Cannabis Compound Database: Showing Protein 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CDBP00662)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00662

Secondary Accession Numbers

Not Available

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 2

Description

Not Available

Synonyms

5 alpha-SR2
S5AR 2
SR type 2
Steroid 5-alpha-reductase 2
Type II 5-alpha reductase

Gene Name

SRD5A2

Protein Type

Enzyme

Biological Properties

General Function

Involved in 3-oxo-5-alpha-steroid 4-dehydrogenase activity

Specific Function

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

GO Classification

Biological Process
small molecule metabolic process
cell-cell signaling
cell differentiation
male gonad development
androgen biosynthetic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Component
intracellular part
cytoplasm
membrane part
intrinsic to membrane
integral to membrane
membrane
cell part
Function
oxidoreductase activity, acting on the ch-ch group of donors
catalytic activity
steroid dehydrogenase activity, acting on the ch-ch group of donors
3-oxo-5-alpha-steroid 4-dehydrogenase activity
oxidoreductase activity
steroid dehydrogenase activity
Molecular Function
sterol 5-alpha reductase activity
3-oxo-5-alpha-steroid 4-dehydrogenase activity
cholestenone 5-alpha-reductase activity
Process
oxidation reduction
lipid metabolic process
steroid metabolic process
metabolic process
primary metabolic process

Cellular Location

Multi-pass membrane protein (Potential)
Endoplasmic reticulum membrane
Multi-pass membrane protein
Microsome membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Steroid hormone biosynthesis	Not Available
Prostate cancer	Not Available

Gene Properties

Chromosome Location

Locus

2p23

SNPs

SRD5A2

Gene Sequence

>765 bp
ATGCAGGTTCAGTGCCAGCAGAGCCCAGTGCTGGCAGGCAGCGCCACTTTGGTCGCCCTT
GGGGCACTGGCCTTGTACGTCGCGAAGCCCTCCGGCTACGGGAAGCACACGGAGAGCCTG
AAGCCGGCGGCTACCCGCCTGCCAGCCCGCGCCGCCTGGTTCCTGCAGGAGCTGCCTTCC
TTCGCGGTGCCCGCGGGGATCCTCGCCCGGCAGCCCCTCTCCCTCTTCGGGCCACCTGGG
ACGGTACTTCTGGGCCTCTTCTGCGTACATTACTTCCACAGGACATTTGTGTACTCACTG
CTCAATCGAGGGAGGCCTTATCCAGCTATACTCATTCTCAGAGGCACTGCCTTCTGCACT
GGAAATGGAGTCCTTCAAGGCTACTATCTGATTTACTGTGCTGAATACCCTGATGGGTGG
TACACAGACATACGGTTTAGCTTGGGTGTCTTCTTATTTATTTTGGGAATGGGAATAAAC
ATTCATAGTGACTATATATTGCGCCAGCTCAGGAAGCCTGGAGAAATCAGCTACAGGATT
CCACAAGGTGGCTTGTTTACGTATGTTTCTGGAGCCAATTTCCTCGGTGAGATCATTGAA
TGGATCGGCTATGCCCTGGCCACTTGGTCCCTCCCAGCACTTGCATTTGCATTTTTCTCA
CTTTGTTTCCTTGGGCTGCGAGCTTTTCACCACCATAGGTTCTACCTCAAGATGTTTGAG
GACTACCCCAAATCTCGGAAAGCCCTTATTCCATTCATCTTTTAA

Protein Properties

Number of Residues

254

Molecular Weight

28407.035

Theoretical pI

9.395

Pfam Domain Function

Steroid_dh (PF02544 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>3-oxo-5-alpha-steroid 4-dehydrogenase 2
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF

External Links

GenBank ID Protein

338469

UniProtKB/Swiss-Prot ID

P31213

UniProtKB/Swiss-Prot Entry Name

S5A2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

M74047

GeneCard ID