Identification |
HMDB Protein ID
| CDBP00713 |
Secondary Accession Numbers
| Not Available |
Name
| Deoxyguanosine kinase, mitochondrial |
Description
| Not Available |
Synonyms
|
- dGK
|
Gene Name
| DGUOK |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in ATP binding |
Specific Function
| Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
|
GO Classification
|
Biological Process |
purine-containing compound salvage |
dGTP metabolic process |
guanosine metabolic process |
negative regulation of neuron projection development |
protein phosphorylation |
purine deoxyribonucleoside metabolic process |
purine nucleobase metabolic process |
Cellular Component |
cytosol |
mitochondrial matrix |
Function |
atp binding |
phosphotransferase activity, alcohol group as acceptor |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
Molecular Function |
phosphotransferase activity, alcohol group as acceptor |
ATP binding |
deoxyguanosine kinase activity |
Process |
metabolic process |
nitrogen compound metabolic process |
cellular nitrogen compound metabolic process |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|
Cellular Location
|
- Mitochondrion
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Purine Metabolism | | | Adenosine Deaminase Deficiency | | Not Available | Adenylosuccinate Lyase Deficiency | | Not Available | Gout or Kelley-Seegmiller Syndrome | | Not Available | Lesch-Nyhan Syndrome (LNS) | | Not Available |
|
Gene Properties |
Chromosome Location
| 2 |
Locus
| 2p13 |
SNPs
| DGUOK |
Gene Sequence
|
>834 bp
ATGGCCGCGGGCCGCCTCTTTCTAAGTCGGCTTCGAGCACCCTTCAGTTCCATGGCCAAG
AGCCCACTCGAGGGCGTTTCCTCCTCCAGAGGCCTGCACGCGGGGCGCGGGCCCCGAAGG
CTCTCCATCGAAGGCAACATTGCTGTGGGAAAGTCCACGTTTGTGAAGTTACTCACGAAA
ACTTACCCAGAATGGCACGTAGCTACAGAACCTGTAGCAACATGGCAGAATATCCAGGCT
GCTGGCACCCAAAAAGCCTGCACTGCCCAAAGTCTTGGAAACTTGCTGGATATGATGTAC
CGGGAGCCAGCACGATGGTCCTACACATTCCAGACATTTTCCTTTTTGAGCCGCCTGAAA
GTACAGCTGGAGCCCTTCCCTGAGAAACTCTTACAGGCCAGGAAGCCAGTACAGATCTTT
GAGAGGTCTGTGTACAGTGACAGGTATATCTTTGCAAAGAATCTTTTTGAAAATGGTTCC
CTCAGTGACATCGAGTGGCATATCTATCAGGACTGGCATTCTTTTCTCCTGTGGGAGTTT
GCCAGCCGGATCACATTACATGGCTTCATCTACCTCCAGGCTTCTCCCCAGGTTTGTTTG
AAGAGACTGTACCAGAGGGCCAGGGAGGAGGAGAAAGGAATTGAGCTGGCCTATCTAGAG
CAGCTGCATGGCCAACACGAAGCCTGGCTTATTCACAAGACAACGAAGCTCCACTTTGAG
GCTCTGATGAACATTCCAGTGCTGGTGTTGGATGTCAATGATGATTTTTCTGAGGAAGTA
ACCAAACAAGAAGACCTCATGAGAGAGGTAAACACCTTTGTAAAGAATCTGTAA
|
Protein Properties |
Number of Residues
| 277 |
Molecular Weight
| 32055.53 |
Theoretical pI
| 8.661 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Deoxyguanosine kinase, mitochondrial
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK
VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF
ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE
ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
|
External Links |
GenBank ID Protein
| 16041753 |
UniProtKB/Swiss-Prot ID
| Q16854 |
UniProtKB/Swiss-Prot Entry Name
| DGUOK_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| BC015757 |
GeneCard ID
| DGUOK |
GenAtlas ID
| DGUOK |
HGNC ID
| HGNC:2858 |
References |
General References
| Not Available |