Identification
HMDB Protein ID CDBP00999
Secondary Accession Numbers Not Available
Name Type II iodothyronine deiodinase
Description Not Available
Synonyms
  1. 5DII
  2. DIOII
  3. Type 2 DI
  4. Type-II 5'-deiodinase
Gene Name DIO2
Protein Type Enzyme
Biological Properties
General Function Involved in thyroxine 5'-deiodinase activity
Specific Function Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
GO Classification
Biological Process
selenocysteine incorporation
hormone biosynthetic process
thyroid hormone generation
cellular nitrogen compound metabolic process
Cellular Component
plasma membrane
integral to membrane
Function
catalytic activity
thyroxine 5'-deiodinase activity
oxidoreductase activity
Molecular Function
selenium binding
thyroxine 5'-deiodinase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Membrane
  2. Single-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location 14
Locus 14q24.2-q24.3
SNPs DIO2
Gene Sequence
>822 bp
ATGGGCATCCTCAGCGTAGACTTGCTGATCACACTGCAAATTCTGCCAGTTTTTTTCTCC
AACTGCCTCTTCCTGGCTCTCTATGACTCGGTCATTCTGCTCAAGCACGTGGTGCTGCTG
TTGAGCCGCTCCAAGTCCACTCGCGGAGAGTGGCGGCGCATGCTGACCTCAGAGGGACTG
CGCTGCGTCTGGAAGAGCTTCCTCCTCGATGCCTACAAACAGGTGAAATTGGGTGAGGAT
GCCCCCAATTCCAGTGTGGTGCATGTCTCCAGTACAGAAGGAGGTGACAACAGTGGCAAT
GGTACCCAGGAGAAGATAGCTGAGGGAGCCACATGCCACCTTCTTGACTTTGCCAGCCCT
GAGCGCCCACTAGTGGTCAACTTTGGCTCAGCCACTTGACCTCCTTTCACGAGCCAGCTG
CCAGCCTTCCGCAAACTGGTGGAAGAGTTCTCCTCAGTGGCTGACTTCCTGCTGGTCTAC
ATTGATGAGGCTCATCCATCAGATGGCTGGGCGATACCGGGGGACTCCTCTTTGTCTTTT
GAGGTGAAGAAGCACCAGAACCAGGAAGATCGATGTGCAGCAGCCCAGCAGCTTCTGGAG
CGTTTCTCCTTGCCGCCCCAGTGCCGAGTTGTGGCTGACCGCATGGACAATAACGCCAAC
ATAGCTTACGGGGTAGCCTTTGAACGTGTGTGCATTGTGCAGAGACAGAAAATTGCTTAT
CTGGGAGGAAAGGGCCCCTTCTCCTACAACCTTCAAGAAGTCCGGCATTGGCTGGAGAAG
AATTTCAGCAAGAGATGAAAGAAAACTAGATTAGCTGGTTAA
Protein Properties
Number of Residues 273
Molecular Weight 30551.48
Theoretical pI 8.01
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Type II iodothyronine deiodinase
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q92813
UniProtKB/Swiss-Prot Entry Name IOD2_HUMAN
PDB IDs Not Available
GenBank Gene ID U53506
GeneCard ID DIO2
GenAtlas ID DIO2
HGNC ID HGNC:2884
References
General References Not Available