| Identification |
|---|
| HMDB Protein ID
| CDBP00998 |
| Secondary Accession Numbers
| Not Available |
| Name
| Type I iodothyronine deiodinase |
| Description
| Not Available |
| Synonyms
|
- 5DI
- DIOI
- Type 1 DI
- Type-I 5'-deiodinase
|
| Gene Name
| DIO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thyroxine 5'-deiodinase activity |
| Specific Function
| Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
|
| GO Classification
|
| Biological Process |
| cellular nitrogen compound metabolic process |
| hormone biosynthetic process |
| thyroid hormone generation |
| Cellular Component |
| endoplasmic reticulum membrane |
| plasma membrane |
| integral to membrane |
| Function |
| catalytic activity |
| thyroxine 5'-deiodinase activity |
| oxidoreductase activity |
| Molecular Function |
| selenium binding |
| thyroxine 5'-deiodinase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p33-p32 |
| SNPs
| DIO1 |
| Gene Sequence
|
>750 bp
ATGGGGCTGCCCCAGCCAGGGCTGTGGCTGAAGAGGCTCTGGGTGCTCTTGGAGGTGGCT
GTGCATGTGGTCGTGGGTAAAGTGCTTCTGATATTGTTTCCAGACAGAGTCAAGCGGAAC
ATCCTGGCCATGGGCGAGAAGACGGGTATGACCAGGAACCCCCATTTCAGCCACGACAAC
TGGATACCAACCTTTTTCAGCACCCAGTATTTCTGGTTCGTCTTGAAGGTCCGTTGGCAG
CGACTAGAGGACACGACTGAGCTAGGGGGTCTGGCCCCAAACTGCCCGGTGGTCCGCCTC
TCAGGACAGAGGTGCAACATTTGGGAGTTTATGCAAGGTAATAGGCCACTGGTGCTGAAT
TTTGGAAGTTGTACCTGACCTTCATTTATGTTCAAATTTGACCAGTTCAAGAGGCTTATT
GAAGACTTTAGTTCCATAGCAGATTTTCTTGTCATTTACATTGAAGAAGCACATGCATCA
GATGGCTGGGCTTTTAAGAACAACATGGACATCAGAAATCACCAGAACCTTCAGGATCGC
CTGCAGGCAGCCCATCTACTGCTGGCCAGGAGCCCCCAGTGCCCTGTGGTGGTGGACACC
ATGCAGAACCAGAGCAGCCAGCTCTACGCAGCACTGCCTGAGAGGCTCTACATAATCCAG
GAGGGCAGGATCCTCTACAAGGGTAAATCTGGCCCTTGGAACTACAACCCAGAGGAAGTT
CGTGCTGTTCTGGAAAAGCTCCACAGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 249 |
| Molecular Weight
| 28924.21 |
| Theoretical pI
| 8.686 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Type I iodothyronine deiodinase
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
RAVLEKLHS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P49895 |
| UniProtKB/Swiss-Prot Entry Name
| IOD1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| S48220 |
| GeneCard ID
| DIO1 |
| GenAtlas ID
| DIO1 |
| HGNC ID
| HGNC:2883 |
| References |
|---|
| General References
| Not Available |