Cannabis Compound Database: Showing Protein Phosphomevalonate kinase (CDBP00955)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00955

Secondary Accession Numbers

Not Available

Name

Phosphomevalonate kinase

Description

Not Available

Synonyms

PMKase
hPMK

Gene Name

PMVK

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphomevalonate kinase activity

Specific Function

Not Available

GO Classification

Biological Process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
cholesterol biosynthetic process
response to cholesterol
Cellular Component
cytosol
peroxisome
Component
cell part
intracellular part
cytoplasm
Function
transferase activity, transferring phosphorus-containing groups
kinase activity
phosphomevalonate kinase activity
catalytic activity
transferase activity
Molecular Function
ATP binding
phosphomevalonate kinase activity
Process
sterol metabolic process
cholesterol metabolic process
metabolic process
small molecule metabolic process
alcohol metabolic process
cholesterol biosynthetic process

Cellular Location

Peroxisome

Pathways

Name	SMPDB/Pathwhiz	KEGG
isopentenyl diphosphate biosynthesis via mevalonate pathway	Not Available	Not Available
Terpenoid backbone biosynthesis	Not Available
Peroxisome	Not Available
Steroid Biosynthesis
Smith-Lemli-Opitz Syndrome (SLOS)		Not Available

Gene Properties

Chromosome Location

Locus

1q22

SNPs

PMVK

Gene Sequence

>579 bp
ATGGCCCCGCTGGGAGGCGCCCCGCGGCTGGTACTGCTGTTCAGCGGCAAGAGGAAATCC
GGGAAGGACTTCGTGACCGAGGCGCTGCAGAGCAGACTTGGAGCTGATGTCTGTGCTGTC
CTCCGGCTCTCTGGTCCACTCAAGGAACAGTATGCTCAGGAGCATGGCTTGAACTTCCAG
AGACTCCTGGACACCAGCACCTACAAGGAGGCCTTTCGGAAGGACATGATCCGCTGGGGA
GAGGAGAAACGCCAGGCTGACCCAGGCTTCTTTTGCAGGAAGATTGTGGAGGGCATCTCC
CAGCCCATCTGGCTGGTGAGTGACACACGGAGAGTGTCTGACATCCAGTGGTTTCGGGAG
GCCTATGGGGCCGTGACGCAGACGGTCCGCGTTGTAGCGTTGGAGCAGAGCCGACAGCAG
CGGGGCTGGGTGTTCACGCCAGGGGTGGACGATGCTGAGTCAGAATGTGGCCTGGACAAC
TTCGGGGACTTTGACTGGGTCATCGAGAACCATGGAGTTGAACAGCGCCTGGAGGAGCAG
TTGGAGAACCTGATAGAATTTATCCGCTCCAGACTTTAG

Protein Properties

Number of Residues

192

Molecular Weight

21994.745

Theoretical pI

5.729

Pfam Domain Function

P-mevalo_kinase (PF04275 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Phosphomevalonate kinase
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQ
RLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFRE
AYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQ
LENLIEFIRSRL

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q15126

UniProtKB/Swiss-Prot Entry Name

PMVK_HUMAN

PDB IDs