Cannabis Compound Database: Showing Protein 6-pyruvoyl tetrahydrobiopterin synthase (CDBP00426)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00426

Secondary Accession Numbers

Not Available

Name

6-pyruvoyl tetrahydrobiopterin synthase

Description

Not Available

Synonyms

PTP synthase
PTPS

Gene Name

PTS

Protein Type

Enzyme

Biological Properties

General Function

Involved in 6-pyruvoyltetrahydropterin synthase activity

Specific Function

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

GO Classification

Biological Process
cellular amino acid metabolic process
nitric oxide metabolic process
tetrahydrobiopterin biosynthetic process
regulation of nitric-oxide synthase activity
central nervous system development
Cellular Component
cytosol
mitochondrion
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
lyase activity
carbon-oxygen lyase activity
carbon-oxygen lyase activity, acting on phosphates
6-pyruvoyltetrahydropterin synthase activity
Molecular Function
metal ion binding
6-pyruvoyltetrahydropterin synthase activity
Process
tetrahydrobiopterin biosynthetic process
metabolic process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
pteridine and derivative biosynthetic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
tetrahydrobiopterin biosynthesis	Not Available	Not Available
Folate biosynthesis	Not Available
Pterine Biosynthesis
Dopa-responsive dystonia		Not Available
Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency		Not Available

Gene Properties

Chromosome Location

Locus

11q22.3

SNPs

PTS

Gene Sequence

>438 bp
ATGAGCACGGAAGGTGGTGGCCGTCGCTGCCAGGCACAAGTGTCCCGCCGCATCTCCTTC
AGCGCGAGCCACCGATTGTACAGTAAATTTCTAAGTGATGAAGAAAACTTGAAACTGTTT
GGGAAATGCAACAATCCAAATGGCCATGGGCACAATTATAAAGTTGTGGTGACAGTACAT
GGAGAGATTGACCCTGCTACGGGAATGGTTATGAATCTGGCTGATCTCAAAAAATATATG
GAGGAGGCGATTATGCAGCCCCTTGATCATAAGAATCTGGATATGGATGTGCCATACTTT
GCAGATGTGGTGAGCACGACTGAAAATGTAGCTGTTTATATCTGGGACAACCTCCAGAAA
GTTCTTCCTGTAGGAGTTCTTTATAAAGTAAAAGTATACGAAACTGACAATAATATTGTG
GTTTATAAAGGAGAATAG

Protein Properties

Number of Residues

145

Molecular Weight

16385.63

Theoretical pI

6.68

Pfam Domain Function

PTPS (PF01242 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>6-pyruvoyl tetrahydrobiopterin synthase
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVH
GEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQK
VLPVGVLYKVKVYETDNNIVVYKGE

External Links

GenBank ID Protein

7768658

UniProtKB/Swiss-Prot ID

Q03393

UniProtKB/Swiss-Prot Entry Name

PTPS_HUMAN

PDB IDs