Cannabis Compound Database: Showing Protein Diphosphomevalonate decarboxylase (CDBP00954)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00954

Secondary Accession Numbers

Not Available

Name

Diphosphomevalonate decarboxylase

Description

Not Available

Synonyms

MDDase
Mevalonate (diphospho)decarboxylase
Mevalonate pyrophosphate decarboxylase

Gene Name

MVD

Protein Type

Enzyme

Biological Properties

General Function

Involved in ATP binding

Specific Function

Performs the first committed step in the biosynthesis of isoprenes.

GO Classification

Biological Process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isoprenoid biosynthetic process
positive regulation of cell proliferation
cholesterol biosynthetic process
response to drug
Cellular Component
cytosol
Function
adenyl ribonucleotide binding
atp binding
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
diphosphomevalonate decarboxylase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
Molecular Function
diphosphomevalonate decarboxylase activity
ATP binding
protein homodimerization activity
Process
isoprenoid metabolic process
isoprenoid biosynthetic process
phosphorylation
phosphorus metabolic process
phosphate metabolic process
metabolic process
primary metabolic process
cellular metabolic process
lipid metabolic process
cellular lipid metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
cholesterol biosynthesis	Not Available	Not Available
Terpenoid backbone biosynthesis	Not Available
Steroid Biosynthesis
Smith-Lemli-Opitz Syndrome (SLOS)		Not Available
CHILD Syndrome		Not Available

Gene Properties

Chromosome Location

Locus

16q24.3

SNPs

MVD

Gene Sequence

>1203 bp
ATGGCCTCGGAGAAGCCGCTGGCGGCAGTCACTTGTACAGCGCCGGTCAACATCGCGGTC
ATCAAGTACTGGGGCAAGCGCGATGAAGAGCTGGTTCTGCCCATCAACTCCTCCCTGAGC
GTCACTCTGCACCAGGACCAGTTAAAAACCACCACAACAGCCGTCATCAGCAAGGACTTC
ACCGAGGACCGGATTTGGCTGAATGGCCGGGAGGAGGATGTGGGGCAGCCGAGGCTGCAG
GCCTGCCTGCGGGAGATCCGCTGCCTGGCCCGGAAGCGGAGGAACTCACGGGATGGGGAC
CCGCTGCCCTCCAGCCTCAGCTGCAAGGTGCACGTGGCATCGGTGAACAACTTCCCCACG
GCTGCGGGCCTGGCCTCCTCAGCGGCGGGCTATGCCTGCCTAGCCTACACCCTGGCCCGT
GTCTACGGCGTGGAGAGTGACCTCTCAGAAGTGGCTCGCCGGGGCTCAGGCAGCGCCTGC
CGGAGCCTGTATGGGGGCTTTGTGGAGTGGCAGATGGGAGAGCAGGCCGACGGGAAGGAC
AGCATCGCTCGGCAAGTGGCCCCCGAGTCACACTGGCCTGAACTCCGCGTGCTCATCCTT
GTGGTGAGCGCTGAGAAGAAGCTGACAGGCAGTACCGTGGGCATGCGGGCCAGTGTGGAG
ACCAGCCCCCTGCTTCGGTTCCGGGCCGAGTCCGTGGTGCCCGCGCGCATGGCGGAGATG
GCCCGCTGCATCCGGGAGCGAGACTTCCCCAGCTTCGCCCAGCTGACCATGAAGGACAGC
AACCAGTTCCACGCCACCTGCCTCGACACCTTCCCGCCCATCTCTTACCTCAATGCCATC
TCCTGGCGCATCATCCACCTGGTGCACCGCTTCAACGCCCACCACGGGGACACCAAGGTG
GCGTACACCTTTGACGCGGGCCCCAATGCCGTGATCTTCACCCTGGACGACACTGTGGCT
GAGTTTGTGGCTGCTGTGTGGCACGGCTTTCCCCCAGGCTCGAATGGAGACACGTTTCTG
AAGGGGCTGCAGGTGAGGCCGGCCCCTCTCTCAGCTGAGCTTCAGGCTGCGCTGGCCATG
GAGCCGACCCCCGGTGGGGTCAAATACATCATTGTCACTCAGGTGGGGCCAGGGCCTCAA
ATCCTGGATGACCCCTGCGCCCACCTCCTGGGTCCTGACGGCCTGCCGAAGCCAGCTGCC
TGA

Protein Properties

Number of Residues

400

Molecular Weight

43404.125

Theoretical pI

7.228

Pfam Domain Function

GHMP_kinases_N (PF00288 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Diphosphomevalonate decarboxylase
MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDF
TEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPSSLSCKVHVASVNNFPT
AAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKD
SIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEM
ARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKV
AYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQAALAM
EPTPGGVKYIIVTQVGPGPQILDDPCAHLLGPDGLPKPAA

External Links

GenBank ID Protein

12652543

UniProtKB/Swiss-Prot ID

P53602

UniProtKB/Swiss-Prot Entry Name

MVD1_HUMAN

PDB IDs