Identification
HMDB Protein ID CDBP00629
Secondary Accession Numbers Not Available
Name Adenosine deaminase
Description Not Available
Synonyms
  1. Adenosine aminohydrolase
Gene Name ADA
Protein Type Enzyme
Biological Properties
General Function Involved in deaminase activity
Specific Function Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
GO Classification
Biological Process
histamine secretion
positive regulation of germinal center formation
hypoxanthine salvage
positive regulation of heart rate
inosine biosynthetic process
positive regulation of smooth muscle contraction
lung alveolus development
positive regulation of T cell differentiation in thymus
negative regulation of adenosine receptor signaling pathway
positive regulation of T cell receptor signaling pathway
negative regulation of circadian sleep/wake cycle, non-REM sleep
purine nucleotide salvage
negative regulation of leukocyte migration
purine ribonucleoside monophosphate biosynthetic process
negative regulation of mature B cell apoptotic process
negative regulation of inflammatory response
regulation of cell-cell adhesion mediated by integrin
negative regulation of mucus secretion
cell adhesion
response to hydrogen peroxide
negative regulation of penile erection
liver development
response to hypoxia
negative regulation of thymocyte apoptotic process
adenosine catabolic process
response to morphine
Peyer's patch development
aging
T cell activation
trophectodermal cell differentiation
placenta development
dATP catabolic process
xanthine biosynthetic process
positive regulation of alpha-beta T cell differentiation
deoxyadenosine catabolic process
positive regulation of B cell proliferation
embryonic digestive tract development
positive regulation of calcium-mediated signaling
germinal center B cell differentiation
Cellular Component
lysosome
neuronal cell body
extracellular space
cytoplasmic membrane-bounded vesicle lumen
dendrite cytoplasm
external side of plasma membrane
cytosol
cell junction
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
deaminase activity
adenosine deaminase activity
Molecular Function
adenosine deaminase activity
purine nucleoside binding
metal ion binding
zinc ion binding
Process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Peripheral membrane protein
  4. Extracellular side
  5. Cell junction
  6. Cytoplasmic vesicle lumen
Pathways
Gene Properties
Chromosome Location 20
Locus 20q13.12
SNPs ADA
Gene Sequence
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA
Protein Properties
Number of Residues 363
Molecular Weight 40764.13
Theoretical pI 5.944
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
GenBank ID Protein 28380
UniProtKB/Swiss-Prot ID P00813
UniProtKB/Swiss-Prot Entry Name ADA_HUMAN
PDB IDs
GenBank Gene ID X02994
GeneCard ID ADA
GenAtlas ID ADA
HGNC ID HGNC:186
References
General References Not Available