Identification |
HMDB Protein ID
| CDBP00749 |
Secondary Accession Numbers
| Not Available |
Name
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
Description
| Not Available |
Synonyms
|
- 6-phosphofructo-2-kinase
- 6PF-2-K/Fru-2,6-P2ase 2
- 6PF-2-K/Fru-2,6-P2ase heart-type isozyme
- Fructose-2,6-bisphosphatase
- PFK/FBPase 2
|
Gene Name
| PFKFB2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Synthesis and degradation of fructose 2,6-bisphosphate.
|
GO Classification
|
Biological Process |
small molecule metabolic process |
fructose metabolic process |
glycolysis |
positive regulation of insulin secretion |
pyruvate metabolic process |
response to glucose stimulus |
positive regulation of glucokinase activity |
fructose 2,6-bisphosphate metabolic process |
lactate metabolic process |
Cellular Component |
cytosol |
Function |
transferase activity, transferring phosphorus-containing groups |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
phosphotransferase activity, alcohol group as acceptor |
phosphofructokinase activity |
6-phosphofructo-2-kinase activity |
binding |
catalytic activity |
transferase activity |
Molecular Function |
ATP binding |
fructose-2,6-bisphosphate 2-phosphatase activity |
6-phosphofructo-2-kinase activity |
Process |
hexose metabolic process |
fructose metabolic process |
fructose 2,6-bisphosphate metabolic process |
metabolic process |
small molecule metabolic process |
alcohol metabolic process |
monosaccharide metabolic process |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Fructose and mannose metabolism | Not Available | | HIF-1 signaling pathway | Not Available | |
|
Gene Properties |
Chromosome Location
| 1 |
Locus
| 1q31 |
SNPs
| PFKFB2 |
Gene Sequence
|
>1518 bp
ATGTCTGGGGCATCTTCCTCAGAACAGAACAACAACAGCTATGAAACCAAAACCCCAAAT
CTTCGAATGTCAGAGAAGAAATGTTCATGGGCCTCCTACATGACCAACTCCCCGACTCTG
ATCGTTATGATTGGTTTGCCAGCCCGGGGTAAAACCTACGTGTCCAAGAAACTAACACGC
TACCTCAACTGGATTGGAGTCCCCACCAAAGTGTTTAATCTTGGGGTGTATCGGCGTGAA
GCAGTCAAGTCCTATAAGTCCTACGACTTCTTTCGGCATGACAATGAGGAGGCCATGAAG
ATCCGCAAACAGTGTGCTCTGGTGGCGCTGGAAGATGTTAAGGCGTATCTCACTGAGGAG
AATGGTCAGATTGCGGTGTTTGATGCCACCAATACAACCCGGGAGAGGAGGGACATGATT
TTGAACTTTGCTGAACAGAATTCCTTCAAGGTATTCTTTGTGGAATCCGTCTGTGATGAT
CCTGATGTCATTGCTGCCAATATTCTGGAGGTTAAGGTATCAAGCCCTGACTATCCTGAA
AGGAACAGAGAGAACGTGATGGAGGACTTCCTGAAGAGAATTGAATGCTACAAAGTTACC
TACCGACCTCTTGACCCAGACAACTATGACAAGGATCTTTCTTTCATCAAGGTGATAAAC
GTGGGCCAGCGATTTTTAGTCAACAGAGTCCAGGACTACATCCAGAGCAAGATAGTCTAC
TACCTCATGAATATCCACGTCCAGCCTCGCACCATTTACCTTTGCCGGCATGGAGAAAGC
GAGTTCAATCTCTTGGGGAAGATTGGGGGTGACTCTGGCCTCTCGGTGCGGGGAAAGCAG
TTTGCCCAAGCTCTAAGGAAATTTCTGGAGGAACAGGAAATAACAGACCTCAAAGTGTGG
ACAAGCCAGTTGAAGAGGACCATACAGACTGCTGAATCTCTCGGGGTGCCCTATGAGCAG
TGGAAGATTCTGAATGAGATTGATGCTGGTGTGTGTGAAGAGATGACCTATGCAGAGATT
GAGAAACGGTACCCAGAAGAGTTTGCACTTCGAGATCAAGAGAAGTATCTGTATCGATAT
CCTGGTGGGGAGTCATACCAGGACCTGGTGCAGCGGCTGGAGCCTGTCATCATGGAGCTG
GAACGTCAGGGCAATGTCCTCGTCATCTCCCACCAGGCTGTCATGCGCTGCCTCCTGGCC
TACTTCTTGGATAAGGGCGCAGATGAGCTACCATACTTGAGATGCCCTCTCCATACCATC
TTCAAACTTACTCCTGTGGCCTATGGGTGCAAAGTGGAAACAATTAAACTTAACGTGGAG
GCTGTGAACACGCACCGTGACAAGCCAACTAACAACTTCCCCAAGAACCAAACCCCTGTA
AGGATGAGAAGGAACAGCTTTACGCCTCTGTCCAGTTCGAATACAATAAGGCGTCCAAGA
AATTACAGTGTTGGGAGCCGGCCCCTCAAGCCCCTCAGCCCTCTCCGTGCCCAGGACATG
CAAGAAGGGGCCGACTAG
|
Protein Properties |
Number of Residues
| 505 |
Molecular Weight
| 54405.88 |
Theoretical pI
| 7.564 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTR
YLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEE
NGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPE
RNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVY
YLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVW
TSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY
PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTI
FKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPR
NYSVGSRPLKPLSPLRAQDMQEGAD
|
External Links |
GenBank ID Protein
| 64762406 |
UniProtKB/Swiss-Prot ID
| O60825 |
UniProtKB/Swiss-Prot Entry Name
| F262_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_006212.2 |
GeneCard ID
| PFKFB2 |
GenAtlas ID
| PFKFB2 |
HGNC ID
| HGNC:8873 |
References |
General References
| Not Available |