Identification |
HMDB Protein ID
| CDBP00780 |
Secondary Accession Numbers
| Not Available |
Name
| Glycerol kinase 2 |
Description
| Not Available |
Synonyms
|
- ATP:glycerol 3-phosphotransferase 2
- GK 2
- Glycerokinase 2
- Glycerol kinase, testis specific 2
|
Gene Name
| GK2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in phosphotransferase activity, alcohol group as acceptor |
Specific Function
| Key enzyme in the regulation of glycerol uptake and metabolism (By similarity).
|
GO Classification
|
Biological Process |
glycerol metabolic process |
glycerol catabolic process |
glycerol-3-phosphate metabolic process |
Cellular Component |
mitochondrial outer membrane |
Function |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
phosphotransferase activity, alcohol group as acceptor |
glycerol kinase activity |
catalytic activity |
Molecular Function |
ATP binding |
glycerol kinase activity |
Process |
metabolic process |
primary metabolic process |
carbohydrate metabolic process |
small molecule metabolic process |
alcohol metabolic process |
polyol metabolic process |
alditol metabolic process |
glycerol metabolic process |
glycerol-3-phosphate metabolic process |
|
Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic side
- Mitochondrion outer membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | glycerol degradation via glycerol kinase pathway | Not Available | Not Available | PPAR signaling pathway | Not Available | |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q13 |
SNPs
| GK2 |
Gene Sequence
|
>1662 bp
ATGGCAGCCCCGAAGACAGCAGCTGTGGGGCCGTTGGTGGGAGCGGTGGTCCAGGGCACC
AACTCCACTCGCTTTCTGGTTTTCAATTCAAAAACAGCGGAACTACTTAGTCATCACAAA
GTGGAATTAACACAAGAGTTCCCAAAAGAAGGATGGGTGGAACAAGACCCTAAAGAAATT
CTTCAGTCTGTCTACGAGTGTATAGCGAGAACGTGTGAGAAACTTGACGAACTGAATATT
GATATATCCAACATAAAAGCTGTTGGTGTCAGCAATCAGAGGGAAACCACTGTAATCTGG
GACAAGTTAACAGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
ACTACTGTTGAGGATCTTAGTAAAAAAATTCCAGGAAATAGTAACTTCGTCAAGTCTAAG
ACAGGCCTTCCACTCAGCACTTACTTCAGTGCAGTAAAACTTCGTTGGATGCTTGACAAT
GTGAGAAACGTCCAAAAGGCTGTTGAAGAAGGTAGAGCTCTTTTTGGTACCATTGATTCA
TGGCTTATCTGGAGTTTGACAGGAGGAGTTAATGGAGGCGTGCATTGTACAGATGTAACA
AATGCAAGTAGGACAATGCTTTTTAATATCCATTCTTTGGAATGGGATAAAGAGCTCTGT
GACTTTTTTGAAATTCCAATGGACCTTCTTCCAAATGTCTTCAGTTCTTCTGGGATCTAT
GGCCTAATTAAAACTGGAGCCCTGGAAGGTGTGCCAATATCTGGGTGTTTGGGGGACCAA
TGTGCTGCATTAGTAGGACAAATGTGCTTCCAGGAGGGACAAGCCAAAAACACCTATGGA
ACAGGTTGCTTCTTACTGTGTAATACGGGTCGTAAATGTGTGTTTTCTGAACATGGCCTT
TTGACCACAGTAGCTTACAAACTAGGCAGAGAGAAGCCAGCATATTATGCACTGGAAGGT
TCTGTTGCTATAGCAGGTGCTGTTATTCGTTGGCTAAGAGACAATCTTGGAATTATAGAG
ACCTCAGGAGACATTGAAAGACTTGCTAAAGAAGTAGGAACTTCTTATGGCTGTTACTTT
GTCCCAGCCTTTTCAGGGTTATATACACCTTATTGGGAGCCTAGTGCAAGAGGGATACTC
TGTGGCCTCACTCAGTTTACCAATAAATGTCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACCCGAGAGATTTTGGAAGCCATGAACCGTGACTGTGGAATTCCACTTCGT
CATTTGCAGGTAGATGGAGGAATGACCAACAACAAAGTTCTTATGCAGCTACAAGCAGAT
ATTCTTCATATTCCAGTAATAAAACCCTTTATGCCTGAAACAACTGCACTAGGAGCTGCC
ATGGCAGCAGGGGCTGCAGAGGGAGTAAGCGTTTGGAGCCTTGAACCCCAGGCTTTGTCA
GTTCTCAGGATGGAACGATTTGAACCACAGATCCAGGCCACAGAAAGTGAAATTTGTTAT
GCCACATGGAAGAAAGCCGTAATGAAGTCAATGGGTTGGGTTACCAGTCAGTCTCCTGAA
GGTGGTGATCCTTCTATCTTCTCTAGTCTGCCTTTGGGATTTTTTATAGTGAGTAGCATG
GTAATGCTAATTGGAGCAAGATATATCTCGGGTGTGCCATAA
|
Protein Properties |
Number of Residues
| 553 |
Molecular Weight
| 60593.32 |
Theoretical pI
| 5.776 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Glycerol kinase 2
MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEI
LQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQ
TTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIY
GLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGL
LTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLR
HLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALS
VLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSM
VMLIGARYISGVP
|
External Links |
GenBank ID Protein
| 158257914 |
UniProtKB/Swiss-Prot ID
| Q14410 |
UniProtKB/Swiss-Prot Entry Name
| GLPK2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK292241 |
GeneCard ID
| GK2 |
GenAtlas ID
| GK2 |
HGNC ID
| HGNC:4291 |
References |
General References
| Not Available |