Identification
HMDB Protein ID CDBP00988
Secondary Accession Numbers Not Available
Name Lysosomal thioesterase PPT2
Description Not Available
Synonyms
  1. PPT-2
  2. S-thioesterase G14
Gene Name PPT2
Protein Type Enzyme
Biological Properties
General Function Involved in palmitoyl-(protein) hydrolase activity
Specific Function Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.
GO Classification
Biological Process
cellular protein modification process
Cellular Component
lysosome
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
palmitoyl-(protein) hydrolase activity
thiolester hydrolase activity
Molecular Function
palmitoyl-(protein) hydrolase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
Cellular Location
  1. Lysosome
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs PPT2
Gene Sequence
>909 bp
ATGCTGGGGCTCTGGGGGCAGCGGCTCCCCGCGGCGTGGGTCCTGCTTCTGTTGCCTTTC
CTGCCGCTGCTGCTGCTTGCAGCCCCCGCGCCCCACCGCGCGTCCTACAAGCCGGTCATC
GTGGTGCATGGGCTCTTCGACAGCTCGTACAGCTTCCGCCACCTGCTGGAATACATCAAT
GAGACACACCCCGGGACTGTGGTGACAGTGCTCGATCTCTTCGATGGGAGAGAGAGCTTG
CGACCCCTGTGGGAACAGGTGCAAGGGTTCCGAGAGGCTGTGGTCCCCATCATGGCAAAG
GCCCCTCAAGGGGTGCATCTCATCTGCTACTCGCAGGGGGGCCTTGTGTGCCGGGCTCTG
CTTTCTGTCATGGATGATCACAACGTGGATTCTTTCATCTCCCTCTCCTCTCCACAGATG
GGACAGTATGGAGACACGGACTACTTGAAGTGGCTGTTCCCCACCTCCATGCGGTCTAAC
CTCTATCGGATCTGCTATAGCCCCTGGGGCCAGGAATTCTCCATCTGCAACTACTGGCAT
GATCCCCACCACGATGACTTGTACCTCAATGCCAGCAGCTTCCTGGCCCTGATCAATGGG
GAAAGAGACCATCCCAATGCCACAGTATGGCGGAAGAACTTTCTGCGTGTGGGCCACCTG
GTGCTGATTGGGGGCCCTGATGATGGTGTTATTACTCCCTGGCAGTCCAGCTTCTTTGGT
TTCTATGATGCAAATGAGACCGTCCTGGAGATGGAGGAGCAACTGGTTTATCTGCGGGAT
TCTTTTGGGTTGAAGACTCTATTGGCCCGGGGGGCCATAGTGAGGTGTCCAATGGCCGGT
ATCTCCCACACAGCCTGGCACTCCAACCGTACCCTTTATGAGACCTGCATTGAACCTTGG
CTCTCCTGA
Protein Properties
Number of Residues 302
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Lysosomal thioesterase PPT2
MLGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHRASYKPVIVVHGLFDSSYSFRHLLEYIN
ETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRAL
LSVMDDHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWH
DPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRVGHLVLIGGPDDGVITPWQSSFFG
FYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPW
LS
GenBank ID Protein 2501961
UniProtKB/Swiss-Prot ID Q9UMR5
UniProtKB/Swiss-Prot Entry Name PPT2_HUMAN
PDB IDs
GenBank Gene ID AF020543
GeneCard ID PPT2
GenAtlas ID PPT2
HGNC ID HGNC:9326
References
General References Not Available