTG
TACTCAGTCAAAGATACATACCTCCAGCAGAAATGGCAACAGGTTTGGCAGGAAATAAAT
GTGGAAGCTAAACATGTTAAAGATATCATGAAAACACTAGAGAGCTTTAAACTGGACAGC
ACTCCCTTGAAAGCGGCACAGCATGACCTTCCAGCTTCTGAGGGAGAAGTCTGGTCCATG
CCTGTACCTGTTGAACGAAGACCCTCACCAGGACCTAGAAAACGCCAATCTTCTCAGTAC
AGTGACCCTAAATCACATGGTAATCGTCCAAGTACAACTGTCAGAGTTCACCGTTCATCT
GCACAGAATGTTCACAATGACAGAGGGAAAGCTGTTCGTTGTCGTGAAAAGAAAGAACAG
AATAAAGGAAGAGAGGAAAAGAACAAATCACCTGCTGCAGTAACAGAACCAGAGACAAAT
AAATTTGATAGTACCGGATATGATAAAGACTTAGTAGAAGCTTTGGAAAGAGATATAATT
TCCCAGAATCCCAATGTTCGATGGGATGATATCGCTGATTTAGTAGAAGCTAAAAAGTTG
CTTAAGGAAGCCGTAGTGTTACCAATGTGGATGCCCGAATTCTTTAAGGGCATTAGGAGA
CCATGGAAAGGAGTACTGATGGTCGGCCCACCTGGCACGGGGAAGACGCTCCTTGCTAAA
GCAGTAGCTACAGAATGCAAGACAACATTCTTCAATGTCTCTTCATCAACTTTGACTTCC
AAATACAGAGGAGAATCTGAGAAGCTTGTTCGTCTTCTGTTTGAAATGGCTCGATTTTAT
TCTCCAGCCACCATATTTATTGATGAGATAGACTCCATCTGTAGTCGCCGAGGGACTTCT
GAAGAACATGAAGCAAGCAGAAGGGTGAAAGCGGAGCTGCTGGTTCAGATGGATGGTGTT
GGAGGTACTTCTGAAAATGATGACCCTTCCAAAATGGTTATGGTTCTGGCAGCTACTAAT
TTTCCCTGGGATATAGATGAGGCTTTAAGACGACGCCTTGAGAAACGAATCTATATTCCT
TTGCCGTCAGCAAAAGGCAGGGAGGAGCTATTACGAATAAGTCTACGTGAGTTGGAATTG
GCTGATGATGTTGACCTTGCAAGTATAGCAGAAAACATGGAAGGTTATTCAGGTGCGGAC
ATTACCAACGTGTGCAGGGATGCGTCCTTGATGGCAATGAGAAGGCGCATTGAAGGTTTG
ACTCCAGAGGAAATCCGAAATCTTTCCAAAGAAGAAATGCACATGCCTACAACTATGGAG
GATTTCGAGATGGCTTTAAAAAAGGTTTCTAAGTCAGTGTCTGCTGCAGACATTGAAAGA
TACGAGAAATGGATATTTGAGTTTGGATCATGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 491 |
| Molecular Weight
| 35319.06 |
| Theoretical pI
| 9.267 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Katanin p60 ATPase-containing subunit A1
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEIN
VEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQY
SDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETN
KFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRR
PWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFY
SPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATN
FPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGAD
ITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIER
YEKWIFEFGSC
|
| External Links |
|---|
| GenBank ID Protein
| 3283072 |
| UniProtKB/Swiss-Prot ID
| O75449 |
| UniProtKB/Swiss-Prot Entry Name
| KTNA1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF056022 |
| GeneCard ID
| KATNA1 |
| GenAtlas ID
| KATNA1 |
| HGNC ID
| HGNC:6216 |
| References |
|---|
| General References
| Not Available |