| Identification |
|---|
| HMDB Protein ID
| CDBP00300 |
| Secondary Accession Numbers
| Not Available |
| Name
| L-xylulose reductase |
| Description
| Not Available |
| Synonyms
|
- Carbonyl reductase II
- Dicarbonyl/L-xylulose reductase
- Kidney dicarbonyl reductase
- Sperm surface protein P34H
- XR
- kiDCR
|
| Gene Name
| DCXR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
|
| GO Classification
|
| Biological Process |
| D-xylose metabolic process |
| NADP metabolic process |
| xylulose metabolic process |
| glucose metabolic process |
| protein homotetramerization |
| Cellular Component |
| brush border |
| microvillus |
| membrane |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| L-xylulose reductase (NADP+) activity |
| oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor |
| nucleotide binding |
| Process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Peripheral membrane protein
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pentose and glucuronate interconversions | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q25.3 |
| SNPs
| DCXR |
| Gene Sequence
|
>735 bp
ATGGAGCTGTTCCTCGCGGGCCGCCGGGTGCTGGTCACCGGGGCAGGCAAAGGTATAGGG
CGCGGCACGGTCCAGGCGCTGCACGCGACGGGCGCGCGGGTGGTGGCTGTGAGCCGGACT
CAGGCGGATCTTGACAGCCTTGTCCGCGAGTGCCCGGGGATAGAACCCGTGTGCGTGGAC
CTGGGTGACTGGGAGGCCACCGAGCGGGCGCTGGGCAGCGTGGGCCCCGTGGACCTGCTG
GTGAACAACGCCGCTGTCGCCCTGCTGCAGCCCTTCCTGGAGGTCACCAAGGAGGCCTTT
GACAGATCCTTTGAGGTGAACCTGCGTGCGGTCATCCAGGTGTCGCAGATTGTGGCCAGG
GGCTTAATAGCCCGGGGAGTCCCAGGGGCCATCGTGAATGTCTCCAGCCAGTGCTCCCAG
CGGGCAGTAACTAACCATAGCGTCTACTGCTCCACCAAGGGTGCCCTGGACATGCTGACC
AAGGTGATGGCCCTAGAGCTCGGGCCCCACAAGATCCGAGTGAATGCAGTAAACCCCACA
GTGGTGATGACGTCCATGGGCCAGGCCACCTGGAGTGACCCCCACAAGGCCAAGACTATG
CTGAACCGAATCCCACTTGGCAAGTTTGCTGAGGTAGAGCACGTGGTGAACGCCATCCTC
TTTCTGCTGAGTGACCGAAGTGGCATGACCACGGGTTCCACTTTGCCGGTGGAAGGGGGC
TTCTGGGCCTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 25742.665 |
| Theoretical pI
| 8.109 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-xylulose reductase
MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD
LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR
GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT
VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG
FWAC
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q7Z4W1 |
| UniProtKB/Swiss-Prot Entry Name
| DCXR_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB013846 |
| GeneCard ID
| DCXR |
| GenAtlas ID
| DCXR |
| HGNC ID
| HGNC:18985 |
| References |
|---|
| General References
| Not Available |