Identification |
HMDB Protein ID
| CDBP00509 |
Secondary Accession Numbers
| Not Available |
Name
| Arylacetamide deacetylase |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| AADAC |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in hydrolase activity |
Specific Function
| Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
|
GO Classification
|
Biological Process |
positive regulation of triglyceride catabolic process |
Cellular Component |
endoplasmic reticulum membrane |
integral to membrane |
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
hydrolase activity, acting on ester bonds |
catalytic activity |
hydrolase activity |
carboxylesterase activity |
Molecular Function |
carboxylesterase activity |
deacetylase activity |
retinyl-palmitate esterase activity |
serine hydrolase activity |
triglyceride lipase activity |
Process |
metabolic process |
|
Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
- Single-pass type II membrane protein
- Microsome membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 3 |
Locus
| 3q25.1 |
SNPs
| AADAC |
Gene Sequence
|
>1200 bp
ATGGGAAGAAAATCGCTGTACCTTCTGATTGTGGGGATCCTCATAGCATATTATATTTAT
ACGCCTCTCCCAGATAACGTTGAGGAGCCATGGAGAATGATGTGGATAAACGCACATCTG
AAAACTATACAAAATTTGGCTACATTTGTGGAGCTCCTGGGACTTCACCATTTTATGGAT
TCCTTTAAGGTTGTCGGGAGCTTTGATGAAGTCCCACCAACCTCAGATGAAAATGTCACT
GTGACTGAGACAAAATTCAACAACATTCTTGTTCGGGTATATGTGCCAAAGAGAAAGTCT
GAAGCACTAAGAAGGGGGTTGTTTTACATCCATGGTGGAGGCTGGTGCGTGGGAAGTGCT
GCTCTAAGTGGTTATGACTTGCTGTCAAGATGGACAGCAGACAGACTTGATGCTGTCGTC
GTATCAACCAACTACAGATTAGCACCTAAGTATCATTTCCCAATTCAATTTGAAGATGTA
TATAATGCCTTAAGGTGGTTCTTACGTAAAAAAGTTCTTGCAAAATATGGTGTGAACCCT
GAGAGAATCGGTATTTCTGGAGATAGTGCAGGAGGGAATTTAGCTGCAGCAGTGACTCAA
CAGCTCCTTGATGACCCAGATGTCAAGATCAAACTCAAGATCCAGTCTTTAATTTATCCT
GCCCTTCAGCCTCTTGATGTAGATTTACCGTCATATCAAGAAAATTCAAATTTTCTATTT
CTATCCAAATCACTCATGGTCAGATTCTGGAGTGAATATTTTACCACTGATAGATCACTT
GAAAAAGCCATGCTTTCCAGACAACATGTACCTGTGGAATCAAGTCATCTCTTCAAATTT
ATTAATTGGAGTTCCCTGCTCCCTGAGAGGTTTATAAAAGGACATGTTTATAACAATCCA
AATTATGGCAGTTCTGAGCTGGCTAAAAAATATCCAGGGTTCCTAGATGTGAGGGCAGCC
CCTTTGTTGGCTGATGACAACAAATTACGTGGCTTACCCCTGACCTATGTCATCACCTGT
CAATATGATCTCTTAAGAGATGATGGACTCATGTATGTCACCCGACTTCGCAACACTGGG
GTTCAGGTGACTCATAACCATGTTGAGGATGGATTCCATGGAGCATTTTCATTTCTGGGA
CTTAAAATTAGTCACAGACTTATAAATCAGTATATTGAGTGGCTAAAGGAAAATCTATAG
|
Protein Properties |
Number of Residues
| 399 |
Molecular Weight
| 45733.28 |
Theoretical pI
| 8.692 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Arylacetamide deacetylase
MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFVELLGLHHFMD
SFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKSEALRRGLFYIHGGGWCVGSA
ALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVNP
ERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLF
LSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFINWSSLLPERFIKGHVYNNP
NYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTG
VQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL
|
External Links |
GenBank ID Protein
| 158254688 |
UniProtKB/Swiss-Prot ID
| P22760 |
UniProtKB/Swiss-Prot Entry Name
| AAAD_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK290628 |
GeneCard ID
| AADAC |
GenAtlas ID
| AADAC |
HGNC ID
| HGNC:17 |
References |
General References
| Not Available |