| Identification |
|---|
| HMDB Protein ID
| CDBP01032 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA pseudouridine synthase A, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- tRNA pseudouridylate synthase I
- tRNA-uridine isomerase I
|
| Gene Name
| PUS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in RNA binding |
| Specific Function
| Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| nucleic acid binding |
| isomerase activity |
| pseudouridine synthase activity |
| intramolecular transferase activity |
| rna binding |
| Process |
| rna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna modification |
| pseudouridine synthesis |
|
| Cellular Location
|
- Isoform 2:Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q24.33 |
| SNPs
| PUS1 |
| Gene Sequence
|
>1284 bp
ATGGGCCTCCAGCTTCGCGCGCTGTTGGGAGCCTTCGGACGGTGGACCCTGCGCCTGGGA
CCGCGTCCGTCCTGCTCGCCGCGCATGGCCGGGAACGCGGAGCCGCCGCCCGCCGGAGCC
GCATGCCCCCAGGACCGGAGGTCCTGCAGCGGCCGGGCCGGGGGCGACCGCGTCTGGGAG
GACGGAGAACATCCGGCGAAGAAGCTCAAGAGCGGTGGCGACGAGGAGCGGCGCGAGAAG
CCGCCCAAGCGGAAGATCGTGCTGCTCATGGCCTATTCGGGCAAGGGCTACCACGGCATG
CAGAGGAATGTCGGGTCCTCACAATTCAAAACAATTGAAGATGACTTGGTGTCCGCCCTC
GTCCGGTCAGGCTGTATTCCTGAAAATCATGGTGAGGACATGAGGAAAATGTCCTTCCAG
CGCTGCGCCCGGACAGACAAGGGTGTGTCCGCAGCCGGCCAGGTGGTATCCCTGAAGGTG
TGGCTGATTGACGACATTCTAGAAAAGATCAACAGCCACCTTCCCTCTCACATTCGGATT
CTGGGACTGAAGCGGGTCACGGGCGGGTTTAACTCCAAGAACAGATGTGATGCCAGGACC
TATTGCTACCTGCTGCCCACGTTTGCCTTTGCGCACAAGGACCGGGACGTTCAGGATGAG
ACCTACCGCCTGAGCGCCGAGACGCTGCAGCAGGTCAACAGGCTCCTGGCCTGCTACAAG
GGCACGCACAACTTCCACAATTTCACCTCGCAGAAGGGGCCGCAGGATCCCAGTGCCTGC
CGCTACATCCTGGAGATGTACTGCGAGGAACCCTTTGTGCGGGAGGGCCTGGAGTTTGCG
GTGATCAGGGTGAAGGGCCAGAGCTTCATGATGCATCAGATCCGGAAGATGGTCGGCCTG
GTGGTGGCCATTGTGAAGGGTTATGCCCCTGAGAGCGTGCTGGAGCGCAGCTGGGGCACA
GAGAAGGTGGACGTGCCCAAGGCGCCCGGACTCGGCCTGGTCCTGGAGAGGGTGCACTTC
GAGAAGTACAACCAGCGCTTTGGCAACGATGGGCTGCATGAGCCGCTGGACTGGGCGCAG
GAGGAAGGAAAGGTCGCAGCCTTCAAGGAGGAGCACATCTACCCCACCATCATCGGCACC
GAGCGGGACGAACGCTCCATGGCCCAGTGGCTGAGCACCTTGCCCATCCACAACTTCAGT
GCCACCGCTCTCACGGCAGGTGGCACGGGCGCCAAGGTGCCCAGTCCCCTGGAAGGCAGT
GAAGGGGACGGAGACACTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 427 |
| Molecular Weight
| 47469.7 |
| Theoretical pI
| 8.54 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>tRNA pseudouridine synthase A, mitochondrial
MGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWE
DGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSAL
VRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRI
LGLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYK
GTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGL
VVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQ
EEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGS
EGDGDTD
|
| External Links |
|---|
| GenBank ID Protein
| 70166645 |
| UniProtKB/Swiss-Prot ID
| Q9Y606 |
| UniProtKB/Swiss-Prot Entry Name
| TRUA_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_025215.5 |
| GeneCard ID
| PUS1 |
| GenAtlas ID
| PUS1 |
| HGNC ID
| HGNC:15508 |
| References |
|---|
| General References
| Not Available |