| Identification |
|---|
| HMDB Protein ID
| CDBP00719 |
| Secondary Accession Numbers
| Not Available |
| Name
| Type 2 lactosamine alpha-2,3-sialyltransferase |
| Description
| Not Available |
| Synonyms
|
- CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
- ST3Gal VI
- ST3GalVI
- Sialyltransferase 10
|
| Gene Name
| ST3GAL6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sialyltransferase activity |
| Specific Function
| Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| intrinsic to organelle membrane |
| intrinsic to golgi membrane |
| integral to golgi membrane |
| Function |
| sialyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring glycosyl groups |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
| protein amino acid glycosylation |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q12.1 |
| SNPs
| ST3GAL6 |
| Gene Sequence
|
>996 bp
ATGAGAGGGTATCTTGTGGCCATATTCCTGAGTGCTGTCTTCCTCTATTATGTACTGCAT
TGCATATTATGGGGAACGAATGTCTATTGGGTGGCACCTGTGGAAATGAAACGGAGAAAT
AAGATCCAGCCTTGTTTATCAAAGCCAGCTTTTGCCTCTCTGCTGAGGTTTCATCAGTTT
CACCCTTTTCTGTGTGCGGCTGATTTTAGAAAGATTGCTTCCTTGTATGGTAGCGATAAG
TTTGATTTGCCCTATGGGATGAGAACATCAGCGGAATATTTTCGACTTGCTCTTTCAAAA
CTGCAGAGTTGTGATCTCTTTGATGAGTTTGACAACATACCCTGTAAAAAGTGTGTGGTG
GTTGGTAATGGAGGAGTTTTGAAGAATAAGACATTAGGAGAAAAAATCGACTCCTATGAT
GTAATAATAAGAATGAATAATGGTCCTGTTTTAGGACATGAAGAAGAAGTTGGGAGAAGG
ACAACCTTCCGACTTTTTTATCCAGAATCTGTTTTTTCAGATCCTATTCACAATGACCCT
AATACGACAGTGATTCTCACTGCTTTTAAGCCACATGATTTAAGGTGGCTGTTGGAATTG
TTGATGGGTGACAAAATAAACACTAATGGTTTTTGGAAGAAACCAGCCTTAAACCTGATT
TATAAACCTTATCAAATCCGAATATTAGATCCTTTCATTATCAGAACAGCAGCTTATGAA
CTGCTTCATTTTCCAAAAGTGTTTCCCAAAAATCAGAAACCTAAACACCCAACAACAGGA
ATTATTGCCATCACATTGGCGTTTTACATATGTCACGAAGTTCACCTAGCTGGTTTTAAA
TACAACTTTTCTGACCTCAAGAGTCCTTTGCACTACTATGGGAATGCCACCATGTCTTTG
ATGAATAAGAACGCGTATCACAATGTGACTGCAGAGCAGCTCTTTTTGAAGGACATTATA
GAAAAAAACCTCGTAATCAACTTGACTCAAGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 331 |
| Molecular Weight
| 38213.3 |
| Theoretical pI
| 9.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Type 2 lactosamine alpha-2,3-sialyltransferase
MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLLRFHQF
HPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVV
VGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDP
NTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYE
LLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSL
MNKNAYHNVTAEQLFLKDIIEKNLVINLTQD
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9Y274 |
| UniProtKB/Swiss-Prot Entry Name
| SIA10_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB022918 |
| GeneCard ID
| ST3GAL6 |
| GenAtlas ID
| ST3GAL6 |
| HGNC ID
| HGNC:18080 |
| References |
|---|
| General References
| Not Available |