Identification
HMDB Protein ID CDBP00713
Secondary Accession Numbers Not Available
Name Deoxyguanosine kinase, mitochondrial
Description Not Available
Synonyms
  1. dGK
Gene Name DGUOK
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
GO Classification
Biological Process
purine-containing compound salvage
dGTP metabolic process
guanosine metabolic process
negative regulation of neuron projection development
protein phosphorylation
purine deoxyribonucleoside metabolic process
purine nucleobase metabolic process
Cellular Component
cytosol
mitochondrial matrix
Function
atp binding
phosphotransferase activity, alcohol group as acceptor
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
Molecular Function
phosphotransferase activity, alcohol group as acceptor
ATP binding
deoxyguanosine kinase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Cellular Location
  1. Mitochondrion
Pathways
Gene Properties
Chromosome Location 2
Locus 2p13
SNPs DGUOK
Gene Sequence
>834 bp
ATGGCCGCGGGCCGCCTCTTTCTAAGTCGGCTTCGAGCACCCTTCAGTTCCATGGCCAAG
AGCCCACTCGAGGGCGTTTCCTCCTCCAGAGGCCTGCACGCGGGGCGCGGGCCCCGAAGG
CTCTCCATCGAAGGCAACATTGCTGTGGGAAAGTCCACGTTTGTGAAGTTACTCACGAAA
ACTTACCCAGAATGGCACGTAGCTACAGAACCTGTAGCAACATGGCAGAATATCCAGGCT
GCTGGCACCCAAAAAGCCTGCACTGCCCAAAGTCTTGGAAACTTGCTGGATATGATGTAC
CGGGAGCCAGCACGATGGTCCTACACATTCCAGACATTTTCCTTTTTGAGCCGCCTGAAA
GTACAGCTGGAGCCCTTCCCTGAGAAACTCTTACAGGCCAGGAAGCCAGTACAGATCTTT
GAGAGGTCTGTGTACAGTGACAGGTATATCTTTGCAAAGAATCTTTTTGAAAATGGTTCC
CTCAGTGACATCGAGTGGCATATCTATCAGGACTGGCATTCTTTTCTCCTGTGGGAGTTT
GCCAGCCGGATCACATTACATGGCTTCATCTACCTCCAGGCTTCTCCCCAGGTTTGTTTG
AAGAGACTGTACCAGAGGGCCAGGGAGGAGGAGAAAGGAATTGAGCTGGCCTATCTAGAG
CAGCTGCATGGCCAACACGAAGCCTGGCTTATTCACAAGACAACGAAGCTCCACTTTGAG
GCTCTGATGAACATTCCAGTGCTGGTGTTGGATGTCAATGATGATTTTTCTGAGGAAGTA
ACCAAACAAGAAGACCTCATGAGAGAGGTAAACACCTTTGTAAAGAATCTGTAA
Protein Properties
Number of Residues 277
Molecular Weight 32055.53
Theoretical pI 8.661
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Deoxyguanosine kinase, mitochondrial
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK
VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF
ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE
ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
GenBank ID Protein 16041753
UniProtKB/Swiss-Prot ID Q16854
UniProtKB/Swiss-Prot Entry Name DGUOK_HUMAN
PDB IDs
GenBank Gene ID BC015757
GeneCard ID DGUOK
GenAtlas ID DGUOK
HGNC ID HGNC:2858
References
General References Not Available