| Identification |
|---|
| HMDB Protein ID
| CDBP00368 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glucose-6-phosphatase |
| Description
| Not Available |
| Synonyms
|
- G-6-Pase
- G6Pase
- G6Pase-alpha
- Glucose-6-phosphatase alpha
|
| Gene Name
| G6PC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
|
| GO Classification
|
| Biological Process |
| glycogen metabolic process |
| gluconeogenesis |
| steroid metabolic process |
| glucose homeostasis |
| cholesterol homeostasis |
| multicellular organism growth |
| glycogen catabolic process |
| regulation of gene expression |
| triglyceride metabolic process |
| transmembrane transport |
| small molecule metabolic process |
| glucose transport |
| glucose 6-phosphate metabolic process |
| glucose-6-phosphate transport |
| urate metabolic process |
| Cellular Component |
| integral to endoplasmic reticulum membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| Molecular Function |
| phosphate ion binding |
| phosphotransferase activity, alcohol group as acceptor |
| glucose-6-phosphatase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | PI3K-Akt signaling pathway | Not Available |  | | Insulin signaling pathway | Not Available |  | | Adipocytokine signaling pathway | Not Available |  | | Carbohydrate digestion and absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q21 |
| SNPs
| G6PC |
| Gene Sequence
|
>1074 bp
ATGGAGGAAGGAATGAATGTTCTCCATGACTTTGGGATCCAGTCAACACATTACCTCCAG
GTGAATTACCAAGACTCCCAGGACTGGTTCATCTTGGTGTCCGTGATCGCAGACCTCAGG
AATGCCTTCTACGTCCTCTTCCCCATCTGGTTCCATCTTCAGGAAGCTGTGGGCATTAAA
CTCCTTTGGGTAGCTGTGATTGGAGACTGGCTCAACCTCGTCTTTAAGTGGATTCTCTTT
GGACAGCGTCCATACTGGTGGGTTTTGGATACTGACTACTACAGCAACACTTCCGTGCCC
CTGATAAAGCAGTTCCCTGTAACCTGTGAGACTGGACCAGGGAGCCCCTCTGGCCATGCC
ATGGGCACAGCAGGTGTATACTACGTGATGGTCACATCTACTCTTTCCATCTTTCAGGGA
AAGATAAAGCCGACCTACAGATTTCGGTGCTTGAATGTCATTTTGTGGTTGGGATTCTGG
GCTGTGCAGCTGAATGTCTGTCTGTCACGAATCTACCTTGCTGCTCATTTTCCTCATCAA
GTTGTTGCTGGAGTCCTGTCAGGCATTGCTGTTGCAGAAACTTTCAGCCACATCCACAGC
ATCTATAATGCCAGCCTCAAGAAATATTTTCTCATTACCTTCTTCCTGTTCAGCTTCGCC
ATCGGATTTTATCTGCTGCTCAAGGGACTGGGTGTAGACCTCCTGTGGACTCTGGAGAAA
GCCCAGAGGTGGTGCGAGCAGCCAGAATGGGTCCACATTGACACCACACCCTTTGCCAGC
CTCCTCAAGAACCTGGGCACGCTCTTTGGCCTGGGGCTGGCTCTCAACTCCAGCATGTAC
AGGGAGAGCTGCAAGGGGAAACTCAGCAAGTGGCTCCCATTCCGCCTCAGCTCTATTGTA
GCCTCCCTCGTCCTCCTGCACGTCTTTGACTCCTTGAAACCCCCATCCCAAGTCGAGCTG
GTCTTCTACGTCTTGTCCTTCTGCAAGAGTGCGGTAGTGCCCCTGGCATCCGTCAGTGTC
ATCCCCTACTGCCTCGCCCAGGTCCTGGGCCAGCCGCACAAGAAGTCGTTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 357 |
| Molecular Weight
| 40483.21 |
| Theoretical pI
| 8.476 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glucose-6-phosphatase
MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK
LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA
MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ
VVAGVLSGIAVAETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK
AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV
ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL
|
| External Links |
|---|
| GenBank ID Protein
| 189054175 |
| UniProtKB/Swiss-Prot ID
| P35575 |
| UniProtKB/Swiss-Prot Entry Name
| G6PC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK313982 |
| GeneCard ID
| G6PC |
| GenAtlas ID
| G6PC |
| HGNC ID
| HGNC:4056 |
| References |
|---|
| General References
| Not Available |