Cannabis Compound Database: Showing Protein N-acylglucosamine 2-epimerase (CDBP00328)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP00328

Secondary Accession Numbers

Not Available

Name

N-acylglucosamine 2-epimerase

Description

Not Available

Synonyms

AGE
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
Renin-binding protein
RnBP

Gene Name

RENBP

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

GO Classification

Biological Process
N-acetylneuraminate catabolic process
mannose metabolic process
regulation of blood pressure
N-acetylglucosamine metabolic process
Function
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
catalytic activity
mannose-6-phosphate isomerase activity
isomerase activity
Molecular Function
endopeptidase inhibitor activity
mannose-6-phosphate isomerase activity
ATP binding
N-acylglucosamine 2-epimerase activity
Process
metabolic process
mannose metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
N-acetylneuraminate degradation	Not Available	Not Available
Amino sugar and nucleotide sugar metabolism	Not Available
Amino Sugar Metabolism
Sialuria or French Type Sialuria		Not Available
Salla Disease/Infantile Sialic Acid Storage Disease		Not Available

Gene Properties

Chromosome Location

Locus

Xq28

SNPs

RENBP

Gene Sequence

>1284 bp
ATGAGCAAGGGTCTCCCAGCGCGACAGGACATGGAGAAAGAGCGAGAGACTCTGCAGGCC
TGGAAGGAGCGCGTGGGGCAGGAGCTGGACCGCGTGGTGGCTTTCTGGATGGAGCACTCC
CACGACCAGGAGCACGGGGGCTTCTTCACGTGCCTTGGCCGCGAGGGGCGGGTGTATGAT
GACCTCAAGTATGTGTGGCTGCAGGGGAGGCAGGTATGGATGTATTGTCGCCTGTACCGC
ACTTTCGAGCGCTTCCGCCATGCTCAGCTTCTGGACGCAGCAAAAGCAGGTGGTGAGTTC
TTGCTGCGGTATGCCCGGGTGGCACCTCCTGGCAAGAAGTGTGCCTTTGTGCTGACTCGG
GACGGCCGCCCGGTCAAGGTGCAGCGAACCATCTTCAGTGAGTGTTTCTACACCATGGCC
ATGAACGAGCTGTGGAGAGCCACAGGGGAAGTGCGGTACCAGACGGAAGCGGTGGAGATG
ATGGATCAGATCGTCCACTGGGTGCAGGAGGACGCGTCGGGACTGGGCCGGCCCCAGCTC
CAGGGGGCCCCGGCTGCGGAGCCCATGGCGGTGCCCATGATGCTACTGAACCTGGTGGAG
CAGCTCGGGGAGGCAGATGAGGAGCTGGCGGGCAAATACGCAGAGCTGGGGGACTGGTGC
GCCCGGAGGATTCTGCAGCACGTGCAGAGGGATGGACAAGCTGTGCTGGAGAATGTGTCA
GAGGGTGGCAAGGAACTTCCTGGCTGCCTGGGGAGACAGCAGAACCCAGGCCACACGCTG
GAAGCCGGCTGGTTTCTGCTCCGTCATTGCATTCGGAAAGGCGACCCCGAACTTCGAGCC
CACGTGATTGACAAGTTCCTATTGTTGCCCTTCCACTCCGGATGGGACCCTGACCACGGA
GGCCTCTTTTACTTCCAGGATGCTGATAACTTCTGCCCCACCCAGCTGGAGTGGGCCATG
AAGCTCTGGTGGCCACACAGTGAAGCCATGATTGCCTTCCTCATGGGTTACAGTGACAGT
GGGGACCCTGTGCTGCTGCGCCTCTTCTACCAAGTGGCTGAGTACACCTTCCGCCAGTTT
CGCGATCCCGAGTACGGGGAATGGTTTGGCTACCTGAGCCGAGAGGGCAAGGTGGCCCTC
TCCATCAAGGGAGGTCCTTTCAAAGGCTGCTTCCACGTGCCGCGGTGCCTAGCCATGTGC
GAGGAGATGCTGGGCGCCCTGCTGAGCCGCCCCGCCCCCGCCCCCTCCCCCGCCCCCACC
CCCGCCTGCCGAGGCGCGGAATAA

Protein Properties

Number of Residues

427

Molecular Weight

48830.6

Theoretical pI

6.365

Pfam Domain Function

GlcNAc_2-epim (PF07221 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>N-acylglucosamine 2-epimerase
MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYD
DLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTR
DGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQL
QGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVS
EGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHG
GLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQF
RDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPT
PACRGAE

External Links

GenBank ID Protein

213417820

UniProtKB/Swiss-Prot ID

P51606

UniProtKB/Swiss-Prot Entry Name

RENBP_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_002910.5

GeneCard ID