Identification |
HMDB Protein ID
| CDBP00356 |
Secondary Accession Numbers
| Not Available |
Name
| Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A |
Description
| Not Available |
Synonyms
|
- Inositol polyphosphate 5-phosphatase J
|
Gene Name
| INPP5J |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in inositol or phosphatidylinositol phosphatase activity |
Specific Function
| Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).
|
GO Classification
|
Biological Process |
small molecule metabolic process |
phosphatidylinositol biosynthetic process |
negative regulation of microtubule polymerization |
phosphatidylinositol phosphorylation |
negative regulation of neuron projection development |
negative regulation of peptidyl-serine phosphorylation |
Cellular Component |
cytosol |
growth cone |
ruffle |
plasma membrane |
dendritic shaft |
Function |
phosphatase activity |
inositol or phosphatidylinositol phosphatase activity |
hydrolase activity, acting on ester bonds |
catalytic activity |
hydrolase activity |
phosphoric ester hydrolase activity |
Molecular Function |
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity |
inositol-1,4,5-trisphosphate 5-phosphatase activity |
inositol-polyphosphate 5-phosphatase activity |
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Phosphatidylinositol signaling system | Not Available | | Inositol Phosphate Metabolism | | | Inositol Metabolism | | |
|
Gene Properties |
Chromosome Location
| 22 |
Locus
| 22q12.2 |
SNPs
| INPP5J |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 1006 |
Molecular Weight
| 70238.575 |
Theoretical pI
| 8.673 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRLALA
PVGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASA
GPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTL
AASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDA
PAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRP
PQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSP
CVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSD
PGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFT
DQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNK
GGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFW
FGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKF
DVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSD
HKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGF
RHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQIS
LPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALR
PSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGL
LPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP
|
External Links |
GenBank ID Protein
| 50726960 |
UniProtKB/Swiss-Prot ID
| Q15735 |
UniProtKB/Swiss-Prot Entry Name
| PI5PA_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| INPP5J |
GenAtlas ID
| INPP5J |
HGNC ID
| HGNC:8956 |
References |
General References
| Not Available |