Identification
HMDB Protein ID CDBP00955
Secondary Accession Numbers Not Available
Name Phosphomevalonate kinase
Description Not Available
Synonyms
  1. PMKase
  2. hPMK
Gene Name PMVK
Protein Type Enzyme
Biological Properties
General Function Involved in phosphomevalonate kinase activity
Specific Function Not Available
GO Classification
Biological Process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
cholesterol biosynthetic process
response to cholesterol
Cellular Component
cytosol
peroxisome
Component
cell part
intracellular part
cytoplasm
Function
transferase activity, transferring phosphorus-containing groups
kinase activity
phosphomevalonate kinase activity
catalytic activity
transferase activity
Molecular Function
ATP binding
phosphomevalonate kinase activity
Process
sterol metabolic process
cholesterol metabolic process
metabolic process
small molecule metabolic process
alcohol metabolic process
cholesterol biosynthetic process
Cellular Location
  1. Peroxisome
Pathways
Gene Properties
Chromosome Location 1
Locus 1q22
SNPs PMVK
Gene Sequence
>579 bp
ATGGCCCCGCTGGGAGGCGCCCCGCGGCTGGTACTGCTGTTCAGCGGCAAGAGGAAATCC
GGGAAGGACTTCGTGACCGAGGCGCTGCAGAGCAGACTTGGAGCTGATGTCTGTGCTGTC
CTCCGGCTCTCTGGTCCACTCAAGGAACAGTATGCTCAGGAGCATGGCTTGAACTTCCAG
AGACTCCTGGACACCAGCACCTACAAGGAGGCCTTTCGGAAGGACATGATCCGCTGGGGA
GAGGAGAAACGCCAGGCTGACCCAGGCTTCTTTTGCAGGAAGATTGTGGAGGGCATCTCC
CAGCCCATCTGGCTGGTGAGTGACACACGGAGAGTGTCTGACATCCAGTGGTTTCGGGAG
GCCTATGGGGCCGTGACGCAGACGGTCCGCGTTGTAGCGTTGGAGCAGAGCCGACAGCAG
CGGGGCTGGGTGTTCACGCCAGGGGTGGACGATGCTGAGTCAGAATGTGGCCTGGACAAC
TTCGGGGACTTTGACTGGGTCATCGAGAACCATGGAGTTGAACAGCGCCTGGAGGAGCAG
TTGGAGAACCTGATAGAATTTATCCGCTCCAGACTTTAG
Protein Properties
Number of Residues 192
Molecular Weight 21994.745
Theoretical pI 5.729
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphomevalonate kinase
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQ
RLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFRE
AYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQ
LENLIEFIRSRL
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q15126
UniProtKB/Swiss-Prot Entry Name PMVK_HUMAN
PDB IDs
GenBank Gene ID L77213
GeneCard ID PMVK
GenAtlas ID PMVK
HGNC ID HGNC:9141
References
General References Not Available