| Identification |
|---|
| HMDB Protein ID
| CDBP00966 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acidic mammalian chitinase |
| Description
| Not Available |
| Synonyms
|
- AMCase
- Lung-specific protein TSA1902
|
| Gene Name
| CHIA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chitin binding |
| Specific Function
| Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
|
| GO Classification
|
| Biological Process |
| chitin catabolic process |
| digestion |
| immune response |
| cell wall chitin metabolic process |
| polysaccharide catabolic process |
| positive regulation of chemokine secretion |
| production of molecular mediator involved in inflammatory response |
| response to acid |
| response to fungus |
| apoptotic process |
| Cellular Component |
| cytoplasm |
| extracellular space |
| Component |
| extracellular region |
| Function |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| pattern binding |
| polysaccharide binding |
| chitinase activity |
| chitin binding |
| ion binding |
| cation binding |
| binding |
| catalytic activity |
| Molecular Function |
| carbohydrate binding |
| cation binding |
| chitin binding |
| chitinase activity |
| lysozyme activity |
| Process |
| carbohydrate metabolic process |
| polysaccharide catabolic process |
| aminoglycan catabolic process |
| chitin catabolic process |
| chitin metabolic process |
| polysaccharide metabolic process |
| aminoglycan metabolic process |
| metabolic process |
| primary metabolic process |
|
| Cellular Location
|
- Isoform 3:Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amino sugar and nucleotide sugar metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CHIA |
| Gene Sequence
|
>1431 bp
ATGACAAAGCTTATTCTCCTCACAGGTCTTGTCCTTATACTGAATTTGCAGCTCGGCTCT
GCCTACCAGCTGACATGCTACTTCACCAACTGGGCCCAGTACCGGCCAGGCCTGGGGCGC
TTCATGCCTGACAACATCGACCCCTGCCTCTGTACCCACCTGATCTACGCCTTTGCTGGG
AGGCAGAACAACGAGATCACCACCATCGAATGGAATGATGTGACTCTCTACCAAGCTTTC
AATGGCCTGAAAAATAAGAACAGCCAGCTGAAAACTCTCCTGGCCATTGGAGGCTGGAAC
TTCGGGACTGCCCCTTTCACTGCCATGGTTTCTACTCCTGAGAACCGCCAGACTTTCATC
ACCTCAGTCATCAAATTCCTGCGCCAGTATGAGTTTGACGGGCTGGACTTTGACTGGGAG
TACCCTGGCTCTCGTGGGAGCCCTCCTCAGGACAAGCATCTCTTCACTGTCCTGGTGCAG
GAAATGCGTGAAGCTTTTGAGCAGGAGGCCAAGCAGATCAACAAGCCCAGGCTGATGGTC
ACTGCTGCAGTAGCTGCTGGCATCTCCAATATCCAGTCTGGCTATGAGATCCCCCAACTG
TCACAGTACCTGGACTACATCCATGTCATGACCTACGACCTCCATGGCTCCTGGGAGGGC
TACACTGGAGAGAACAGCCCCCTCTACAAATACCCGACTGACACCGGCAGCAACGCCTAC
CTCAATGTGGATTATGTCATGAACTACTGGAAGGACAATGGAGCACCAGCTGAGAAGCTC
ATCGTTGGATTCCCTACCTATGGACACAACTTCATCCTGAGCAACCCCTCCAACACTGGA
ATTGGTGCCCCCACCTCTGGTGCTGGTCCTGCTGGGCCCTATGCCAAGGAGTCTGGGATC
TGGGCTTACTACGAGATCTGTACCTTCCTGAAAAATGGAGCCACTCAGGGATGGGATGCC
CCTCAGGAAGTGCCTTATGCCTATCAGGGCAATGTGTGGGTTGGCTATGACAACATCAAG
AGCTTCGATATTAAGGCTCAATGGCTTAAGCACAACAAATTTGGAGGCGCCATGGTCTGG
GCCATTGATCTGGATGACTTCACTGGCACTTTCTGCAACCAGGGCAAGTTTCCCCTAATC
TCCACCCTGAAGAAGGCCCTCGGCCTGCAGAGTGCAAGTTGCACGGCTCCAGCTCAGCCC
ATTGAGCCAATAACTGCTGCTCCCAGTGGCAGCGGGAACGGGAGCGGGAGTAGCAGCTCT
GGAGGCAGCTCGGGAGGCAGTGGATTCTGTGCTGTCAGAGCCAACGGCCTCTACCCCGTG
GCAAATAACAGAAATGCCTTCTGGCACTGCGTGAATGGAGTCACGTACCAGCAGAACTGC
CAGGCCGGGCTTGTCTTCGACACCAGCTGTGATTGCTGCAACTGGGCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 476 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acidic mammalian chitinase
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
|
| External Links |
|---|
| GenBank ID Protein
| 133893286 |
| UniProtKB/Swiss-Prot ID
| Q9BZP6 |
| UniProtKB/Swiss-Prot Entry Name
| CHIA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_201653.2 |
| GeneCard ID
| CHIA |
| GenAtlas ID
| CHIA |
| HGNC ID
| HGNC:17432 |
| References |
|---|
| General References
| Not Available |