Cannabis Compound Database: Showing Protein Type II iodothyronine deiodinase (CDBP00999)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00999

Secondary Accession Numbers

Not Available

Name

Type II iodothyronine deiodinase

Description

Not Available

Synonyms

5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase

Gene Name

DIO2

Protein Type

Enzyme

Biological Properties

General Function

Involved in thyroxine 5'-deiodinase activity

Specific Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.

GO Classification

Biological Process
selenocysteine incorporation
hormone biosynthetic process
thyroid hormone generation
cellular nitrogen compound metabolic process
Cellular Component
plasma membrane
integral to membrane
Function
catalytic activity
thyroxine 5'-deiodinase activity
oxidoreductase activity
Molecular Function
selenium binding
thyroxine 5'-deiodinase activity
Process
metabolic process
oxidation reduction

Cellular Location

Membrane
Single-pass membrane protein (Potential)

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

14q24.2-q24.3

SNPs

DIO2

Gene Sequence

>822 bp
ATGGGCATCCTCAGCGTAGACTTGCTGATCACACTGCAAATTCTGCCAGTTTTTTTCTCC
AACTGCCTCTTCCTGGCTCTCTATGACTCGGTCATTCTGCTCAAGCACGTGGTGCTGCTG
TTGAGCCGCTCCAAGTCCACTCGCGGAGAGTGGCGGCGCATGCTGACCTCAGAGGGACTG
CGCTGCGTCTGGAAGAGCTTCCTCCTCGATGCCTACAAACAGGTGAAATTGGGTGAGGAT
GCCCCCAATTCCAGTGTGGTGCATGTCTCCAGTACAGAAGGAGGTGACAACAGTGGCAAT
GGTACCCAGGAGAAGATAGCTGAGGGAGCCACATGCCACCTTCTTGACTTTGCCAGCCCT
GAGCGCCCACTAGTGGTCAACTTTGGCTCAGCCACTTGACCTCCTTTCACGAGCCAGCTG
CCAGCCTTCCGCAAACTGGTGGAAGAGTTCTCCTCAGTGGCTGACTTCCTGCTGGTCTAC
ATTGATGAGGCTCATCCATCAGATGGCTGGGCGATACCGGGGGACTCCTCTTTGTCTTTT
GAGGTGAAGAAGCACCAGAACCAGGAAGATCGATGTGCAGCAGCCCAGCAGCTTCTGGAG
CGTTTCTCCTTGCCGCCCCAGTGCCGAGTTGTGGCTGACCGCATGGACAATAACGCCAAC
ATAGCTTACGGGGTAGCCTTTGAACGTGTGTGCATTGTGCAGAGACAGAAAATTGCTTAT
CTGGGAGGAAAGGGCCCCTTCTCCTACAACCTTCAAGAAGTCCGGCATTGGCTGGAGAAG
AATTTCAGCAAGAGATGAAAGAAAACTAGATTAGCTGGTTAA

Protein Properties

Number of Residues

273

Molecular Weight

30551.48

Theoretical pI

8.01

Pfam Domain Function

T4_deiodinase (PF00837 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Type II iodothyronine deiodinase
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q92813

UniProtKB/Swiss-Prot Entry Name

IOD2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

U53506

GeneCard ID