Identification
HMDB Protein ID CDBP00977
Secondary Accession Numbers Not Available
Name 2,4-dienoyl-CoA reductase, mitochondrial
Description Not Available
Synonyms
  1. 2,4-dienoyl-CoA reductase [NADPH]
  2. 4-enoyl-CoA reductase [NADPH]
Gene Name DECR1
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
GO Classification
Biological Process
protein homotetramerization
fatty acid beta-oxidation
Cellular Component
mitochondrial matrix
nucleus
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
2,4-dienoyl-CoA reductase (NADPH) activity
oxidoreductase activity, acting on NADH or NADPH
NADPH binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Mitochondrion
Pathways
Gene Properties
Chromosome Location 8
Locus 8q21.3
SNPs DECR1
Gene Sequence
>1008 bp
ATGAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCT
CCTCGGAGGTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAA
TCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAA
GTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCC
AGCCTAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCA
GAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGAT
CCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATATT
GTGATAAACAATGCAGCAGGGAATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCT
TGGAAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGA
AAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACTACTATCTATGCT
GAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATG
AGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCA
GGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAA
GAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTT
GCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGAC
GGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAG
CAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAA
Protein Properties
Number of Residues 335
Molecular Weight 36067.4
Theoretical pI 9.274
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>2,4-dienoyl-CoA reductase, mitochondrial
MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK
VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD
PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG
KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP
GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD
GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q16698
UniProtKB/Swiss-Prot Entry Name DECR_HUMAN
PDB IDs
GenBank Gene ID L26050
GeneCard ID DECR1
GenAtlas ID DECR1
HGNC ID HGNC:2753
References
General References Not Available