| Identification |
|---|
| HMDB Protein ID
| CDBP00354 |
| Secondary Accession Numbers
| Not Available |
| Name
| Type I inositol 1,4,5-trisphosphate 5-phosphatase |
| Description
| Not Available |
| Synonyms
|
- 5PTase
|
| Gene Name
| INPP5A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in inositol or phosphatidylinositol phosphatase activity |
| Specific Function
| Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
|
| GO Classification
|
| Biological Process |
| cell communication |
| phosphatidylinositol phosphorylation |
| Cellular Component |
| membrane |
| Function |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| inositol or phosphatidylinositol phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| Molecular Function |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity |
| inositol-1,4,5-trisphosphate 5-phosphatase activity |
| inositol-polyphosphate 5-phosphatase activity |
|
| Cellular Location
|
- Lipid-anchor
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phosphatidylinositol signaling system | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q26.3 |
| SNPs
| INPP5A |
| Gene Sequence
|
>1239 bp
ATGGCGGGGAAGGCGGCCGCCCCGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGC
TCGCTCTTCGACGACCCAGAAAACCTGCAGAAGAACTGGCTTCGGGAATTTTACCAGGTC
GTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGGGAAGAAC
TACGAGGCCTCCATGTCCCACGTGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCG
ATGAAAGAATATAACAGGGCTCGAGTCTACCTGGATGAAAACTACAAATCCCAGGAGCAC
TTCACGGCACTAGGAAGCTTTTATTTTCTTCATGAGTCCTTAAAAAACATCTACCAGTTT
GACTTTAAAGCTAAGAAGTATAGAAAGGTCGCTGGCAAAGAGATCTACTCGGATACCTTA
GAGAGCACGCCCATGCTGGAGAAGGAGAAGTTTCCGCAGGACTACTTCCCCGAGTGCAAA
TGGTCAAGAAAAGGCTTCATCCGGACGAGGTGGTGCATTGCAGACTGTGCCTTTGACTTG
GTGAATATCCATCTTTTCCATGATGCTTCCAATCTGGTCGCCTGGGAAACAAGCCCTTCC
GTGTACTCGGGAATCCGGCACAAGGCACTGGGCTACGTGCTGGACAGAATCATTGATCAG
CGATTCGAGAAGGTTTCCTACTTTGTATTTGGTGATTTCAACTTCCGGCTGGATTCCAAG
TCCGTCGTGGAGACGCTCTGCACAAAAGCCACCATGCAGACGGTCCGGGCCGCCGACACC
AATGAAGTGGTGAAGCTCATATTTCGTGAGTCGGACAACGACCGGAAGGTTATGCTCCAG
TTAGAAAAGAAACTCTTCGACTACTTCAACCAGGAGGTTTTCCGAGACAACAACGGCACC
GCGCTCTTGGAGTTTGACAAGGAGTTGTCTGTCTTTAAGGACAGACTGTATGAACTGGAC
ATCTCGTTCCCTCCCAGCTACCCGTACAGTGAGGACGCCCGCCAGGGTGAGCAGTACATG
AACACCCGGTGCCCAGCCTGGTGTGACCGCATCCTCATGTCCCCGTCTGCCAAGGAGCTG
GTGCTGCGGTCGGAGAGCGAGGAGAAGGTTGTCACCTATGACCACATTGGGCCCAACGTC
TGCATGGGAGACCACAAGCCCGTGTTCCTGGCCTTCCGAATCATGCCCGGGGCAGGTAAA
CCTCATGCCCATGTGCACAAGTGTTGTGTCGTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 47819.155 |
| Theoretical pI
| 7.04 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Type I inositol-1,4,5-trisphosphate 5-phosphatase
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN
YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF
DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL
VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK
SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT
ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL
VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
|
| External Links |
|---|
| GenBank ID Protein
| 57209040 |
| UniProtKB/Swiss-Prot ID
| Q14642 |
| UniProtKB/Swiss-Prot Entry Name
| I5P1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL356603 |
| GeneCard ID
| INPP5A |
| GenAtlas ID
| INPP5A |
| HGNC ID
| HGNC:6076 |
| References |
|---|
| General References
| Not Available |