Cannabis Compound Database: Showing Protein Mevalonate kinase (CDBP00990)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00990

Secondary Accession Numbers

Not Available

Name

Mevalonate kinase

Description

Not Available

Synonyms

Gene Name

MVK

Protein Type

Enzyme

Biological Properties

General Function

Involved in ATP binding

Specific Function

May be a regulatory site in cholesterol biosynthetic pathway.

GO Classification

Biological Process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isoprenoid biosynthetic process
negative regulation of inflammatory response
cholesterol biosynthetic process
Cellular Component
cytosol
Component
cell part
intracellular part
cytoplasm
Function
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
phosphotransferase activity, alcohol group as acceptor
mevalonate kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
Molecular Function
mevalonate kinase activity
ATP binding
Process
isoprenoid metabolic process
isoprenoid biosynthetic process
phosphorylation
phosphorus metabolic process
phosphate metabolic process
metabolic process
primary metabolic process
cellular metabolic process
lipid metabolic process
cellular lipid metabolic process

Cellular Location

Cytoplasm
Peroxisome

Pathways

Name	SMPDB/Pathwhiz	KEGG
isopentenyl diphosphate biosynthesis via mevalonate pathway	Not Available	Not Available
Terpenoid backbone biosynthesis	Not Available
Peroxisome	Not Available
Steroid Biosynthesis
Smith-Lemli-Opitz Syndrome (SLOS)		Not Available

Gene Properties

Chromosome Location

Locus

12q24

SNPs

MVK

Gene Sequence

>1191 bp
ATGTTGTCAGAAGTCCTACTGGTGTCTGCTCCGGGGAAAGTCATCCTTCATGGAGAACAT
GCCGTGGTACATGGCAAGGTAGCACTGGCTGTATCCTTGAACTTGAGAACATTCCTCCGG
CTTCAACCCCACAGCAATGGGAAAGTGGACCTCAGCTTACCCAACATTGGTATCAAGCGG
GCCTGGGATGTGGCCAGGCTTCAGTCACTGGACACAAGCTTTCTGGAGCAAGGTGATGTC
ACAACACCCACCTCAGAGCAAGTGGAGAAGCTAAAGGAGGTTGCAGGCTTGCCTGACGAC
TGTGCTGTCACCGAGCGCCTGGCTGTGCTGGCCTTTCTTTACTTATACCTGTCCATCTGC
CGGAAGCAGAGGGCCCTGCCGAGCCTGGATATCGTAGTGTGGTCGGAGCTGCCCCCCGGG
GCGGGCTTGGGCTCCAGCGCCGCCTACTCGGTGTGTCTGGCAGCAGCCCTCCTGACTGTG
TGCGAGGAGATCCCAAACCCGCTGAAGGACGGGGATTGCGTCAACAGGTGGACCAAGGAG
GATTTGGAGCTAATTAACAAGTGGGCCTTCCAAGGGGAGAGAATGATTCACGGGAACCCC
TCCGGAGTGGACAATGCTGTCAGCACCTGGGGAGGAGCCCTCCGATACCATCAAGGGAAG
ATTTCATCCTTAAAGAGGTCGCCAGCTCTCCAGATCCTGCTGACCAACACCAAAGTCCCT
CGCAATACCAGGGCCCTTGTGGCTGGCGTCAGAAACAGGCTGCTCAAGTTCCCAGAGATC
GTGGCCCCCCTCCTGACCTCAATAGATGCCATCTCCCTGGAGTGTGAGCGCGTGCTGGGA
GAGATGGGGGAAGCCCCAGCCCCGGAGCAGTACCTCGTGCTGGAAGAGCTCATTGACATG
AACCAGCACCATCTGAATGCCCTCGGCGTGGGCCACGCCTCTCTGGACCAGCTCTGCCAG
GTGACCAGGGCCCGCGGACTTCACAGCAAGCTGACTGGCGCAGGCGGTGGTGGCTGTGGC
ATCACACTCCTCAAGCCAGGGCTGGAGCAGCCAGAAGTGGAGGCCACGAAGCAGGCCCTG
ACCAGCTGTGGCTTTGACTGCTTGGAAACCAGCATCGGTGCCCCCGGCGTCTCCATCCAC
TCAGCCACCTCCCTGGACAGCCGAGTCCAGCAAGCCCTGGATGGCCTCTGA

Protein Properties

Number of Residues

396

Molecular Weight

42450.475

Theoretical pI

6.459

Pfam Domain Function

GHMP_kinases_C (PF08544 )
GHMP_kinases_N (PF00288 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Mevalonate kinase
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR
AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC
RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE
DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP
RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM
NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL
TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q03426

UniProtKB/Swiss-Prot Entry Name

KIME_HUMAN

PDB IDs