| Identification |
|---|
| HMDB Protein ID
| CDBP01086 |
| Secondary Accession Numbers
| Not Available |
| Name
| Myosin-IIIa |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| MYO3A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in motor activity |
| Specific Function
| Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing |
| GO Classification
|
| Component |
| myosin complex |
| macromolecular complex |
| protein complex |
| Function |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| nucleoside-triphosphatase activity |
| protein serine/threonine kinase activity |
| hydrolase activity, acting on acid anhydrides |
| binding |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| catalytic activity |
| pyrophosphatase activity |
| hydrolase activity |
| transferase activity |
| motor activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Cytoplasm
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10p11.1 |
| SNPs
| MYO3A |
| Gene Sequence
|
>4848 bp
ATGTTTCCATTAATTGGAAAAACAATCATCTTTGATAACTTTCCTGATCCTTCTGATACA
TGGGAAATCACTGAGACAATTGGCAAAGGAACTTATGGGAAAGTTTTTAAAGTATTGAAT
AAGAAAAATGGCCAAAAAGCAGCAGTCAAAATTCTTGATCCAATTCACGATATTGACGAA
GAGATTGAAGCAGAATATAACATCTTAAAAGCACTTTCTGACCACCCTAATGTGGTCAGA
TTCTATGGGATATACTTTAAGAAGGATAAAGTAAATGGAGACAAGCTGTGGTTGGTTCTT
GAGCTCTGCAGTGGAGGATCAGTGACTGACCTTGTGAAAGGATTTCTGAAGAGGGGTGAA
AGAATGAGTGAGCCTCTAATTGCCTATATTTTACATGAAGCACTAATGGGACTTCAACAT
TTGCATAACAACAAAACTATCCACAGAGATGTGAAAGGCAATAACATTCTATTGACCACG
GAAGGTGGAGTGAAACTAGTAGATTTTGGTGTGTCTGCACAGCTCACCAGTACCCGGCAC
CGTCGGAACACATCCGTAGGAACACCGTTTTGGATGGCTCCTGAGGTGATTGCATGTGAA
CAGCAATTGGATACCACTTATGACGCCAGATGTGACACTTGGTCCCTGGGTATCACGGCC
ATTGAGCTGGGTGATGGAGATCCTCCACTAGCTGACCTTCATCCCATGAGAGCACTCTTC
AAAATACCAAGGAATCCACCCCCAAAACTAAGGCAGCCTGAGCTATGGTCAGCAGAATTC
AATGACTTCATAAGCAAGTGCTTGACTAAAGATTATGAAAAGCGTCCAACAGTGTCAGAA
CTTTTACAGCATAAATTCATTACTCAAATTGAGGGCAAAGATGTGATGCTACAAAAACAA
CTAACGGAATTCATTGGCATCCATCAATGCATGGGAGGCACAGAAAAGGCCAGACGTGAA
CGTATTCACACGAAGAAAGGGAACTTCAACCGACCTCTAATATCCAATCTGAAGGATGTA
GATGATTTAGCAACCCTAGAAATTTTGGATGAGAATACAGTCTCAGAGCAACTTGAGAAG
TGTTATTCCAGAGATCAGATCTACGTCTATGTGGGAGACATACTCATTGCTCTTAACCCT
TTTCAGAGTCTGGGTCTTTACTCCACAAAGCATTCCAAACTATATATTGGATCAAAGAGA
ACTGCCAGTCCTCCTCACATTTTTGCAATGGCTGACTTAGGATATCAATCTATAATAACA
TATAATTCAGATCAGTGCATTGTTATTTCTGGAGAAAGTGGTGCTGGAAAGACTGAAAAT
GCTCATCTTTTAGTTCAGCAGCTGACAGTGCTTGGAAAGGCTAATAACAGAACCTTGCAA
GAGAAGATTTTACAAGTGAACAATTTGGTAGAAGCCTTTGGCAATGCCTGCACTATTATA
AATGACAATTCTAGCAGATTTGGAAAATACTTAGAAATGAAATTCACCTCTTCTGGAGCG
GTAGTGGGAGCACAGATTTCTGAATATCTCCTGGAAAAATCCCGAGTTATCCACCAAGCT
ATTGGAGAAAAAAATTTTCATATTTTTTACTACATTTATGCTGGTTTGGCTGAAAAGAAG
AAACTAGCCCATTACAAACTGCCTGAAAATAAGCCTCCCAGGTACCTACAAAATGACCAC
CTCAGAACAGTACAAGACATCATGAATAATAGTTTCTATAAATCCCAGTATGAATTAATT
GAGCAATGTTTCAAAGTCATAGGTTTTACAATGGAGCAACTTGGTAGTATATACAGCATA
CTCGCTGCAATCTTGAATGTTGGCAACATTGAATTTTCTTCTGTGGCAACTGAACACCAG
ATTGACAAGAGCCACATTTCTAATCATACAGCCCTGGAGAACTGTGTTTCTTTGCTTTGC
ATTCGGGCAGATGAGCTACAAGAAGCTCTCACCTCCCACTGTGTGGTCACTAGAGGAGAA
ACAATTATACGACCCAATACTGTAGAAAAAGCTACCGATGTCAGGGATGCCATGGCTAAA
ACTTTATATGGACGTCTCTTTAGTTGGATAGTCAATTGCATTAACAGTTTGTTGAAGCAT
GACTCATCACCAAGTGGGAATGGTGATGAGCTGAGCATTGGCATTCTTGATATATTTGGT
TTTGAAAATTTCAAAAAAAATTCCTTCGAGCAGCTGTGCATTAACATTGCAAATGAACAA
ATTCAGTATTATTATAATCAACATGTGTTTGCATGGGAACAGAATGAATACCTAAATGAA
GATGTGGATGCTAGAGTTATTGAATATGAGGATAACTGGCCCCTCTTAGATATGTTTCTG
CAAAAGCCAATGGGTTTACTTTCCCTACTTGATGAAGAAAGTAGATTTCCCAAGGCCACT
GACCAGACTCTTGTAGAAAAATTTGAAGGTAACCTGAAATCACAATACTTCTGGAGACCC
AAAAGAATGGAACTTAGTTTTGGAATTCACCATTATGCAGGAAAGGTCCTCTATAATGCA
AGTGGATTCTTAGCCAAAAACAAGACACTAGTTCCTACTGACATTGTGCTACTTTTGAGG
TCATCCGACAACAGTGTAATTAGGCAACTAGTCAACCACCCTCTGACCAAAACAGGTAAT
CTGCCACATTCTAAACTAAAAATGTTAAACTATCAAATGAGGACTTCAGAAAAATTAATC
AACCTGGCAAAGGGCGACACTGGAGAAGCCACACGTCATGCCAGAGAGACAACCAACATG
AAAACACAAACGGTTGCATCATATTTTAGATATTCCCTGATGGATTTGTTGTCTAAAATG
GTGGTGGGCCAACCTCATTTTGTCCGTTGCATCAAACCAAATAGTGAGCGTCAGGCAAGA
AAATATGACAAAGAGAAAGTTCTGCTACAGCTTCGGTACACAGGAATTCTGGAAACAGCA
AGAATTCGAAGACTAGGATTCTCCCATCGGATACTTTTTGCTAACTTTATAAAGCGGTAC
TACCTTCTCTGCTACAAGTCGAGCGAGGAGCCCCGCATGAGCCCTGACACCTGTGCCACC
ATTTTGGAAAAAGCTGGTCTCGATAACTGGGCTCTTGGAAAAACAAAAGTGTTCCTTAAG
TATTATCACGTGGAGCAGTTAAATCTAATGCGAAAGGAAGCTATTGACAAGCTTATTTTG
ATTCAAGCTTGTGTCAGAGCATTCTTGTGTTCAAGAAGATACCAAAAAATACAGGAGAAA
AGGAAAGAAAGCGCTATAATAATACAGTCAGCTGCAAGAGGACACCTTGTCGGGAAACAA
AGAAAAGAAATTGTTGACATGAAAAACACAGCAGTAACAACCATTCAAACTTCTGATCAG
GAATTCGACTACAAGAAAAACTTTGAAAATACAAGGGAATCTTTCGTGAAGAAACAAGCA
GAAAATGCAATCTCTGCTAATGAAAGATTCATTTCAGCTCCAAATAATAAAGGAAGTGTA
TCTGTAGTGAAGACTTCCACTTTCAAACCTGAAGAGGAAACCACCAATGCTGTGGAGAGT
AACAACAGAGTGTATCAGACTCCAAAAAAAATGAATAATGTGTATGAGGAAGAGGTTAAG
CAAGAATTTTACCTTGTAGGGCCAGAAGTAAGCCCCAAACAGAAGTTTGTCAAAGACCTG
GAAGAGAACAGCAATCTAAGGAAAGTGGAGAAAGAGGAAGCTATGATCCAGAGTTACTAT
CAGAGGTACACAGAGGAGAGGAATTGTGAAGAGTCAAAAGCAGCATATCTAGAAAGGAAG
GCCATATCAGAAAGGCCAAGCTACCCAGTGCCTTGGTTAGCTGAAAATGAGACTTCCTTT
AAAAAAACTTTGGAACCTACACTTAGCCAAAGGTCAATTTATCAAAATGCAAACAGCATG
GAAAAAGAAAAGAAGACATCTGTAGTTACCCAGAGTGCACCGATATGCAGCCAGGAGGAA
GGCAGAGGCCGTCTGAGGCATGAGACAGTCAAAGAGAGGCAAGTTGAACCAGTGACACAG
GCCCAGGAGGAAGAAGATAAAGCAGCGGTATTCATTCAGAGCAAATACCGGGGTTACAAG
AGAAGGCAGCAGTTGAGGAAGGACAAGATGTCTTCTTTTAAGCATCAGAAGATTGTCACA
ACACCAACAGAAGTAGCAAGAAACACTCATAATTTGTATTCCTATCCCACAAAACATGAG
GAAATCAATAACATCAAGAAGAAGGATAACAAAGACTCGAAAGCAACTTCAGAAAGAGAA
GCATGTGGTTTGGCAATTTTTTCAAAACAGATATCAAAGTTATCTGAAGAATATTTCATT
CTGCAGAAAAAATTGAATGAAATGATTTTGTCACAGCAACTGAAGTCACTTTATCTGGGT
GTCTCGCACCATAAGCCAATTAATAGACGAGTTTCTTCTCAGCAGTGCCTCTCAGGTGTC
TGTAAAGGAGAGGAGCCAAAAATATTGAGACCCCCAAGACGACCCCGGAAACCCAAAACA
TTAAATAACCCTGAAGACTCCACATACTATTATCTACTTCATAAGTCAATCCAAGAAGAA
AAACGAAGACCAAGGAAAGACAGTCAGGGAAAATTATTAGATTTGGAAGATTTCTATTAT
AAGGAATTTTTGCCCAGTCGTTCTGGACCAAAGGAACATAGCCCTAGTTTAAGAGAACGA
AGACCACAGCAAGAACTCCAGAATCAATGTATTAAGGCTAATGAAAGGTGCTGGGCGGCG
GAGAGCCCCGAGAAGGAGGAGGAGAGAGAGCCAGCAGCCAACCCCTACGACTTCAGGAGG
CTCCTGCGCAAAACCTCCCAGCGCCGGCGCCTCGTCCAGCAGTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1616 |
| Molecular Weight
| 186207.0 |
| Theoretical pI
| 9.25 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Myosin-IIIa
MFPLIGKTIIFDNFPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDE
EIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGE
RMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRH
RRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALF
KIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQ
LTEFIGIHQCMGGTEKARRERIHTKKGNFNRPLISNLKDVDDLATLEILDENTVSEQLEK
CYSRDQIYVYVGDILIALNPFQSLGLYSTKHSKLYIGSKRTASPPHIFAMADLGYQSMIT
YNSDQCIVISGESGAGKTENAHLLVQQLTVLGKANNRTLQEKILQVNNLVEAFGNACTII
NDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHIFYYIYAGLAEKK
KLAHYKLPENKPPRYLQNDHLRTVQDIMNNSFYKSQYELIEQCFKVIGFTMEQLGSIYSI
LAAILNVGNIEFSSVATEHQIDKSHISNHTALENCASLLCIRADELQEALTSHCVVTRGE
TIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCINSLLKHDSSPSGNGDELSIGILDIFG
FENFKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNEDVDARVIEYEDNWPLLDMFL
QKPMGLLSLLDEESRFPKATDQTLVEKFEGNLKSQYFWRPKRMELSFGIHHYAGKVLYNA
SGFLAKNRDTLPTDIVLLLRSSDNSVIRQLVNHPLTKTGNLPHSKTKNVINYQMRTSEKL
INLAKGDTGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNSERQA
RKYDKEKVLLQLRYTGILETARIRRLGFSHRILFANFIKRYYLLCYKSSEEPRMSPDTCA
TILEKAGLDNWALGKTKVFLKYYHVEQLNLMRKEAIDKLILIQACVRAFLCSRRYQKIQE
KRKESAIIIQSAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENTRESFVKKQ
AENAISANERFISAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQTPKKMNNVYEEEV
KQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAAYLER
KAISERPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAPICSQE
EGRGRLRHETVKERQVEPVTQAQEEEDKAAVFIQSKYRGYKRRQQLRKDKMSSFKHQRIV
TTPTEVARNTHNLYSYPTKHEEINNIKKKDNKDSKATSEREACGLAIFSKQISKLSEEYF
ILQKKLNEMILSQQLKSLYLGVSHHKPINRRVSSQQCLSGVCKGEEPKILRPPRRPRKPK
TLNNPEDSTYYYLLHKSIQEEKRRPRKDSQGKLLDLEDFYYKEFLPSRSGPKEHSPSLRE
RRPQQELQNQCIKANERCWAAESPEKEEEREPAANPYDFRRLLRKTSQRRRLVQQS
|
| External Links |
|---|
| GenBank ID Protein
| 7958618 |
| UniProtKB/Swiss-Prot ID
| Q8NEV4 |
| UniProtKB/Swiss-Prot Entry Name
| MYO3A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF229172 |
| GeneCard ID
| MYO3A |
| GenAtlas ID
| MYO3A |
| HGNC ID
| HGNC:7601 |
| References |
|---|
| General References
| Not Available |