| Identification |
|---|
| HMDB Protein ID
| CDBP00811 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB |
| Description
| Not Available |
| Synonyms
|
- Alpha-1,2-mannosidase IB
- Mannosidase alpha class 1A member 2
- Processing alpha-1,2-mannosidase IB
|
| Gene Name
| MAN1A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| Specific Function
| Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
|
| GO Classification
|
| Biological Process |
| post-translational protein modification |
| protein N-linked glycosylation via asparagine |
| lung alveolus development |
| N-glycan processing |
| respiratory gaseous exchange |
| Cellular Component |
| nucleolus |
| integral to membrane |
| Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| calcium ion binding |
| mannosidase activity |
| mannosyl-oligosaccharide mannosidase activity |
| ion binding |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| Molecular Function |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| calcium ion binding |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | N-Glycan biosynthesis | Not Available |  | | Protein processing in endoplasmic reticulum | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p13 |
| SNPs
| MAN1A2 |
| Gene Sequence
|
>1926 bp
ATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGG
CCGCCTTCCTTCCCACATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTC
CTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTTTTCCTTCCAGACTCT
TCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCC
GGTAAAGGGGCTAAAAACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACAC
AGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCATGAGAAGGCCTTGGAA
GAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAG
AAAAATAAGGTAGTCCAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCT
ATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAATGACATAAGAGAGAAA
AGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGG
GGACATAATGAACTCAGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGT
TCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTATATCATGGGACTTCAT
GATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCA
GAGGTGTCTGTGTTTGAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTAC
CTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCTGAGAAACTCCTTCCT
GCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTGGAGTAGGG
CGAAACTGGGGCTGGGCATCTGCAGGTAGCAGCATTCTGGCTGAATTTGGTACACTACAT
ATGGAGTTCATCCACCTCAGCTACTTGACAGGGGACCTGACTTACTACAAAAAGGTTATG
CACATTCGGAAACTACTTCAGAAAATGGATCGTCCAAATGGTCTTTATCCAAATTATTTG
AACCCCAGAACAGGGCGCTGGGGTCAGTATCATACATCTGTCGGTGGCCTGGGAGACAGT
TTTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACAGACCATGAGGCAAGA
AAGATGTATGATGATGCTATTGAGGCTATAGAAAAACATCTTATTAAGAAGTCTCGTGGA
GGTCTTACCTTTATTGGAGAATGGAAGAATGGGCACTTGGAAAAAAAGATGGGGCATTTG
GCCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCCAGAGCAGATAAAGCT
GGTCATTATTTAGAGCTAGGGGCAGAAATTGCACGTACTTGTCATGAGTCATATGACAGA
ACTGCATTAAAGCTAGGTCCTGAATCATTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCT
GTCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATTGAAACCTATTGGTAC
CTATGGCGATTCACTCACGATCCAAGATACAGGCAGTGGGGCTGGGAAGCAGCACTGGCC
ATTGAAAAGTATTGCCGAGTTAATGGTGGGTTTTCTGGAGTCAAAGATGTATATTCCTCT
ACTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAAACATTAAAATATTTG
TATCTGCTGTTCTCCGGTGATGACCTTTTACCTTTAGACCACTGGGTGTTTAATACAGAG
GCTCACCCTCTGCCTGTGTTACATTTAGCCAACACCACACTTTCAGGTAATCCTGCTGTT
CGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 641 |
| Molecular Weight
| 73002.93 |
| Theoretical pI
| 7.605 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDS
SKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKALE
EAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLH
DEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLP
AFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVM
HIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEAR
KMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRADKA
GHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWY
LWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYL
YLLFSGDDLLPLDHWVFNTEAHPLPVLHLANTTLSGNPAVR
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O60476 |
| UniProtKB/Swiss-Prot Entry Name
| MA1A2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF027156 |
| GeneCard ID
| MAN1A2 |
| GenAtlas ID
| MAN1A2 |
| HGNC ID
| HGNC:6822 |
| References |
|---|
| General References
| Not Available |