| Identification |
|---|
| HMDB Protein ID
| CDBP00427 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sepiapterin reductase |
| Description
| Not Available |
| Synonyms
|
- SPR
|
| Gene Name
| SPR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| tetrahydrobiopterin biosynthetic process |
| nitric oxide biosynthetic process |
| regulation of nitric-oxide synthase activity |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| oxidoreductase activity, acting on ch-oh group of donors |
| oxidoreductase activity |
| sepiapterin reductase activity |
| Molecular Function |
| NADP binding |
| sepiapterin reductase activity |
| aldo-keto reductase (NADP) activity |
| Process |
| biosynthetic process |
| cellular biosynthetic process |
| heterocycle biosynthetic process |
| pteridine and derivative biosynthetic process |
| oxidation reduction |
| tetrahydrobiopterin biosynthetic process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pterine Biosynthesis |    |  | | Folate biosynthesis | Not Available | | | Dopa-responsive dystonia |    | Not Available | | Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency |    | Not Available | | Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2p14-p12 |
| SNPs
| SPR |
| Gene Sequence
|
>786 bp
ATGGAGGGCGGGCTGGGGCGTGCTGTGTGCTTGCTGACCGGGGCCTCCCGCGGCTTCGGC
CGGACGCTGGCCCCGCTCCTGGCCTCGCTGCTGTCGCCCGGCTCCGTGCTTGTCCTTAGC
GCCCGCAACGACGAGGCACTGCGCCAGCTGGAGGCCGAGCTGGGCGCCGAGCGGTCTGGC
CTGCGCGTGGTGCGGGTGCCCGCCGACCTGGGCGCCGAGGCCGGCTTGCAGCAGCTGCTC
GGCGCCCTGCGCGAGCTCCCCCGGCCCAAGGGGCTGCAGCGACTGCTGCTTATCAACAAC
GCGGGCTCTCTTGGGGATGTGTCCAAAGGCTTCGTGGACCTGAGTGACTCCACTCAAGTG
AACAACTACTGGGCACTGAACTTGACCTCCATGCTCTGCCTGACTTCCAGCGTCCTGAAG
GCCTTCCCGGACAGTCCTGGCCTCAACAGAACCGTGGTTAACATCTCGTCCCTCTGTGCC
CTGCAACCTTTCAAAGGCTGGGCGCTGTACTGTGCAGGAAAGGCTGCTCGTGATATGCTG
TTCCAGGTCCTGGCGCTGGAGGAACCTAATGTGAGGGTGCTGAACTATGCCCCAGGTCCT
CTGGACACAGACATGCAGCAGTTGGCCCGGGAGACCTCCGTGGACCCAGACATGCGAAAA
GGGCTGCAGGAGCTGAAGGCAAAGGGGAAGCTGGTGGATTGCAAGGTGTCAGCCCAGAAA
CTGCTGAGCTTACTGGAAAAGGACGAGTTCAAGTCTGGAGCCCACGTGGACTTCTATGAC
AAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 28048.13 |
| Theoretical pI
| 8.048 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sepiapterin reductase
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
LLSLLEKDEFKSGAHVDFYDK
|
| External Links |
|---|
| GenBank ID Protein
| 338021 |
| UniProtKB/Swiss-Prot ID
| P35270 |
| UniProtKB/Swiss-Prot Entry Name
| SPRE_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M76231 |
| GeneCard ID
| SPR |
| GenAtlas ID
| SPR |
| HGNC ID
| HGNC:11257 |
| References |
|---|
| General References
| Not Available |