| Identification |
|---|
| HMDB Protein ID
| CDBP00748 |
| Secondary Accession Numbers
| Not Available |
| Name
| Fructose-1,6-bisphosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
- FBPase 1
|
| Gene Name
| FBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphoric ester hydrolase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of gluconeogenesis |
| small molecule metabolic process |
| fructose metabolic process |
| cellular response to drug |
| cellular response to insulin stimulus |
| gluconeogenesis |
| negative regulation of cell growth |
| cellular response to magnesium ion |
| fructose 6-phosphate metabolic process |
| negative regulation of glycolysis |
| negative regulation of Ras protein signal transduction |
| protein homotetramerization |
| Cellular Component |
| cytosol |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| Molecular Function |
| metal ion binding |
| monosaccharide binding |
| AMP binding |
| fructose 1,6-bisphosphate 1-phosphatase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | Fructose and mannose metabolism | Not Available |  | | Insulin signaling pathway | Not Available |  | | Fructose and Mannose Degradation |    | | | Fructosuria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q22.3 |
| SNPs
| FBP1 |
| Gene Sequence
|
>1017 bp
ATGGCTGACCAGGCGCCCTTCGACACGGACGTCAACACCCTGACCCGCTTCGTCATGGAG
GAGGGCAGGAAGGCCCGCGGCACGGGCGAGTTGACCCAGCTGCTCAACTCGCTCTGCACA
GCAGTCAAAGCCATCTCTTCGGCGGTGCGCAAGGCGGGCATCGCGCACCTCTATGGCATT
GCTGGTTCTACCAACGTGACAGGTGATCAAGTTAAGAAGCTGGACGTCCTCTCCAACGAC
CTGGTTATGAACATGTTAAAGTCATCCTTTGCCACGTGTGTTCTCGTGTCAGAAGAAGAT
AAACACGCCATCATAGTGGAACCGGAGAAAAGGGGTAAATATGTGGTCTGTTTTGATCCC
CTTGATGGATCTTCCAACATCGATTGCCTTGTGTCCGTTGGAACCATTTTTGGCATCTAT
AGAAAGAAATCAACTGATGAGCCTTCTGAGAAGGATGCTCTGCAACCAGGCCGGAACCTG
GTGGCAGCCGGCTACGCACTGTATGGCAGTGCCACCATGCTGGTCCTTGCCATGGACTGT
GGGGTCAACTGCTTCATGCTGGACCCGGCCATCGGGGAGTTCATTTTGGTGGACAAGGAT
GTGAAGATAAAAAAGAAAGGTAAAATCTACAGCCTTAACGAGGGCTACGCCAGGGACTTT
GACCCTGCCGTCACTGAGTACATCCAGAGGAAGAAGTTCCCCCCAGATAATTCAGCTCCT
TATGGGGCCCGGTATGTGGGCTCCATGGTGGCTGATGTTCATCGCACTCTGGTCTACGGA
GGGATATTTCTGTACCCCGCTAACAAGAAGAGCCCCAATGGAAAGCTGAGACTGCTGTAC
GAATGCAACCCCATGGCCTACGTCATGGAGAAGGCTGGGGGAATGGCCACCACTGGGAAG
GAGGCCGTGTTAGACGTCATTCCCACAGACATTCACCAGAGGGCGCCGGTGATCTTGGGA
TCCCCCGACGACGTGCTCGAGTTCCTGAAGGTGTATGAGAAGCACTCTGCCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 338 |
| Molecular Weight
| 36842.145 |
| Theoretical pI
| 6.986 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Fructose-1,6-bisphosphatase 1
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
|
| External Links |
|---|
| GenBank ID Protein
| 16579888 |
| UniProtKB/Swiss-Prot ID
| P09467 |
| UniProtKB/Swiss-Prot Entry Name
| F16P1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_000507.3 |
| GeneCard ID
| FBP1 |
| GenAtlas ID
| FBP1 |
| HGNC ID
| HGNC:3606 |
| References |
|---|
| General References
| Not Available |