| Identification |
|---|
| HMDB Protein ID
| CDBP00327 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sialic acid synthase |
| Description
| Not Available |
| Synonyms
|
- N-acetylneuraminate synthase
- N-acetylneuraminate-9-phosphate synthase
- N-acetylneuraminic acid phosphate synthase
- N-acetylneuraminic acid synthase
|
| Gene Name
| NANS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
|
| GO Classification
|
| Biological Process |
| lipopolysaccharide biosynthetic process |
| Cellular Component |
| cytosol |
| cytoplasm |
| Function |
| catalytic activity |
| Molecular Function |
| N-acetylneuraminate synthase activity |
| N-acylneuraminate-9-phosphate synthase activity |
| N-acylneuraminate cytidylyltransferase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| carbohydrate biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amino sugar and nucleotide sugar metabolism | Not Available |  | | Amino Sugar Metabolism |    | | | Sialuria or French Type Sialuria |    | Not Available | | Salla Disease/Infantile Sialic Acid Storage Disease |    | Not Available | | Tay-Sachs Disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9p24.1-p23 |
| SNPs
| NANS |
| Gene Sequence
|
>1080 bp
ATGCCGCTGGAGCTGGAGCTGTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTC
ATCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAAGCGCATGATC
CGCATGGCCAAGGAGTGTGGGGCTGATTGTGCCAAGTTCCAGAAGAGTGAGCTAGAATTC
AAGTTTAATCGGAAAGCCTTGGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACG
TACGGGGAGCACAAACGACATCTGGAGTTCAGCCATGACCAGTACAGGGAGCTGCAGAGG
TACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGATGGCAGTTGAA
TTCCTGCATGAACTGAATGTTCCATTTTTCAAAGTTGGATCTGGAGACACTAATAATTTT
CCTTATCTGGAAAAGACAGCCAAAAAAGGTCGCCCAATGGTGATCTCCAGTGGGATGCAG
TCAATGGACACCATGAAGCAAGTTTATCAGATCGTGAAGCCCCTCAACCCCAACTTCTGC
TTCTTGCAGTGTACCAGCGCATACCCGCTCCAGCCTGAGGACGTCAACCTGCGGGTCATC
TCGGAATATCAGAAGCTCTTTCCTGACATTCCCATAGGGTATTCTGGGCATGAAACAGGC
ATAGCGATATCTGTGGCCGCAGTGGCTCTGGGGGCCAAGGTGTTGGAACGTCACATAACT
TTGGACAAGACCTGGAAGGGGAGTGACCACTCGGCCTCGCTGGAGCCTGGAGAACTGGCC
GAGCTGGTGCGGTCAGTGCGTCTTGTGGAGCGTGCCCTGGGCTCCCCAACCAAGCAGCTG
CTGCCCTGTGAGATGGCCTGCAATGAGAAGCTGGGCAAGTCTGTGGTGGCCAAAGTGAAA
ATTCCGGAAGGCACCATTCTAACAATGGACATGCTCACCGTGAAGGTGGGTGAGCCCAAA
GCCTATCCTCCTGAAGACATCTTTAATCTAGTGGGCAAGAAGGTCCTGGTCACTGTTGAA
GAGGATGACACCATCATGGAAGAATTGGTAGATAATCATGGCAAAAAAATCAAGTCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 359 |
| Molecular Weight
| 40307.26 |
| Theoretical pI
| 6.744 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sialic acid synthase
MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEF
KFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVE
FLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFC
FLQCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHIT
LDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVK
IPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELVDNHGKKIKS
|
| External Links |
|---|
| GenBank ID Protein
| 8453156 |
| UniProtKB/Swiss-Prot ID
| Q9NR45 |
| UniProtKB/Swiss-Prot Entry Name
| SIAS_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF257466 |
| GeneCard ID
| NANS |
| GenAtlas ID
| NANS |
| HGNC ID
| HGNC:19237 |
| References |
|---|
| General References
| Not Available |