Showing Protein Cocaine esterase (CDBP00480)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 6 compounds
Identification
HMDB Protein ID CDBP00480
Secondary Accession Numbers Not Available
Name Cocaine esterase
Description Not Available
Synonyms
  1. CE-2
  2. hCE-2
  3. Carboxylesterase 2
  4. Methylumbelliferyl-acetate deacetylase 2
Gene Name CES2
Protein Type Enzyme
Biological Properties
General Function Lipid transport and metabolism
Specific Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
GO Classification
Biological Process
catabolic process
Cellular Component
endoplasmic reticulum lumen
endoplasmic reticulum
Molecular Function
carboxylesterase activity
retinyl-palmitate esterase activity
methyl indole-3-acetate esterase activity
methyl jasmonate esterase activity
methyl salicylate esterase activity
methylumbelliferyl-acetate deacetylase activity
Cellular Location
  1. Endoplasmic reticulum lumen
Pathways
Gene Properties
Chromosome Location 16
Locus 16q22.1
SNPs CES2
Gene Sequence 
>1680 bp
ATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGGCTTCTGCTGCTT
CTTGTCCGGGGCCAGGGCCAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAG
GTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAAACCTTCCTGGGA
ATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTGAA
TCTTGGAGTGGTGTGAGGGATGGAACCACCCATCCGGCCATGTGTCTACAGGACCTCACC
GCAGTGGAGTCAGAGTTTCTTAGCCAGTTCAACATGACCTTCCCTTCCGACTCCATGTCT
GAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAAGGCTCTAACCTG
CCGGTGATGGTGTGGATCCACGGTGGTGCGCTTGTTTTTGGCATGGCTTCCTTGTATGAT
GGTTCCATGCTGGCTGCCTTGGAGAACGTGGTGGTGGTCATCATCCAGTACCGCCTGGGT
GTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGGGGCTACCTGGAC
CAAGTGGCTGCACTACGCTGGGTCCAGCAGAATATCGCCCACTTTGGAGGCAACCCTGAC
CGTGTCACCATTTTTGGCGAGTCTGCGGGTGGCACGAGTGTGTCTTCGCTTGTTGTGTCC
CCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTGGCCCTCCTGCCC
GGCCTCATTGCCAGCTCAGCTGATGTCATCTCCACGGTGGTGGCCAACCTGTCTGCCTGT
GACCAAGTTGACTCTGAGGCCCTGGTGGGCTGCCTGCGGGGCAAGAGTAAAGAGGAGATT
CTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGGGTCTTCCTGCCC
AGGCACCCCCAGGAGCTGCTGGCCTCTGCCGACTTTCAGCCTGTCCCTAGCATTGTTGGT
GTCAACAACAATGAATTCGGCTGGCTCATCCCCAAGGTCATGAGGATCTATGATACCCAG
AAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTAACGCTGCTGATG
TTGCCTCCTACATTTGGTGACCTGCTGAGGGAGGAGTACATTGGGGACAATGGGGATCCC
CAGACCCTCCAAGCGCAGTTCCAGGAGATGATGGCGGACTCCATGTTTGTGATCCCTGCA
CTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTACGAGTTCCAGCAT
CAGCCCAGCTGGCTCAAGAACATCAGGCCACCGCACATGAAGGCAGACCATGGTGATGAG
CTTCCTTTTGTTTTCAGAAGTTTCTTTGGGGGCAACTACATTAAATTCACTGAGGAAGAG
GAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCCAACTTTGCGAGAAATGGGAACCCC
AATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGCAATACCTGCAGCTG
AACCTACAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAGTTCTGGAAGAAG
GCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCTGAAGAGAGACACACAGAGCTGTAG
Protein Properties
Number of Residues 559
Molecular Weight 68898.39
Theoretical pI 6.489
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Carboxylesterase 2
MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLG
IPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMS
EDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLG
VLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVS
PISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI
LAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQ
KEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPA
LQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEE
EQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKK
ALPQKIQELEEPEERHTEL
GenBank ID Protein 2058318
UniProtKB/Swiss-Prot ID O00748
UniProtKB/Swiss-Prot Entry Name EST2_HUMAN
PDB IDs Not Available
GenBank Gene ID Y09616
GeneCard ID CES2
GenAtlas ID CES2
HGNC ID HGNC:1864
References
General References Not Available