| Identification |
|---|
| HMDB Protein ID
| CDBP00806 |
| Secondary Accession Numbers
| Not Available |
| Name
| Fumarate hydratase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Fumarase
|
| Gene Name
| FH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in fumarate hydratase activity |
| Specific Function
| Also acts as a tumor suppressor.
|
| GO Classification
|
| Biological Process |
| fumarate metabolic process |
| homeostasis of number of cells within a tissue |
| malate metabolic process |
| tricarboxylic acid cycle |
| Cellular Component |
| mitochondrial matrix |
| tricarboxylic acid cycle enzyme complex |
| Component |
| tricarboxylic acid cycle enzyme complex |
| macromolecular complex |
| protein complex |
| Function |
| hydro-lyase activity |
| fumarate hydratase activity |
| catalytic activity |
| lyase activity |
| carbon-oxygen lyase activity |
| Molecular Function |
| fumarate hydratase activity |
| Process |
| fumarate metabolic process |
| metabolic process |
| cellular metabolic process |
| organic acid metabolic process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
| acetyl-coa metabolic process |
| acetyl-coa catabolic process |
| tricarboxylic acid cycle |
| dicarboxylic acid metabolic process |
|
| Cellular Location
|
- Isoform Cytoplasmic:Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | tricarboxylic acid cycle | Not Available | Not Available | | Citrate cycle (TCA cycle) | Not Available |  | | Renal cell carcinoma | Not Available |  | | Citric Acid Cycle |    | | | Congenital lactic acidosis |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q42.1 |
| SNPs
| FH |
| Gene Sequence
|
>1533 bp
ATGTACCGAGCACTTCGGCTCCTCGCGCGCTCGCGTCCCCTCGTGCGGGCTCCAGCCGCA
GCCTTAGCTTCGGCTCCCGGCTTGGGTGGCGCGGCCGTGCCCTCGTTTTGGCCTCCGAAC
GCGGCTCGAATGGCAAGCCAAAATTCCTTCCGGATAGAATATGATACCTTTGGTGAACTA
AAGGTGCCAAATGATAAGTATTATGGCGCCCAGACCGTGAGATCTACGATGAACTTTAAG
ATTGGAGGTGTGACAGAACGCATGCCAACCCCAGTTATTAAAGCTTTTGGCATCTTGAAG
CGAGCGGCCGCTGAAGTAAACCAGGATTATGGTCTTGATCCAAAGATTGCTAATGCAATA
ATGAAGGCAGCAGATGAGGTAGCTGAAGGTAAATTAAATGATCATTTTCCTCTCGTGGTA
TGGCAGACTGGATCAGGAACTCAGACAAATATGAATGTAAATGAAGTCATTAGCAATAGA
GCAATTGAAATGTTAGGAGGTGAACTTGGCAGCAAGATACCTGTGCATCCCAACGATCAT
GTTAATAAAAGCCAGAGCTCAAATGATACTTTTCCCACAGCAATGCACATTGCTGCTGCA
ATAGAAGTTCATGAAGTACTGTTACCAGGACTACAGAAGTTACATGATGCTCTTGATGCA
AAATCCAAAGAGTTTGCACAGATCATCAAGATTGGACGTACTCATACTCAGGATGCTGTT
CCACTTACTCTTGGGCAGGAATTTAGTGGTTATGTTCAACAAGTAAAATATGCAATGACA
AGAATAAAAGCTGCCATGCCAAGAATCTATGAGCTCGCAGCTGGAGGCACTGCTGTTGGT
ACAGGTTTAAATACTAGAATTGGCTTTGCAGAAAAGGTTGCTGCAAAAGTGGCTGCACTT
ACAGGCTTGCCTTTTGTCACTGCTCCGAATAAATTTGAAGCTCTGGCTGCTCATGACGCT
CTGGTTGAGCTCAGTGGAGCCATGAACACTACTGCCTGCAGTCTGATGAAGATAGCAAAT
GATATTCGATTTTTGGGTTCTGGTCCTCGGTCAGGTCTGGGAGAATTGATCTTGCCTGAA
AATGAACCAGGAAGCAGTATCATGCCAGGCAAGGTGAACCCTACTCAGTGTGAAGCAATG
ACCATGGTTGCAGCCCAAGTCATGGGGAACCATGTTGCTGTCACTGTCGGAGGCAGCAAT
GGACATTTTGAGTTGAATGTTTTCAAGCCAATGATGATTAAAAATGTGTTACACTCAGCC
AGGCTGCTGGGGGATGCTTCAGTTTCCTTTACAGAAAACTGCGTGGTGGGAATCCAGGCC
AATACAGAAAGGATCAACAAGCTGATGAATGAGTCTCTAATGTTGGTGACAGCTCTCAAT
CCTCATATAGGGTATGACAAGGCAGCAAAGATTGCTAAGACAGCACACAAAAATGGATCA
ACCTTAAAGGAAACTGCTATCGAACTTGGCTATCTCACAGCAGAGCAGTTTGACGAATGG
GTAAAACCTAAGGACATGCTGGGTCCAAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 510 |
| Molecular Weight
| 54636.585 |
| Theoretical pI
| 8.758 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Fumarate hydratase, mitochondrial
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL
KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI
MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH
VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV
PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL
TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE
NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA
RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS
TLKETAIELGYLTAEQFDEWVKPKDMLGPK
|
| External Links |
|---|
| GenBank ID Protein
| 13111881 |
| UniProtKB/Swiss-Prot ID
| P07954 |
| UniProtKB/Swiss-Prot Entry Name
| FUMH_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC003108 |
| GeneCard ID
| FH |
| GenAtlas ID
| FH |
| HGNC ID
| HGNC:3700 |
| References |
|---|
| General References
| Not Available |