Identification
HMDB Protein ID CDBP00987
Secondary Accession Numbers Not Available
Name Palmitoyl-protein thioesterase 1
Description Not Available
Synonyms
  1. PPT-1
  2. Palmitoyl-protein hydrolase 1
Gene Name PPT1
Protein Type Enzyme
Biological Properties
General Function Involved in palmitoyl-(protein) hydrolase activity
Specific Function Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
GO Classification
Biological Process
regulation of phospholipase A2 activity
sphingolipid catabolic process
negative regulation of neuron apoptotic process
protein transport
regulation of synapse structure and activity
adult locomotory behavior
apoptotic DNA fragmentation
positive regulation of receptor-mediated endocytosis
associative learning
brain development
cellular protein catabolic process
negative regulation of cell growth
cofactor metabolic process
visual perception
cofactor transport
neurotransmitter secretion
lysosomal lumen acidification
grooming behavior
membrane raft organization
receptor-mediated endocytosis
neuron development
pinocytosis
positive regulation of pinocytosis
protein depalmitoylation
Cellular Component
Golgi apparatus
nucleus
synaptic vesicle
lysosome
extracellular region
neuronal cell body
extracellular space
axon
cytosol
membrane raft
dendrite
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
palmitoyl-(protein) hydrolase activity
thiolester hydrolase activity
Molecular Function
palmitoyl-CoA hydrolase activity
palmitoyl-(protein) hydrolase activity
Process
macromolecule metabolic process
macromolecule modification
protein modification process
metabolic process
Cellular Location
  1. Lysosome
Pathways
Gene Properties
Chromosome Location 1
Locus 1p32
SNPs PPT1
Gene Sequence
>921 bp
ATGGCGTCGCCCGGCTGCCTGTGGCTCTTGGCTGTGGCTCTCCTGCCATGGACCTGCGCT
TCTCGGGCGCTGCAGCATCTGGACCCGCCGGCGCCGCTGCCGTTGGTGATCTGGCATGGG
ATGGGAGACAGCTGTTGCAATCCCTTAAGCATGGGTGCTATTAAAAAAATGGTGGAGAAG
AAAATACCTGGAATTTACGTCTTATCTTTAGAGATTGGGAAGACCCTGATGGAGGACGTG
GAGAACAGCTTCTTCTTGAATGTCAATTCCCAAGTAACAACAGTGTGTCAGGCACTTGCT
AAGGATCCTAAATTGCAGCAAGGCTACAATGCTATGGGATTCTCCCAGGGAGGCCAATTT
CTGAGGGCAGTGGCTCAGAGATGCCCTTCACCTCCCATGATCAATCTGATCTCGGTTGGG
GGACAACATCAAGGTGTTTTTGGACTCCCTCGATGCCCAGGAGAGAGCTCTCACATCTGT
GACTTCATCCGAAAAACACTGAATGCTGGGGCGTACTCCAAAGTTGTTCAGGAACGCCTC
GTGCAAGCCGAATACTGGCATGACCCCATAAAGGAGGATGTGTATCGCAACCACAGCATC
TTCTTGGCAGATATAAATCAGGAGCGGGGTATCAATGAGTCCTACAAGAAAAACCTGATG
GCCCTGAAGAAGTTTGTGATGGTGAAATTCCTCAATGATTCCATTGTGGACCCTGTAGAT
TCGGAGTGGTTTGGATTTTACAGAAGTGGCCAAGCCAAGGAAACCATTCCCTTACAGGAG
ACCTCCCTGTACACACAGGACCGCCTGGGGCTAAAGGAAATGGACAATGCAGGACAGCTA
GTGTTTCTGGCTACAGAAGGGGACCATCTTCAGTTGTCTGAAGAATGGTTTTATGCCCAC
ATCATACCATTCCTTGGATGA
Protein Properties
Number of Residues 306
Molecular Weight 34193.245
Theoretical pI 6.523
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Palmitoyl-protein thioesterase 1
MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEK
KIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQF
LRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERL
VQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVD
SEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH
IIPFLG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P50897
UniProtKB/Swiss-Prot Entry Name PPT1_HUMAN
PDB IDs
GenBank Gene ID U44772
GeneCard ID PPT1
GenAtlas ID PPT1
HGNC ID HGNC:9325
References
General References Not Available