| Identification |
|---|
| HMDB Protein ID
| CDBP00789 |
| Secondary Accession Numbers
| Not Available |
| Name
| Queuine tRNA-ribosyltransferase |
| Description
| Not Available |
| Synonyms
|
- Guanine insertion enzyme
- tRNA-guanine transglycosylase
|
| Gene Name
| QTRT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in queuine tRNA-ribosyltransferase activity |
| Specific Function
| Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).
|
| GO Classification
|
| Biological Process |
| queuosine biosynthetic process |
| Cellular Component |
| mitochondrion |
| nucleus |
| ribosome |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| queuine trna-ribosyltransferase activity |
| Molecular Function |
| metal ion binding |
| queuine tRNA-ribosyltransferase activity |
| Process |
| trna processing |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| trna modification |
| queuosine biosynthetic process |
| rna metabolic process |
| ncrna metabolic process |
| trna metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | tRNA-queuosine biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| QTRT1 |
| Gene Sequence
|
>1212 bp
ATGGCGGGAGCAGCTACCCAGGCTTCCCTGGAGTCGGCCCCACGGATCATGCGGCTGGTG
GCCGAATGCAGCCGCTCCAGGGCCCGGGCAGGCGAGCTGTGGCTGCCGCATGGGACAGTG
GCCACTCCTGTGTTCATGCCAGTGGGCACGCAGGCCACCATGAAGGGCATCACGACCGAA
CAGCTGGACGCTCTGGGTTGCCGCATCTGCCTGGGCAATACCTACCATCTGGGTCTAAGG
CCGGGACCCGAGCTGATCCAGAAAGCCAACGGTCTCCACGGCTTCATGAATTGGCCTCAT
AATCTGCTAACGGACAGCGGCGGTTTCCAGATGGTGTCGCTGGTGTCTCTGTCCGAGGTG
ACGGAGGAGGGCGTCCGCTTCCGCTCCCCCTACGACGGCAATGAGACCCTGCTGAGCCCG
GAGAAATCCGTGCAGATCCAGAATGCGCTGGGCTCGGACATCATCATGCAGCTGGACGAC
GTGGTTAGCAGTACTGTGACTGGGCCACGTGTGGAGGAGGCCATGTACAGGTCAATCCGC
TGGCTGGACCGGTGCATTGCAGCCCATCAGCGGCCGGACAAGCAGAACCTCTTCGCCATT
ATCCAGGGTGGGCTGGACGCAGATCTCCGGGCCACCTGCCTTGAAGAGATGACCAAGCGA
GACGTGCCTGGCTTCGCCATCGGGGGCCTGAGCGGGGGTGAGAGCAAGTCGCAGTTCTGG
CGGATGGTGGCGCTGAGCACCTCTCGGCTGCCGAAGGACAAGCCCCGATATCTGATGGGG
GTTGGCTATGCCACTGATCTGGTAGTCTGCGTGGCTCTTGGATGTGACATGTTCGACTGC
GTCTTCCCCACACGGACAGCGCGCTTTGGCTCTGCCCTGGTGCCCACTGGGAACCTGCAG
TTGAGGAAGAAGGTGTTTGAGAAGGACTTCGGCCCCATAGACCCGGAGTGCACCTGCCCC
ACGTGCCAAAAGCACAGCCGCGCCTTCCTGCACGCACTGCTGCACAGTGACAACACGGCC
GCGCTGCACCACCTCACGGTCCACAACATCGCCTACCAGCTGCAGCTCATGAGCGCCGTC
CGCACCAGCATCGTGGAGAAGCGCTTCCCGGACTTCGTGCGGGACTTCATGGGCGCCATG
TACGGGGATCCCACCCTCTGTCCCACCTGGGCCACTGACGCTCTGGCCTCTGTGGGAATC
ACACTTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 403 |
| Molecular Weight
| 44047.3 |
| Theoretical pI
| 7.229 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Queuine tRNA-ribosyltransferase
MAGAATQASLESAPRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTE
QLDALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVSLVSLSEV
TEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIR
WLDRCIAAHQRPDKQNLFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFW
RMVALSTSRLPKDKPRYLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQ
LRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAV
RTSIVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9BXR0 |
| UniProtKB/Swiss-Prot Entry Name
| TGT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF302783 |
| GeneCard ID
| QTRT1 |
| GenAtlas ID
| QTRT1 |
| HGNC ID
| HGNC:23797 |
| References |
|---|
| General References
| Not Available |