Cannabis Compound Database: Showing Protein Methylglutaconyl-CoA hydratase, mitochondrial (CDBP00920)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00920

Secondary Accession Numbers

Not Available

Name

Methylglutaconyl-CoA hydratase, mitochondrial

Description

Not Available

Synonyms

AU-binding protein/enoyl-CoA hydratase
AU-specific RNA-binding enoyl-CoA hydratase

Gene Name

AUH

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs.

GO Classification

Biological Process
branched-chain amino acid catabolic process
leucine catabolic process
mRNA catabolic process
Cellular Component
mitochondrial matrix
Function
catalytic activity
Molecular Function
enoyl-CoA hydratase activity
methylglutaconyl-CoA hydratase activity
mRNA 3'-UTR binding
Process
metabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
Valine, Leucine and Isoleucine Degradation
L-leucine degradation	Not Available	Not Available
Beta-Ketothiolase Deficiency		Not Available
2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency		Not Available
Propionic Acidemia		Not Available

Gene Properties

Chromosome Location

Locus

9q22.31

SNPs

AUH

Gene Sequence

>1020 bp
ATGGCGGCCGCGGTGGCGGCGGCACCTGGGGCCTTGGGATCCCTGCATGCTGGCGGCGCC
CGCCTGGTGGCCGCTTGCAGTGCGTGGCTCTGCCCGGGGTTGAGGCTGCCCGGCTCGTTG
GCAGGCCGGCGAGCGGGCCCGGCGATCTGGGCCCAGGGCTGGGTACCTGCGGCCGGGGGT
CCCGCCCCGAAAAGGGGCTACAGCTCTGAGATGAAGACGGAGGACGAGCTGCGGGTGCGG
CACCTGGAGGAGGAGAACCGAGGAATTGTGGTGCTTGGAATAAACAGAGCTTATGGCAAA
AATTCACTCAGTAAAAATCTTATAAAAATGCTATCAAAAGCTGTGGATGCTTTGAAATCT
GATAAGAAAGTACGGACCATAATAATCAGGAGTGAAGTCCCAGGGATATTCTGTGCTGGT
GCTGACCTTAAGGAAAGAGCCAAAATGAGTTCCAGTGAAGTTGGTCCTTTTGTCTCCAAA
ATAAGAGCAGTGATTAACGATATTGCTAATCTTCCAGTGCCAACAATTGCAGCAATAGAT
GGACTCGCTTTAGGTGGTGGTCTTGAACTGGCTTTAGCCTGTGATATACGAGTAGCAGCT
TCCTCTGCAAAAATGGGCCTGGTTGAAACAAAATTGGCGATTATTCCTGGTGGAGGGGGG
ACACAGCGATTGCCACGCGCCATTGGAATGTCCCTGGCCAAGGAGCTCATATTCTCTGCG
CGAGTCCTCGATGGCAAAGAAGCCAAAGCAGTGGGCTTAATCAGCCACGTTCTGGAACAG
AACCAGGAGGGAGACGCGGCCTACAGGAAGGCCTTGGACCTGGCGAGAGAGTTTTTACCT
CAGGGACCTGTTGCAATGAGAGTGGCAAAATTAGCAATTAATCAAGGGATGGAGGTCGAT
TTAGTAACAGGGTTAGCCATAGAAGAAGCTTGTTATGCTCAGACCATTCCAACAAAAGAC
AGACTTGAAGGTCTTCTTGCTTTTAAAGAGAAAAGGCCCCCTCGCTATAAAGGAGAATAA

Protein Properties

Number of Residues

339

Molecular Weight

35608.18

Theoretical pI

9.476

Pfam Domain Function

ECH (PF00378 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Methylglutaconyl-CoA hydratase, mitochondrial
MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIWAQGWVPAAGG
PAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKS
DKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAID
GLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSA
RVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVD
LVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE

External Links

GenBank ID Protein

780241

UniProtKB/Swiss-Prot ID

Q13825

UniProtKB/Swiss-Prot Entry Name

AUHM_HUMAN

PDB IDs

GenBank Gene ID

X79888

GeneCard ID

AUH