Identification
HMDB Protein ID CDBP00509
Secondary Accession Numbers Not Available
Name Arylacetamide deacetylase
Description Not Available
Synonyms Not Available
Gene Name AADAC
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
GO Classification
Biological Process
positive regulation of triglyceride catabolic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
carboxylesterase activity
Molecular Function
carboxylesterase activity
deacetylase activity
retinyl-palmitate esterase activity
serine hydrolase activity
triglyceride lipase activity
Process
metabolic process
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Single-pass type II membrane protein
  3. Single-pass type II membrane protein
  4. Microsome membrane
Pathways
Gene Properties
Chromosome Location 3
Locus 3q25.1
SNPs AADAC
Gene Sequence
>1200 bp
ATGGGAAGAAAATCGCTGTACCTTCTGATTGTGGGGATCCTCATAGCATATTATATTTAT
ACGCCTCTCCCAGATAACGTTGAGGAGCCATGGAGAATGATGTGGATAAACGCACATCTG
AAAACTATACAAAATTTGGCTACATTTGTGGAGCTCCTGGGACTTCACCATTTTATGGAT
TCCTTTAAGGTTGTCGGGAGCTTTGATGAAGTCCCACCAACCTCAGATGAAAATGTCACT
GTGACTGAGACAAAATTCAACAACATTCTTGTTCGGGTATATGTGCCAAAGAGAAAGTCT
GAAGCACTAAGAAGGGGGTTGTTTTACATCCATGGTGGAGGCTGGTGCGTGGGAAGTGCT
GCTCTAAGTGGTTATGACTTGCTGTCAAGATGGACAGCAGACAGACTTGATGCTGTCGTC
GTATCAACCAACTACAGATTAGCACCTAAGTATCATTTCCCAATTCAATTTGAAGATGTA
TATAATGCCTTAAGGTGGTTCTTACGTAAAAAAGTTCTTGCAAAATATGGTGTGAACCCT
GAGAGAATCGGTATTTCTGGAGATAGTGCAGGAGGGAATTTAGCTGCAGCAGTGACTCAA
CAGCTCCTTGATGACCCAGATGTCAAGATCAAACTCAAGATCCAGTCTTTAATTTATCCT
GCCCTTCAGCCTCTTGATGTAGATTTACCGTCATATCAAGAAAATTCAAATTTTCTATTT
CTATCCAAATCACTCATGGTCAGATTCTGGAGTGAATATTTTACCACTGATAGATCACTT
GAAAAAGCCATGCTTTCCAGACAACATGTACCTGTGGAATCAAGTCATCTCTTCAAATTT
ATTAATTGGAGTTCCCTGCTCCCTGAGAGGTTTATAAAAGGACATGTTTATAACAATCCA
AATTATGGCAGTTCTGAGCTGGCTAAAAAATATCCAGGGTTCCTAGATGTGAGGGCAGCC
CCTTTGTTGGCTGATGACAACAAATTACGTGGCTTACCCCTGACCTATGTCATCACCTGT
CAATATGATCTCTTAAGAGATGATGGACTCATGTATGTCACCCGACTTCGCAACACTGGG
GTTCAGGTGACTCATAACCATGTTGAGGATGGATTCCATGGAGCATTTTCATTTCTGGGA
CTTAAAATTAGTCACAGACTTATAAATCAGTATATTGAGTGGCTAAAGGAAAATCTATAG
Protein Properties
Number of Residues 399
Molecular Weight 45733.28
Theoretical pI 8.692
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Arylacetamide deacetylase
MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFVELLGLHHFMD
SFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKSEALRRGLFYIHGGGWCVGSA
ALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVNP
ERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLF
LSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFINWSSLLPERFIKGHVYNNP
NYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTG
VQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL
GenBank ID Protein 158254688
UniProtKB/Swiss-Prot ID P22760
UniProtKB/Swiss-Prot Entry Name AAAD_HUMAN
PDB IDs Not Available
GenBank Gene ID AK290628
GeneCard ID AADAC
GenAtlas ID AADAC
HGNC ID HGNC:17
References
General References Not Available