Identification |
HMDB Protein ID
| CDBP00742 |
Secondary Accession Numbers
| Not Available |
Name
| Mannose-6-phosphate isomerase |
Description
| Not Available |
Synonyms
|
- PMI
- Phosphohexomutase
- Phosphomannose isomerase
|
Gene Name
| MPI |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in mannose-6-phosphate isomerase activity |
Specific Function
| Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
|
GO Classification
|
Biological Process |
GDP-mannose biosynthetic process |
dolichol-linked oligosaccharide biosynthetic process |
post-translational protein modification |
protein N-linked glycosylation via asparagine |
Cellular Component |
cytosol |
Function |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
transition metal ion binding |
zinc ion binding |
mannose-6-phosphate isomerase activity |
isomerase activity |
intramolecular oxidoreductase activity |
intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
Molecular Function |
mannose-6-phosphate isomerase activity |
metal ion binding |
zinc ion binding |
Process |
metabolic process |
primary metabolic process |
carbohydrate metabolic process |
|
Cellular Location
|
- Cytoplasm (Probable)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | GDP-alpha-D-mannose biosynthesis | Not Available | Not Available | Fructose and mannose metabolism | Not Available | | Amino sugar and nucleotide sugar metabolism | Not Available | | Fructose and Mannose Degradation | | | Fructosuria | | Not Available |
|
Gene Properties |
Chromosome Location
| 15 |
Locus
| 15q22-qter |
SNPs
| MPI |
Gene Sequence
|
>1272 bp
ATGGCCGCTCCGCGAGTATTCCCACTTTCCTGTGCGGTGCAGCAGTATGCCTGGGGGAAG
ATGGGTTCCAACAGCGAAGTGGCGCGGCTGTTGGCCAGCAGTGATCCACTGGCCCAGATC
GCAGAGGACAAGCCTTATGCAGAGTTGTGGATGGGGACTCACCCCCGAGGGGATGCCAAG
ATCCTTGACAACCGCATCTCACAGAAGACCCTAAGCCAGTGGATTGCTGAGAACCAGGAC
AGCTTGGGCTCAAAGGTCAAGGACACCTTTAATGGCAACCTGCCCTTCCTCTTCAAAGTG
CTCTCAGTTGAAACACCCCTGTCCATCCAGGCACACCCTAACAAGGAGCTGGCAGAGAAG
CTGCACCTCCAGGCTCCGCAGCACTACCCCGATGCCAACCACAAGCCAGAGATGGCCATT
GCCCTCACCCCCTTCCAGGGCTTGTGTGGCTTCCGGCCAGTTGAGGAGATTGTAACCTTT
CTAAAGAAGGTGCCTGAGTTTCAGTTCCTGATTGGAGATGAGGCAGCAACACACCTGAAG
CAGACCATGAGCCATGACTCCCAGGCTGTGGCCTCCTCTCTGCAGAGCTGTTTCTCCCAC
CTGATGAAGAGTGAGAAGAAGGTGGTGGTGGAACAGCTCAACCTGTTGGTGAAGCGGATC
TCCCAGCAAGCGGCTGCCGGAAACAACATGGAGGACATCTTTGGGGAGCTTTTGCTACAG
CTGCACCAGCAGTACCCAGGTGATATCGGCTGCTTTGCCATCTACTTCCTGAACCTGCTT
ACCCTGAAGCCTGGGGAGGCCATGTTTCTGGAGGCCAACGTACCCCATGCCTACCTGAAA
GGAGACTGCGTGGAGTGCATGGCGTGTTCAGACAACACAGTTCGTGCTGGCCTGACACCC
AAGTTCATTGATGTGCCAACCCTGTGTGAAATGCTCAGCTATACCCCTAGCTCCAGCAAG
GACAGGCTCTTTCTCCCAACACGGAGTCAGGAAGACCCCTACCTCTCAATCTATGACCCC
CCTGTACCAGACTTCACCATTATGAAGACGGAGGTCCCTGGCTCTGTCACTGAATACAAG
GTCTTGGCACTGGACTCTGCCAGCATCCTCCTGATGGTACAGGGGACAGTAATAGCCAGC
ACACCCACAACCCAGACACCAATCCCTCTGCAACGTGGTGGCGTGCTCTTCATTGGGGCC
AATGAGAGTGTCTCACTGAAGCTTACTGAGCCGAAGGACCTGCTGATATTCCGTGCCTGC
TGTCTGCTGTAA
|
Protein Properties |
Number of Residues
| 423 |
Molecular Weight
| 46655.44 |
Theoretical pI
| 5.949 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Mannose-6-phosphate isomerase
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
|
External Links |
GenBank ID Protein
| 416017 |
UniProtKB/Swiss-Prot ID
| P34949 |
UniProtKB/Swiss-Prot Entry Name
| MPI_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| X76057 |
GeneCard ID
| MPI |
GenAtlas ID
| MPI |
HGNC ID
| HGNC:7216 |
References |
General References
| Not Available |