| Identification |
|---|
| HMDB Protein ID
| CDBP00366 |
| Secondary Accession Numbers
| Not Available |
| Name
| Trehalase |
| Description
| Not Available |
| Synonyms
|
- Alpha,alpha-trehalase
- Alpha,alpha-trehalose glucohydrolase
|
| Gene Name
| TREH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| trehalose catabolic process |
| polysaccharide digestion |
| Cellular Component |
| anchored to plasma membrane |
| Function |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| trehalase activity |
| alpha,alpha-trehalase activity |
| Molecular Function |
| alpha,alpha-trehalase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| oligosaccharide metabolic process |
| disaccharide metabolic process |
| trehalose metabolic process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Trehalose Degradation |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q23.3 |
| SNPs
| TREH |
| Gene Sequence
|
>1752 bp
ATGCCAGGGAGGACCTGGGAGCTGTGCCTGCTACTGCTGCTGGGGCTGGGACTGGGGTCC
CAGGAGGCCCTACCCCCACCCTGTGAGAGTGAGATTTACTGCCACGGGGAGCTCCTAAAC
CAAGTTCAAATGGCCAAGCTCTACCAGGATGACAAGCAGTTTGTGGACATGCCACTGTCT
ATAGCTCCAGAACAAGTCCTGCAGACCTTCACTGAGCTGTCCAGGGACCACAATCACAGC
ATCCCCAGGGAGCAGCTGCAGGCGTTTGTCCACGAACACTTCCAGGCCAAGGGGCAGGAG
CTGCAGCCCTGGACCCCTGCAGACTGGAAAGACAGCCCCCAGTTCCTGCAGAAGATTTCA
GATGCCAAACTGCGTGCCTGGGCAGGGCAGCTGCATCAGCTCTGGAAGAAGCTGGGGAAG
AAGATGAAGCCAGAGGTTCTCAGCCACCCTGAGCGGTTCTCTCTCATATACTCAGAACAT
CCTTTCATTGTGCCTGGCGGTCGCTTTGTTGAGTTCTACTACTGGGACTCCTACTGGGTC
ATGGAGGGTCTGCTCCTCTCAGAGATGGCTGAGACGGTGAAGGGCATGCTGCAGAACTTC
TTGGACCTGGTGAAAACCTATGGGCATGTCCCCAATGGTGGGCGCGTGTACTACTTGCAG
CGGAGCCAGCCCCCACTCTTGACCCTCATGATGGATTGCTACTTGACTCACACCAATGAC
ACCGCCTTTCTACAGGAAAACATTGAAACACTAGCCTTGGAATTGGACTTTTGGACCAAG
AACAGGACTGTCTCTGTGAGCTTGGAGGGAAAGAACTACCTCCTGAATCGCTATTATGTC
CCTTATGGGGGACCCAGGCCTGAGTCCTACAGCAAAGATGTGGAGTTGGCTGACACCTTG
CCAGAAGGAGACCGGGAGGCTCTGTGGGCTGAGCTCAAGGCTGGGGCTGAGTCTGGCTGG
GACTTCTCTTCACGCTGGCTCATTGGAGGCCCAAACCCCAACTCGCTTAGCGGCATCCGA
ACAAGCAAACTGGTGCCTGTTGACCTGAATGCCTTCCTATGCCAAGCAGAGGAGCTGATG
AGCAACTTCTATTCCAGGCTGGGGAACGACTCCCAGGCCACGAAGTACAGAATCCTGCGG
TCGCAGCGCTTGGCCGCCCTGAACACAGTCCTGTGGGATGAGCAGACCGGAGCCTGGTTC
GATTACGACCTTGAGAAGAAGAAGAAAAACCGGGAGTTTTACCCATCCAACCTCACTCCA
CTCTGGGCCGGGTGTTTCTCTGACCCTGGCGTGGCGGACAAGGCTCTGAAATACCTGGAG
GACAACCGGATCCTGACTTACCAGTATGGGATCCCGACCTCTCTCCAGAAGACAGGCCAG
CAGTGGGATTTCCCCAATGCCTGGGCCCCCCTGCAGGACTTGGTCATCAGAGGCCTGGCC
AAGGCACCTTTACGTCGGGCCCAGGAAGTGGCTTTCCAGCTGGCTCAGAATTGGATCCGA
ACCAATTTTGATGTCTACTCGCAGAAGTCAGCCATGTATGAGAAGTATGACGTCAGCAAC
GGTGGACAGCCCGGTGGGGGAGGAGAATATGAAGTTCAGGAGGGATTTGGCTGGGACGAA
GGTGTGGTCCTGATGCTGCTGGACCGCTATGGTGACCGGCTGACCTCAGGGGCCAAGCTG
GCTTTCCTGGAGCCCCACTGCCTGGCGGCCACCCTTCTGCCCAGCCTCCTGCTCAGCCTC
CTGCCATGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 583 |
| Molecular Weight
| 66567.26 |
| Theoretical pI
| 5.678 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Trehalase
MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLS
IAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKIS
DAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWV
MEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTND
TAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTL
PEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLSGIRTSKLVPVDLNAFLCQAEELM
SNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNLTP
LWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLA
KAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWTN
GVVLMLLDRYGDRLTSGAKLAFLEPHCLAATLLPSLLLSLLPW
|
| External Links |
|---|
| GenBank ID Protein
| 2789461 |
| UniProtKB/Swiss-Prot ID
| O43280 |
| UniProtKB/Swiss-Prot Entry Name
| TREA_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB000824 |
| GeneCard ID
| TREH |
| GenAtlas ID
| TREH |
| HGNC ID
| HGNC:12266 |
| References |
|---|
| General References
| Not Available |