487 CDBP00486 Alcohol dehydrogenase [NADP(+)] P14550 AK1A1_HUMAN true false Enzyme Homo_sapiens AKR1A1 325 36572.71 6.793 Involved in oxidoreductase activity Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). 2ALR J04794 AKR1A1 1 1p33-p32 AKR1A1 HGNC:380 true hsa:10327 NP_001189342.1:NM_001202413.1;NP_001189343.1:NM_001202414.1;NP_006057.1:NM_006066.3;NP_697021.1:NM_153326.2 Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. Monomer 2020-06-12T23:06:50Z 2020-06-12T23:06:50Z 0 0 0