Cannabis Compound Database: Showing Protein Palmitoyl-protein thioesterase 1 (CDBP00987)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00987

Secondary Accession Numbers

Not Available

Name

Palmitoyl-protein thioesterase 1

Description

Not Available

Synonyms

PPT-1
Palmitoyl-protein hydrolase 1

Gene Name

PPT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in palmitoyl-(protein) hydrolase activity

Specific Function

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.

GO Classification

Biological Process
regulation of phospholipase A2 activity
sphingolipid catabolic process
negative regulation of neuron apoptotic process
protein transport
regulation of synapse structure and activity
adult locomotory behavior
apoptotic DNA fragmentation
positive regulation of receptor-mediated endocytosis
associative learning
brain development
cellular protein catabolic process
negative regulation of cell growth
cofactor metabolic process
visual perception
cofactor transport
neurotransmitter secretion
lysosomal lumen acidification
grooming behavior
membrane raft organization
receptor-mediated endocytosis
neuron development
pinocytosis
positive regulation of pinocytosis
protein depalmitoylation
Cellular Component
Golgi apparatus
nucleus
synaptic vesicle
lysosome
extracellular region
neuronal cell body
extracellular space
axon
cytosol
membrane raft
dendrite
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
palmitoyl-(protein) hydrolase activity
thiolester hydrolase activity
Molecular Function
palmitoyl-CoA hydrolase activity
palmitoyl-(protein) hydrolase activity
Process
macromolecule metabolic process
macromolecule modification
protein modification process
metabolic process

Cellular Location

Lysosome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Fatty Acid Elongation In Mitochondria
Fatty acid elongation	Not Available
Lysosome	Not Available
Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD)		Not Available

Gene Properties

Chromosome Location

Locus

1p32

SNPs

PPT1

Gene Sequence

>921 bp
ATGGCGTCGCCCGGCTGCCTGTGGCTCTTGGCTGTGGCTCTCCTGCCATGGACCTGCGCT
TCTCGGGCGCTGCAGCATCTGGACCCGCCGGCGCCGCTGCCGTTGGTGATCTGGCATGGG
ATGGGAGACAGCTGTTGCAATCCCTTAAGCATGGGTGCTATTAAAAAAATGGTGGAGAAG
AAAATACCTGGAATTTACGTCTTATCTTTAGAGATTGGGAAGACCCTGATGGAGGACGTG
GAGAACAGCTTCTTCTTGAATGTCAATTCCCAAGTAACAACAGTGTGTCAGGCACTTGCT
AAGGATCCTAAATTGCAGCAAGGCTACAATGCTATGGGATTCTCCCAGGGAGGCCAATTT
CTGAGGGCAGTGGCTCAGAGATGCCCTTCACCTCCCATGATCAATCTGATCTCGGTTGGG
GGACAACATCAAGGTGTTTTTGGACTCCCTCGATGCCCAGGAGAGAGCTCTCACATCTGT
GACTTCATCCGAAAAACACTGAATGCTGGGGCGTACTCCAAAGTTGTTCAGGAACGCCTC
GTGCAAGCCGAATACTGGCATGACCCCATAAAGGAGGATGTGTATCGCAACCACAGCATC
TTCTTGGCAGATATAAATCAGGAGCGGGGTATCAATGAGTCCTACAAGAAAAACCTGATG
GCCCTGAAGAAGTTTGTGATGGTGAAATTCCTCAATGATTCCATTGTGGACCCTGTAGAT
TCGGAGTGGTTTGGATTTTACAGAAGTGGCCAAGCCAAGGAAACCATTCCCTTACAGGAG
ACCTCCCTGTACACACAGGACCGCCTGGGGCTAAAGGAAATGGACAATGCAGGACAGCTA
GTGTTTCTGGCTACAGAAGGGGACCATCTTCAGTTGTCTGAAGAATGGTTTTATGCCCAC
ATCATACCATTCCTTGGATGA

Protein Properties

Number of Residues

306

Molecular Weight

34193.245

Theoretical pI

6.523

Pfam Domain Function

Palm_thioest (PF02089 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Palmitoyl-protein thioesterase 1
MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
IIPFLG

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P50897

UniProtKB/Swiss-Prot Entry Name

PPT1_HUMAN

PDB IDs