| Identification |
|---|
| HMDB Protein ID
| CDBP00988 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lysosomal thioesterase PPT2 |
| Description
| Not Available |
| Synonyms
|
- PPT-2
- S-thioesterase G14
|
| Gene Name
| PPT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in palmitoyl-(protein) hydrolase activity |
| Specific Function
| Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.
|
| GO Classification
|
| Biological Process |
| cellular protein modification process |
| Cellular Component |
| lysosome |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| palmitoyl-(protein) hydrolase activity |
| thiolester hydrolase activity |
| Molecular Function |
| palmitoyl-(protein) hydrolase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
- Lysosome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fatty acid elongation | Not Available |  | | Lysosome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| PPT2 |
| Gene Sequence
|
>909 bp
ATGCTGGGGCTCTGGGGGCAGCGGCTCCCCGCGGCGTGGGTCCTGCTTCTGTTGCCTTTC
CTGCCGCTGCTGCTGCTTGCAGCCCCCGCGCCCCACCGCGCGTCCTACAAGCCGGTCATC
GTGGTGCATGGGCTCTTCGACAGCTCGTACAGCTTCCGCCACCTGCTGGAATACATCAAT
GAGACACACCCCGGGACTGTGGTGACAGTGCTCGATCTCTTCGATGGGAGAGAGAGCTTG
CGACCCCTGTGGGAACAGGTGCAAGGGTTCCGAGAGGCTGTGGTCCCCATCATGGCAAAG
GCCCCTCAAGGGGTGCATCTCATCTGCTACTCGCAGGGGGGCCTTGTGTGCCGGGCTCTG
CTTTCTGTCATGGATGATCACAACGTGGATTCTTTCATCTCCCTCTCCTCTCCACAGATG
GGACAGTATGGAGACACGGACTACTTGAAGTGGCTGTTCCCCACCTCCATGCGGTCTAAC
CTCTATCGGATCTGCTATAGCCCCTGGGGCCAGGAATTCTCCATCTGCAACTACTGGCAT
GATCCCCACCACGATGACTTGTACCTCAATGCCAGCAGCTTCCTGGCCCTGATCAATGGG
GAAAGAGACCATCCCAATGCCACAGTATGGCGGAAGAACTTTCTGCGTGTGGGCCACCTG
GTGCTGATTGGGGGCCCTGATGATGGTGTTATTACTCCCTGGCAGTCCAGCTTCTTTGGT
TTCTATGATGCAAATGAGACCGTCCTGGAGATGGAGGAGCAACTGGTTTATCTGCGGGAT
TCTTTTGGGTTGAAGACTCTATTGGCCCGGGGGGCCATAGTGAGGTGTCCAATGGCCGGT
ATCTCCCACACAGCCTGGCACTCCAACCGTACCCTTTATGAGACCTGCATTGAACCTTGG
CTCTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 302 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lysosomal thioesterase PPT2
MLGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHRASYKPVIVVHGLFDSSYSFRHLLEYIN
ETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRAL
LSVMDDHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWH
DPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRVGHLVLIGGPDDGVITPWQSSFFG
FYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPW
LS
|
| External Links |
|---|
| GenBank ID Protein
| 2501961 |
| UniProtKB/Swiss-Prot ID
| Q9UMR5 |
| UniProtKB/Swiss-Prot Entry Name
| PPT2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF020543 |
| GeneCard ID
| PPT2 |
| GenAtlas ID
| PPT2 |
| HGNC ID
| HGNC:9326 |
| References |
|---|
| General References
| Not Available |